BACKGROUND: COVID-19 is a pandemic disease caused by a novel coronavirus, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Predictors for severe COVID-19 infection have not been well defined. Determination of risk factors for severe infection would enable identifying patients who may benefit from aggressive supportive care and early intervention. METHODS: We conducted a retrospective observational study of 197 patients with confirmed COVID-19 admitted to a tertiary academic medical center. RESULTS: Of 197 hospitalized patients, the mean (SD) age of the cohort was 60.6 (16.2) years, 103 (52.3%) were male, and 156 (82.1%) were black. Severe COVID-19 infection was noted in 74 (37.6%) patients, requiring intubation. Patients aged above 60 were significantly more likely to have severe infection. Patients with severe infection were significantly more likely to have diabetes, renal disease, and chronic pulmonary disease and had significantly higher white blood cell counts, lower lymphocyte counts, and increased C-reactive protein (CRP) than patients with nonsevere infection. In multivariable logistic regression analysis, risk factors for severe infection included pre-existing renal disease (odds ratio [OR], 7.4; 95% CI, 2.5-22.0), oxygen requirement at hospitalization (OR, 2.9; 95% CI, 1.3-6.7), acute renal injury (OR, 2.7; 95% CI, 1.3-5.6), and CRP on admission (OR, 1.006; 95% CI, 1.001-1.01). Race, age, and socioeconomic status were not independent predictors. CONCLUSIONS: Acute or pre-existing renal disease, supplemental oxygen upon hospitalization, and admission CRP were independent predictors for the development of severe COVID-19. Every 1-unit increase in CRP increased the risk of severe disease by 0.06%.
BACKGROUND:COVID-19 is a pandemic disease caused by a novel coronavirus, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Predictors for severe COVID-19infection have not been well defined. Determination of risk factors for severe infection would enable identifying patients who may benefit from aggressive supportive care and early intervention. METHODS: We conducted a retrospective observational study of 197 patients with confirmed COVID-19 admitted to a tertiary academic medical center. RESULTS: Of 197 hospitalized patients, the mean (SD) age of the cohort was 60.6 (16.2) years, 103 (52.3%) were male, and 156 (82.1%) were black. Severe COVID-19infection was noted in 74 (37.6%) patients, requiring intubation. Patients aged above 60 were significantly more likely to have severe infection. Patients with severe infection were significantly more likely to have diabetes, renal disease, and chronic pulmonary disease and had significantly higher white blood cell counts, lower lymphocyte counts, and increased C-reactive protein (CRP) than patients with nonsevere infection. In multivariable logistic regression analysis, risk factors for severe infection included pre-existing renal disease (odds ratio [OR], 7.4; 95% CI, 2.5-22.0), oxygen requirement at hospitalization (OR, 2.9; 95% CI, 1.3-6.7), acute renal injury (OR, 2.7; 95% CI, 1.3-5.6), and CRP on admission (OR, 1.006; 95% CI, 1.001-1.01). Race, age, and socioeconomic status were not independent predictors. CONCLUSIONS: Acute or pre-existing renal disease, supplemental oxygen upon hospitalization, and admission CRP were independent predictors for the development of severe COVID-19. Every 1-unit increase in CRP increased the risk of severe disease by 0.06%.
Authors: Minesh Khatri; David M Charytan; Sam Parnia; Christopher M Petrilli; Jeffrey Michael; David Liu; Vasishta Tatapudi; Simon Jones; Judith Benstein; Leora I Horwitz Journal: Kidney360 Date: 2021-05-06
Authors: José Luis Piñana; Rodrigo Martino; Irene García-García; Rocío Parody; María Dolores Morales; Gonzalo Benzo; Irene Gómez-Catalan; Rosa Coll; Ignacio De La Fuente; Alejandro Luna; Beatriz Merchán; Anabelle Chinea; Dunia de Miguel; Ana Serrano; Carmen Pérez; Carola Diaz; José Luis Lopez; Adolfo Jesús Saez; Rebeca Bailen; Teresa Zudaire; Diana Martínez; Manuel Jurado; María Calbacho; Lourdes Vázquez; Irene Garcia-Cadenas; Laura Fox; Ana I Pimentel; Guiomar Bautista; Agustin Nieto; Pascual Fernandez; Juan Carlos Vallejo; Carlos Solano; Marta Valero; Ildefonso Espigado; Raquel Saldaña; Luisa Sisinni; Josep Maria Ribera; Maria Jose Jimenez; Maria Trabazo; Marta Gonzalez-Vicent; Noemí Fernández; Carme Talarn; Maria Carmen Montoya; Angel Cedillo; Anna Sureda Journal: Exp Hematol Oncol Date: 2020-08-25
Authors: JoonNyung Heo; Ji Ae Park; Deokjae Han; Hyung-Jun Kim; Daeun Ahn; Beomman Ha; Woong Seog; Yu Rang Park Journal: J Med Internet Res Date: 2020-11-04 Impact factor: 5.428