György S Reusz1, Adrienn Bárczi2, Arianna Dégi2, Orsolya Cseprekál3, Éva Kis4, Ádám Szabó5, Monika Csóka6, Gábor Rudas5, Anna Végh2, Mohamed Temmar7, Paolo Salvi8. 1. 1st Department of Pediatrics, Semmelweis University, Budapest, Hungary. Electronic address: reusz.gyorgy@med.semmelweis-univ.hu. 2. 1st Department of Pediatrics, Semmelweis University, Budapest, Hungary. 3. Department of Surgery and Transplantation, Semmelweis University, Budapest, Hungary. 4. Gottsegen György Hungarian Institute of Cardiology, Budapest, Hungary. 5. Medical Imaging Centre, Department of Neuroradiology, Semmelweis University, Budapest, Hungary. 6. 2nd Department of Pediatrics, Semmelweis University, Budapest, Hungary. 7. Telomere Cardiology Center, Ghardaia, Algeria. 8. Istituto Auxologico Italiano, IRCCS, Cardiology Unit, Milan, Italy.
Abstract
BACKGROUND AND AIMS: Central pulse wave velocity (PWV) is a marker of arterial stiffness and is calculated by dividing the pulse wave travel distance by the transit time. However, there is no consensus as to the ideal distance measurement in children. The aim of our study was to identify the more reliable method to assess the distance measurement in the pediatric age. METHODS: Carotid-femoral PWV was measured by applanation tonometry in 988 healthy children aged 6.5-19.9 years. Two different surface distances were assessed: the subtraction method, representing the distance from the suprasternal notch to the femoral artery minus the distance from the carotid artery to the suprasternal notch, and the direct method, consisting of 80% of the distance from the carotid artery to the femoral artery. Both these methods were compared with the actual path length determined by magnetic resonance imaging (MRI) in 31 children. RESULTS: Subtraction and direct methods were significantly correlated in patients aged <14 years and the corresponding PWV values showed a good agreement. In children aged ≥14 years, a significant difference between the two methods was found: subtraction - direct distance = -45 ± 28 mm, with a significant difference in the resulting PWV values = -0.57 ± 0.35 m/s (p < 0.0001). This result was confirmed by MRI, showing a 10% overestimation in distance measurement by the direct method in subjects aged ≥14 years, resulting in a significantly higher PWV. CONCLUSIONS: These data suggest a greater reliability of the subtractive method of distance measurement compared to the direct method in children.
BACKGROUND AND AIMS: Central pulse wave velocity (PWV) is a marker of arterial stiffness and is calculated by dividing the pulse wave travel distance by the transit time. However, there is no consensus as to the ideal distance measurement in children. The aim of our study was to identify the more reliable method to assess the distance measurement in the pediatric age. METHODS: Carotid-femoral PWV was measured by applanation tonometry in 988 healthy children aged 6.5-19.9 years. Two different surface distances were assessed: the subtraction method, representing the distance from the suprasternal notch to the femoral artery minus the distance from the carotid artery to the suprasternal notch, and the direct method, consisting of 80% of the distance from the carotid artery to the femoral artery. Both these methods were compared with the actual path length determined by magnetic resonance imaging (MRI) in 31 children. RESULTS: Subtraction and direct methods were significantly correlated in patients aged <14 years and the corresponding PWV values showed a good agreement. In children aged ≥14 years, a significant difference between the two methods was found: subtraction - direct distance = -45 ± 28 mm, with a significant difference in the resulting PWV values = -0.57 ± 0.35 m/s (p < 0.0001). This result was confirmed by MRI, showing a 10% overestimation in distance measurement by the direct method in subjects aged ≥14 years, resulting in a significantly higher PWV. CONCLUSIONS: These data suggest a greater reliability of the subtractive method of distance measurement compared to the direct method in children.
Authors: Anna Végh; Adrienn Bárczi; Orsolya Cseprekál; Éva Kis; Kata Kelen; Szilárd Török; Attila J Szabó; György S Reusz Journal: Front Med (Lausanne) Date: 2021-12-16
Authors: Adrienn Bárczi; Bálint Károly Lakatos; Mónika Szilágyi; Éva Kis; Orsolya Cseprekál; Alexandra Fábián; Attila Kovács; Attila J Szabó; Béla Merkely; Paolo Salvi; György S Reusz Journal: Pediatr Nephrol Date: 2022-02-15 Impact factor: 3.651