Carlotta Cocchetti1, Jiska Ristori1, Alessia Romani1, Mario Maggi2, Alessandra Daphne Fisher1. 1. Andrology, Women's Endocrinology and Gender Incongruence Unit, Florence University Hospital, 50139 Florence, Italy. 2. Department of Experimental, Clinical and Biomedical Sciences, Careggi University Hospital, 50139 Florence, Italy.
Abstract
INTRODUCTION: To date no standardized hormonal treatment protocols for non-binary transgender individuals have been described in the literature and there is a lack of data regarding their efficacy and safety. OBJECTIVES: To suggest possible treatment strategies for non-binary transgender individuals with non-standardized requests and to emphasize the importance of a personalized clinical approach. METHODS: A narrative review of pertinent literature on gender-affirming hormonal treatment in transgender persons was performed using PubMed. RESULTS: New hormonal treatment regimens outside those reported in current guidelines should be considered for non-binary transgender individuals, in order to improve psychological well-being and quality of life. In the present review we suggested the use of hormonal and non-hormonal compounds, which-based on their mechanism of action-could be used in these cases depending on clients' requests. CONCLUSION: Requests for an individualized hormonal treatment in non-binary transgender individuals represent a future challenge for professionals managing transgender health care. For each case, clinicians should balance the benefits and risks of a personalized non-standardized treatment, actively involving the person in decisions regarding hormonal treatment.
INTRODUCTION: To date no standardized hormonal treatment protocols for non-binary transgender individuals have been described in the literature and there is a lack of data regarding their efficacy and safety. OBJECTIVES: To suggest possible treatment strategies for non-binary transgender individuals with non-standardized requests and to emphasize the importance of a personalized clinical approach. METHODS: A narrative review of pertinent literature on gender-affirming hormonal treatment in transgender persons was performed using PubMed. RESULTS: New hormonal treatment regimens outside those reported in current guidelines should be considered for non-binary transgender individuals, in order to improve psychological well-being and quality of life. In the present review we suggested the use of hormonal and non-hormonal compounds, which-based on their mechanism of action-could be used in these cases depending on clients' requests. CONCLUSION: Requests for an individualized hormonal treatment in non-binary transgender individuals represent a future challenge for professionals managing transgender health care. For each case, clinicians should balance the benefits and risks of a personalized non-standardized treatment, actively involving the person in decisions regarding hormonal treatment.
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