| Literature DB >> 32464324 |
Yangmin Qiu1, Yue Cao1, Wangjia Cao1, Yifei Jia2, Na Lu3.
Abstract
Ferroptosis is a new kind of regulated cell death that is characterized by highly iron-dependent lipid peroxidation. Ferroptosis involves various biology processes, such as iron metabolism, lipid metabolism, oxidative stress and biosynthesis of nicotinamide adenine dinucleotide phosphate (NADPH), glutathione (GSH) and coenzyme Q10 (CoQ10). A growing body of evidence suggests that ferroptosis is associated with cancer and neurodegenerative diseases (Alzheimer's disease, Parkinson's disease and Huntington's disease). This finding has helped develop a novel cytoprotective strategy to protect cells in neurodegenerative, blood and heart diseases by inhibiting ferroptosis. Meanwhile, the selective induction of ferroptosis has been adopted as a potential treatment strategy in some kinds of cancer. This review aims to summarize the mechanism of ferroptosis regulation and relevance to pathological physiology.Entities:
Keywords: Deferasirox (PubChem CID: 214348); Deferoxamine (PubChem CID: 2973); Erastin (PubChem CID: 11214940); Ferrostatin-1 (PubChem CID: 4068248); Lapatinib (PubChem CID: 208908); RAS-selective lethal 3 (PubChem CID: 1750826); Sorafenib (PubChem CID: 216239); cancer; cell death; ferroptosis; iron metabolism; lipid peroxidation; reactive oxygen species
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Year: 2020 PMID： 32464324 DOI： 10.1016/j.phrs.2020.104919
Source DB: PubMed Journal: Pharmacol Res ISSN： 1043-6618 Impact factor: 7.658