Literature DB >> 32459998

Towards the Microbial Production of Plant-Derived Anticancer Drugs.

Vincent Courdavault1, Sarah E O'Connor2, Audrey Oudin3, Sébastien Besseau3, Nicolas Papon4.   

Abstract

Many of the plant-derived compounds used in chemotherapies are currently produced by semisynthesis, which results in limited supplies at exorbitant market prices. However, the synthetic biology era, which began ca 15 years ago, has progressively yielded encouraging advances by using engineered microbes for the practical production of cheaper plant anticancer drugs.
Copyright © 2020 Elsevier Inc. All rights reserved.

Keywords:  metabolic engineering; microorganisms; plant; specialized metabolites; synthetic biology

Mesh：

Substances：

Year:  2020        PMID： 32459998     DOI： 10.1016/j.trecan.2020.02.004

Source DB:  PubMed          Journal:  Trends Cancer        ISSN： 2405-8025


  7 in total

1.  Phytochemical profiling and cytotoxic evaluation of Premna serratifolia L. against human liver cancer cell line.

Authors:  Kavindra Nath Tiwari; Sunil Kumar Mishra; Poonam Kakkar; Chandrashekhar Singh; Sumit Kumar Anand
Journal:  3 Biotech       Date:  2021-02-05       Impact factor: 2.406

2.  Identifying Genes Involved in alkaloid Biosynthesis in Vinca minor Through Transcriptomics and Gene Co-Expression Analysis.

Authors:  Emily Amor Stander; Liuda Johana Sepúlveda; Thomas Dugé de Bernonville; Inês Carqueijeiro; Konstantinos Koudounas; Pamela Lemos Cruz; Sébastien Besseau; Arnaud Lanoue; Nicolas Papon; Nathalie Giglioli-Guivarc'h; Ron Dirks; Sarah Ellen O'Connor; Lucia Atehortùa; Audrey Oudin; Vincent Courdavault
Journal:  Biomolecules       Date:  2020-11-24

3.  Naringin induces apoptosis of gastric carcinoma cells via blocking the PI3K/AKT pathway and activating pro‑death autophagy.

Authors:  Cuixiang Xu; Xiaoyan Huang; Yubin Huang; Xiao Liu; Min Wu; Jianhua Wang; Xianglong Duan
Journal:  Mol Med Rep       Date:  2021-09-07       Impact factor: 2.952

4.  Metabolic pathway assembly using docking domains from type I cis-AT polyketide synthases.

Authors:  Xixi Sun; Yujie Yuan; Qitong Chen; Shiqi Nie; Jiaxuan Guo; Zutian Ou; Min Huang; Zixin Deng; Tiangang Liu; Tian Ma
Journal:  Nat Commun       Date:  2022-09-21       Impact factor: 17.694

Review 5.  Alkaloids in Contemporary Drug Discovery to Meet Global Disease Needs.

Authors:  Sharna-Kay Daley; Geoffrey A Cordell
Journal:  Molecules       Date:  2021-06-22       Impact factor: 4.411

Review 6.  Deploying Microbial Synthesis for Halogenating and Diversifying Medicinal Alkaloid Scaffolds.

Authors:  Samuel A Bradley; Jie Zhang; Michael K Jensen
Journal:  Front Bioeng Biotechnol       Date:  2020-10-23

7.  Enhanced bioproduction of anticancer precursor vindoline by yeast cell factories.

Authors:  Natalja Kulagina; Grégory Guirimand; Céline Melin; Pamela Lemos-Cruz; Ines Carqueijeiro; Johan-Owen De Craene; Audrey Oudin; Vladimir Heredia; Konstantinos Koudounas; Marianne Unlubayir; Arnaud Lanoue; Nadine Imbault; Benoit St-Pierre; Nicolas Papon; Marc Clastre; Nathalie Giglioli-Guivarc'h; Jillian Marc; Sébastien Besseau; Vincent Courdavault
Journal:  Microb Biotechnol       Date:  2021-07-24       Impact factor: 5.813
  7 in total

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