Literature DB >> 32472148

Is twice daily LF-rTMS a viable treatment option for treatment-resistant OCD? Results from an open-label feasibility study.

Hannelore L N Tandt1, Nele Van de Velde2, Sara De Witte3, Kurt Audenaert2,3, Chris Baeken2,3,4, Gilbert M D Lemmens2,3.   

Abstract

Several reports point to the beneficial effects of repetitive transcranial magnetic stimulation (rTMS) in the treatment of resistant obsessive-compulsive disorder (OCD). This study aimed to evaluate the safety and efficacy of rTMS targeting the dmPFC in the treatment of treatment-resistant OCD patients. Twelve patients received 20 sessions of low-frequency (LF) rTMS (1 Hz, 1200 pulses) in a twice daily protocol during 10 weekdays. Y-BOCS and IDS scores modestly but significantly decreased after treatment and at follow-up and HADS anxiety improved at follow-up. LF rTMS may improve OCD, anxiety, and depressive symptoms in treatment-resistant OCD and was a safe and well-tolerated treatment.

Entities:  

Keywords:  Efficacy; Obsessive–compulsive disorder; Repetitive transcranial magnetic stimulation; Safety

Mesh：

Year:  2020        PMID： 32472148     DOI： 10.1007/s00406-020-01142-x

Source DB:  PubMed          Journal:  Eur Arch Psychiatry Clin Neurosci        ISSN： 0940-1334            Impact factor:   5.270


  12 in total

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Journal:  Prog Neuropsychopharmacol Biol Psychiatry       Date:  2015-12-10       Impact factor: 5.067

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Journal:  Depress Anxiety       Date:  2015-03-31       Impact factor: 6.505

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Journal:  Acta Psychiatr Scand       Date:  1983-06       Impact factor: 6.392

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Authors:  A J Rush; C M Gullion; M R Basco; R B Jarrett; M H Trivedi
Journal:  Psychol Med       Date:  1996-05       Impact factor: 7.723

10.  Reductions in Cortico-Striatal Hyperconnectivity Accompany Successful Treatment of Obsessive-Compulsive Disorder with Dorsomedial Prefrontal rTMS.

Authors:  Katharine Dunlop; Blake Woodside; Marion Olmsted; Patricia Colton; Peter Giacobbe; Jonathan Downar
Journal:  Neuropsychopharmacology       Date:  2015-10-06       Impact factor: 7.853
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  1 in total

1.  Continuous Theta-Burst Stimulation Over the Right Orbitofrontal Cortex in Treatment-Resistant Obsessive-Compulsive Disorder Treatment: A Randomized Sham-Controlled Trial.

Authors:  Weiwei Liu; Hua Shao; Jing Liao; Dalu Yang; Maoliang Ma; Jianli Yang
Journal:  Int J Gen Med       Date:  2021-07-01
  1 in total

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