Adrienne Lenhart1, Bruce Naliboff1,2, Wendy Shih3, Arpana Gupta1,2, Kirsten Tillisch1,2, Cathy Liu1,2, Emeran A Mayer1,2, Lin Chang1,2. 1. Vatche and Tamar Manoukian Division of Digestive Diseases, David Geffen School of Medicine, University of California, Los Angeles, CA, USA. 2. G Oppenheimer Center for Neurobiology of Stress and Resilience, University of California, Los Angeles, CA, USA. 3. Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles, CA, USA.
Abstract
BACKGROUND: Although irritable bowel syndrome (IBS) is more common in women, little is known about the role of hormonal changes and menopause in IBS. This study aimed to evaluate for differences in gastrointestinal (GI) and psychological symptoms between pre- and postmenopausal women with IBS compared to age-matched men with IBS. METHODS: Patients with Rome-positive IBS were identified. Premenopausal women were <45 years of age with regular menses. Postmenopausal women were ≥45 years without menses for at least 1 year. Younger men were <45 years, and older men were ≥45 years. Questionnaires measured severity of IBS symptoms, somatic symptoms, health-related quality of life (HRQOL), and psychological symptoms. Multivariable linear or logistic regressions evaluating relationships between age and sex were performed. KEY RESULTS: 190 premenopausal women (mean age 30.25 years), 52 postmenopausal women (mean age 54.38 years), 190 men <45 years (mean age 30.45 years), and 52 men ≥45 years (mean age 53.37 years) were included. Postmenopausal IBS women had greater severity of IBS symptoms (P = .003) and worse physical HRQOL (P = .048) compared to premenopausal women. No differences were observed between age-matched older and younger IBS men. Constipation increased with age for both sexes but was the principal IBS subtype in women only. CONCLUSIONS AND INFERENCES: Postmenopausal women with IBS have more severe IBS symptoms than premenopausal women, while no comparable age-related changes were seen in IBS men. The modulatory effect of female sex hormones on brain-gut interactions which affect visceral perception and GI function likely contributes to these findings.
BACKGROUND: Although irritable bowel syndrome (IBS) is more common in women, little is known about the role of hormonal changes and menopause in IBS. This study aimed to evaluate for differences in gastrointestinal (GI) and psychological symptoms between pre- and postmenopausal women with IBS compared to age-matched men with IBS. METHODS:Patients with Rome-positive IBS were identified. Premenopausal women were <45 years of age with regular menses. Postmenopausal women were ≥45 years without menses for at least 1 year. Younger men were <45 years, and older men were ≥45 years. Questionnaires measured severity of IBS symptoms, somatic symptoms, health-related quality of life (HRQOL), and psychological symptoms. Multivariable linear or logistic regressions evaluating relationships between age and sex were performed. KEY RESULTS: 190 premenopausal women (mean age 30.25 years), 52 postmenopausal women (mean age 54.38 years), 190 men <45 years (mean age 30.45 years), and 52 men ≥45 years (mean age 53.37 years) were included. Postmenopausal IBSwomenhad greater severity of IBS symptoms (P = .003) and worse physical HRQOL (P = .048) compared to premenopausal women. No differences were observed between age-matched older and younger IBSmen. Constipation increased with age for both sexes but was the principal IBS subtype in women only. CONCLUSIONS AND INFERENCES: Postmenopausal women with IBS have more severe IBS symptoms than premenopausal women, while no comparable age-related changes were seen in IBSmen. The modulatory effect of female sex hormones on brain-gut interactions which affect visceral perception and GI function likely contributes to these findings.
Authors: Xiaoshan Du; Shuai Liu; Peifei Jia; Xiaodan Wang; Jinghuan Gan; Wenzheng Hu; Han Zhu; Yehua Song; Jianping Niu; Yong Ji Journal: Front Public Health Date: 2022-06-15
Authors: Michelle Y Nabi; Samal Nauhria; Morgan Reel; Simon Londono; Anisha Vasireddi; Mina Elmiry; Prakash V A K Ramdass Journal: Front Med (Lausanne) Date: 2022-07-25
Authors: Małgorzata Kałużna; Agnieszka Nomejko; Aleksandra Słowińska; Katarzyna Wachowiak-Ochmańska; Katarzyna Pikosz; Katarzyna Ziemnicka; Marek Ruchała Journal: Endocr Connect Date: 2021-08-30 Impact factor: 3.335