Tommaso Zoerle1, Nino Stocchetti2,3. 1. Neuroscience Intensive Care Unit, Department of Anesthesia and Critical Care, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy. tommaso.zoerle@policlinico.mi.it. 2. Neuroscience Intensive Care Unit, Department of Anesthesia and Critical Care, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy. 3. Department of Pathophysiology and Transplantation, University of Milan, Milan, Italy.