Abdul Arif Khan1, Abdulwahab A Abuderman2, Mohd Tashfeen Ashraf3, Zakir Khan4. 1. Department of Pharmaceutics, College of Pharmacy, PO Box 2457, King Saud University, Riyadh, 11451, Saudi Arabia. 2. Department of Basic Medical Sciences, College of Medicine, Prince Sattam Bin Abdulaziz University, Al Kharj, Saudi Arabia. 3. School of Biotechnology, Gautam Buddha University, Gautam Budh Nagar, Greater Noida, Uttar Pradesh, 201312, India. 4. Department of Biomedical Sciences, Cedars-Sinai Medical Center, 8700 Baverly Blvd., Los Angeles, CA 90048, USA.
Abstract
Aim: HPV is an important cause of cervical cancer, but Chlamydia trachomatis (CT) is suspiciously involved in this disease ranging from direct to its involvement as a cofactor with HPV. We performed this study to understand the interaction of HPV and C. trachomatis with humans and its contribution to cervical cancer. Materials & methods: Host-pathogen and pathogen-pathogen protein-protein interaction maps of HPV/CT/human were prepared and compared to analyze interactions during single/coinfection of C. trachomatis and HPV. The interacting human proteins were detected by their involvement in cervical cancer. Results: C. trachomatis may interact with several cancer associated proteins while HPV and C. trachomatis largely interact with different human proteins, suggesting different pathogenesis. Conclusion: C. trachomatis coinfection with HPV may modulate cervical cancer development.
Aim: HPV is an important cause of cervical cancer, but Chlamydia trachomatis (CT) is suspiciously involved in this disease ranging from direct to its involvement as a cofactor with HPV. We performed this study to understand the interaction of HPV and C. trachomatis with humans and its contribution to cervical cancer. Materials & methods: Host-pathogen and pathogen-pathogen protein-protein interaction maps of HPV/CT/human were prepared and compared to analyze interactions during single/coinfection of C. trachomatis and HPV. The interacting human proteins were detected by their involvement in cervical cancer. Results:C. trachomatis may interact with several cancer associated proteins while HPV and C. trachomatis largely interact with different human proteins, suggesting different pathogenesis. Conclusion:C. trachomatiscoinfection with HPV may modulate cervical cancer development.
Entities:
Keywords:
cervical cancer; domain interactions; gold standard PPI; homology; protein interactions
Authors: Abdul Arif Khan; Mohd Tashfeen Ashraf; Fahad M Aldakheel; Ayca Sayi Yazgan; Rana Zaidi Journal: Am J Transl Res Date: 2022-01-15 Impact factor: 4.060
Authors: Gabriel Viliod Vieira; Fernanda Somera Dos Santos; Ana Paula Lepique; Carol Kobori da Fonseca; Lara Maria Alencar Ramos Innocentini; Paulo Henrique Braz-Silva; Silvana Maria Quintana; Katiuchia Uzzun Sales Journal: Cancers (Basel) Date: 2022-06-21 Impact factor: 6.575