Literature DB >> 3247281

Effects of dithiothreitol and ascorbate on the penetration of diclofenac across excised rat dorsal skin.

T Nishihata1, J H Rytting, K Takahashi, K Sakai.   

Abstract

The penetration of diclofenac through excised rat dorsal skin was found to be poor. Treatment of the skin with a reductant such as dithiothreitol or ascorbate increased the permeability of the skin to diclofenac, along with an increase in the protein thiol content of the stripped skin surface tissue. An increase in protein thiol content may increase the hydration capability of the stratum corneum.

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Year:  1988        PMID： 3247281     DOI： 10.1023/a:1015920230676

Source DB:  PubMed          Journal:  Pharm Res        ISSN： 0724-8741            Impact factor:   4.200


  15 in total

1.  The cornified envelope of terminally differentiated human epidermal keratinocytes consists of cross-linked protein.

Authors:  R H Rice; H Green
Journal:  Cell       Date:  1977-06       Impact factor: 41.582

2.  Rat percutaneous transport of diclofenac and influence of hydrogenated soya phospholipids.

Authors:  T Nishihata; K Kotera; Y Nakano; M Yamazaki
Journal:  Chem Pharm Bull (Tokyo)       Date:  1987-09       Impact factor: 1.645

3.  Influence of diethyl maleate-induced loss of thiols on cefmetazole uptake into isolated epithelial cells and on cefmetazole absorption from ileal loop of rats.

Authors:  T Nishihata; T Suzuka; A Furuya; M Yamazaki; A Kamada
Journal:  Chem Pharm Bull (Tokyo)       Date:  1987-07       Impact factor: 1.645

4.  Variation in physical dimensions and chemical composition of human stratum corneum.

Authors:  R L Anderson; J M Cassidy
Journal:  J Invest Dermatol       Date:  1973-07       Impact factor: 8.551

5.  The membrane protein of horny cells.

Authors:  A G Matoltsy; M N Matoltsy
Journal:  J Invest Dermatol       Date:  1966-01       Impact factor: 8.551

6.  Enhanced percutaneous penetration with 1-dodecylazacycloheptan-2-one.

Authors:  R B Stoughton
Journal:  Arch Dermatol       Date:  1982-07

7.  Menadione-induced cytotoxicity is associated with protein thiol oxidation and alteration in intracellular Ca2+ homeostasis.

Authors:  D Di Monte; G Bellomo; H Thor; P Nicotera; S Orrenius
Journal:  Arch Biochem Biophys       Date:  1984-12       Impact factor: 4.013

8.  Sequential alterations in globin gene chromatin structure during erythroleukemia cell differentiation.

Authors:  J Yu; R D Smith
Journal:  J Biol Chem       Date:  1985-03-10       Impact factor: 5.157

9.  Keratin filaments of cultured human epidermal cells. Formation of intermolecular disulfide bonds during terminal differentiation.

Authors:  T T Sun; H Green
Journal:  J Biol Chem       Date:  1978-03-25       Impact factor: 5.157

10.  Absorption through human skin of ibuprofen and flurbiprofen; effect of dose variation, deposited drug films, occlusion and the penetration enhancer N-methyl-2-pyrrolidone.

Authors:  S A Akhter; B W Barry
Journal:  J Pharm Pharmacol       Date:  1985-01       Impact factor: 3.765
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  1 in total

1.  Passive and iontophoretic transport enhancement of insulin through porcine epidermis by depilatories: permeability and fourier transform infrared spectroscopy studies.

Authors:  Sumeet K Rastogi; Jagdish Singh
Journal:  AAPS PharmSciTech       Date:  2003       Impact factor: 3.246
  1 in total

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