Literature DB >> 32459999

Lipid in Renal Carcinoma: Queen Bee to Target?

Sze Kiat Tan1, Scott M Welford2.   

Abstract

Clear cell renal cell carcinoma (ccRCC) is the most common renal cancer subtype, characterized by a lipid storage phenotype. We found that carnitine palmitoyltransferase 1A (CPT1A), the rate-limiting enzyme of mitochondrial fatty acid (FA) transport, is repressed by hypoxia-inducible factors (HIFs), reducing FA oxidation (FAO). Altering lipid metabolism may be a new therapeutic avenue in ccRCC.
Copyright © 2020 Elsevier Inc. All rights reserved.

Entities:  

Keywords:  CPT1A; HIF; ccRCC; clear cell renal cell carcinoma; hypoxia; lipid metabolism

Mesh：

Substances：

Year:  2020        PMID： 32459999     DOI： 10.1016/j.trecan.2020.02.017

Source DB:  PubMed          Journal:  Trends Cancer        ISSN： 2405-8025


  7 in total

Review 1.  Fatty acid metabolism reprogramming in ccRCC: mechanisms and potential targets.

Authors:  Sze Kiat Tan; Helen Y Hougen; Jaime R Merchan; Mark L Gonzalgo; Scott M Welford
Journal:  Nat Rev Urol       Date:  2022-10-03       Impact factor: 16.430

2.  Obesity-Dependent Adipokine Chemerin Suppresses Fatty Acid Oxidation to Confer Ferroptosis Resistance.

Authors:  Sze Kiat Tan; Iqbal Mahmud; Flavia Fontanesi; Michelle Puchowicz; Chase K A Neumann; Anthony J Griswold; Rutulkumar Patel; Marco Dispagna; Hamzah H Ahmed; Mark L Gonzalgo; J Mark Brown; Timothy J Garrett; Scott M Welford
Journal:  Cancer Discov       Date:  2021-03-23       Impact factor: 39.397

3.  Revealing potential lipid biomarkers in clear cell renal cell carcinoma using targeted quantitative lipidomics.

Authors:  Wen Li; Xiaobin Wang; Xianbin Zhang; Peng Gong; Degang Ding; Ning Wang; Zhifeng Wang
Journal:  Lipids Health Dis       Date:  2021-11-13       Impact factor: 3.876

Review 4.  A Deep Insight Into Regulatory T Cell Metabolism in Renal Disease: Facts and Perspectives.

Authors:  Zhongyu Han; Kuai Ma; Hongxia Tao; Hongli Liu; Jiong Zhang; Xiyalatu Sai; Yunlong Li; Mingxuan Chi; Qing Nian; Linjiang Song; Chi Liu
Journal:  Front Immunol       Date:  2022-02-17       Impact factor: 7.561

5.  A Double-Negative Feedback Interaction between miR-21 and PPAR-α in Clear Renal Cell Carcinoma.

Authors:  Marine Goujon; Justine Woszczyk; Kelly Gaudelot; Thomas Swierczewski; Sandy Fellah; Jean-Baptiste Gibier; Isabelle Van Seuningen; Romain Larrue; Christelle Cauffiez; Viviane Gnemmi; Sébastien Aubert; Nicolas Pottier; Michaël Perrais
Journal:  Cancers (Basel)       Date:  2022-02-04       Impact factor: 6.639

6.  AUP1 regulates lipid metabolism and induces lipid accumulation to accelerate the progression of renal clear cell carcinoma.

Authors:  Chen Chen; Wei Zhao; Xingxing Lu; Yunbo Ma; Peizhi Zhang; Zicheng Wang; Zilian Cui; Qinghua Xia
Journal:  Cancer Sci       Date:  2022-06-27       Impact factor: 6.518

Review 7.  The emerging roles of TRIM21 in coordinating cancer metabolism, immunity and cancer treatment.

Authors:  Xintian Chen; Menghan Cao; Pengfei Wang; Sufang Chu; Minle Li; Pingfu Hou; Junnian Zheng; Zhongwei Li; Jin Bai
Journal:  Front Immunol       Date:  2022-09-09       Impact factor: 8.786
  7 in total

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