Literature DB >> 3246536

Determination of clozapine in human serum by capillary gas chromatography.

K Richter1.   

Abstract

A gas chromatographic method using a fused-silica wide-bore capillary column and a nitrogen-specific detector for the determination of the antipsychotic agent clozapine in human serum is described. This method was found to be suitable for the determination of serum levels down to 1-2 ng/ml. The sensitivity, precision and accuracy of this method are adequate for studies on pharmacokinetics and bioavailability.

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Year:  1988        PMID: 3246536     DOI: 10.1016/s0378-4347(88)80014-8

Source DB:  PubMed          Journal:  J Chromatogr


  5 in total

Review 1.  Clozapine plasma level monitoring: current status.

Authors:  T B Cooper
Journal:  Psychiatr Q       Date:  1996

Review 2.  Clozapine. A review of its pharmacological properties, and therapeutic use in schizophrenia.

Authors:  A Fitton; R C Heel
Journal:  Drugs       Date:  1990-11       Impact factor: 9.546

3.  Rapid liquid chromatography/tandem mass spectrometer (LCMS) method for clozapine and its metabolite N-desmethyl clozapine (norclozapine) in human serum.

Authors:  L V Rao; M L Snyder; G M Vallaro
Journal:  J Clin Lab Anal       Date:  2009       Impact factor: 2.352

Review 4.  Pharmacokinetics and pharmacodynamics of clozapine.

Authors:  M W Jann; S R Grimsley; E C Gray; W H Chang
Journal:  Clin Pharmacokinet       Date:  1993-02       Impact factor: 6.447

5.  Effect of switching carbamazepine to oxcarbazepine on the plasma levels of neuroleptics. A case report.

Authors:  V Raitasuo; R Lehtovaara; M O Huttunen
Journal:  Psychopharmacology (Berl)       Date:  1994-09       Impact factor: 4.530

  5 in total

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