Yuxiang Qi1, Yuling Gao1. 1. Department of Neurology, Shengli Oilfield Central Hospital, Dongying 257034, Shandong, China.
Abstract
Background: This study aimed to investigate the clinical significance of microRNA-33b (miR-33b) in glioma patients and its biological function in tumor progression. Materials & methods: Expression of miR-33b was measured using quantitative real-time RT-PCR. Diagnostic and prognostic values of miR-33b were assessed by the receiver operating characteristics curve and Kaplan-Meier (KM) survival assay. The functional role of miR-33b was further analyzed. Results: Expression of miR-33b in glioma patients and cells was decreased. Expression of miR-33b had high diagnostic accuracy and could predict a poor prognosis. Overexpression of miR-33b led to suppressed glioma cell proliferation, migration and invasion. Conclusion: Decreased expression of miR-33b serves a promising biomarker in the diagnosis and prognosis of glioma, and may be a potential therapeutic target.
Background: This study aimed to investigate the clinical significance of microRNA-33b (miR-33b) in gliomapatients and its biological function in tumor progression. Materials & methods: Expression of miR-33b was measured using quantitative real-time RT-PCR. Diagnostic and prognostic values of miR-33b were assessed by the receiver operating characteristics curve and Kaplan-Meier (KM) survival assay. The functional role of miR-33b was further analyzed. Results: Expression of miR-33b in gliomapatients and cells was decreased. Expression of miR-33b had high diagnostic accuracy and could predict a poor prognosis. Overexpression of miR-33b led to suppressed glioma cell proliferation, migration and invasion. Conclusion: Decreased expression of miR-33b serves a promising biomarker in the diagnosis and prognosis of glioma, and may be a potential therapeutic target.
Authors: Joshua J Levy; Youdinghuan Chen; Nasim Azizgolshani; Curtis L Petersen; Alexander J Titus; Erika L Moen; Louis J Vaickus; Lucas A Salas; Brock C Christensen Journal: NPJ Syst Biol Appl Date: 2021-08-20