Amatallah Hussein Al-Rawhani1, Shaimaa Ismail Gawdat1, Suzan Abdul Wanees Amin2. 1. Department of Endodontics, Faculty of Dentistry, Cairo University, Cairo, Egypt. 2. Department of Endodontics, Faculty of Dentistry, Cairo University, Cairo, Egypt. Electronic address: suzan.wanis@dentistry.cu.edu.eg.
Abstract
INTRODUCTION: The aim of this prospective, randomized, double-blind, clinical trial was to evaluate the effect of a preoperative, single, oral dose of diclofenac potassium (DFK) on postoperative pain and rescue-analgesic intake in patients with symptomatic irreversible pulpitis (SIP) in mandibular molars treated in one visit. METHODS:Seventy emergency patients with moderate-to-severe preoperative pain randomly received either 50mg DFK or placebo tablets (PLC) one hour before starting endodontic treatment (n=35). Patients recorded their pain level 6, 12, 24 and 48h after treatment on a 170-mm Heft-Parker visual analogue scale. The incidence of rescue-analgesic intake was, also, recorded. Outcome data were statistically analyzed using Mann Whitney U, Friedman's test, Wilcoxon's sign rank and Chi2 (χ2) tests. Binary logistic regression assessed predisposing factors' association with postoperative pain. The significance level (α) was set at 0.05. RESULTS: Of the 70 patients, 68 were analyzed (n=34). Both groups had similar baseline characteristics (p>0.05). DFK showed significantly less pain incidence and intensity than PLC at 48h only (p<0.05). A significant decrease occurred from 24h to 48h with DFK (p<0.05) which was not recorded with PLC (p>0.05). No difference in the incidence of rescue-analgesic intake was reported between groups (p>0.05). Food-intake timing, gender, and rescue-analgesic intake were associated with postoperative pain (p<0.05). CONCLUSION: Premedication by a single, oral dose of 50 mg diclofenac potassium could be effective in reducing postendodontic pain at 48h after one-visit endodontic treatment in mandibular molars with SIP.
RCT Entities:
INTRODUCTION: The aim of this prospective, randomized, double-blind, clinical trial was to evaluate the effect of a preoperative, single, oral dose of diclofenac potassium (DFK) on postoperative pain and rescue-analgesic intake in patients with symptomatic irreversible pulpitis (SIP) in mandibular molars treated in one visit. METHODS: Seventy emergency patients with moderate-to-severe preoperative pain randomly received either 50mg DFK or placebo tablets (PLC) one hour before starting endodontic treatment (n=35). Patients recorded their pain level 6, 12, 24 and 48h after treatment on a 170-mm Heft-Parker visual analogue scale. The incidence of rescue-analgesic intake was, also, recorded. Outcome data were statistically analyzed using Mann Whitney U, Friedman's test, Wilcoxon's sign rank and Chi2 (χ2) tests. Binary logistic regression assessed predisposing factors' association with postoperative pain. The significance level (α) was set at 0.05. RESULTS: Of the 70 patients, 68 were analyzed (n=34). Both groups had similar baseline characteristics (p>0.05). DFK showed significantly less pain incidence and intensity than PLC at 48h only (p<0.05). A significant decrease occurred from 24h to 48h with DFK (p<0.05) which was not recorded with PLC (p>0.05). No difference in the incidence of rescue-analgesic intake was reported between groups (p>0.05). Food-intake timing, gender, and rescue-analgesic intake were associated with postoperative pain (p<0.05). CONCLUSION: Premedication by a single, oral dose of 50 mg diclofenac potassium could be effective in reducing postendodontic pain at 48h after one-visit endodontic treatment in mandibular molars with SIP.
Authors: Amir Azarpazhooh; Anibal R Diogenes; Ashraf F Fouad; Gerald N Glickman; Anil Kishen; Linda Levin; Robert S Roda; Christine M Sedgley; Franklin R Tay; Kenneth M Hargreaves Journal: J Endod Date: 2020-08 Impact factor: 4.171