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Literature DB >> 3245862

Experimental intracerebral haemorrhage: the effect of nimodipine pretreatment.

E J Sinar¹, A D Mendelow, D I Graham, G M Teasdale.

Abstract

The effect of pretreatment with the calcium antagonist nimodipine on the pathophysiological events which follow an intracerebral haemorrhage in rats was compared with a similar control group. Cerebral blood flow was higher and the amount of pathologically determined ischaemic damage measured by light microscopy was less in the nimodipine pretreated group. Bloodbrain barrier permeability was increased in the nimodipine group, but there was no evidence of cerebral oedema. Nimodipine appeared to have no effect on the intracranial pressure.

Entities: Chemical Disease Species

Mesh：

Substances：
Nimodipine
Oxygen

Year: 1988 PMID： 3245862 PMCID： PMC1033071 DOI： 10.1136/jnnp.51.5.651

Source DB: PubMed Journal: J Neurol Neurosurg Psychiatry ISSN： 0022-3050 Impact factor: 10.154

30 in total

1. Surgery of cerebral hemorrhage; report on the results of 52 surgically treated cases.

Authors: G LAZORTHES
Journal: J Neurosurg Date: 1959-07 Impact factor: 5.115

2. The nature, distribution and earliest stages of anoxic-ischaemic nerve cell damage in the rat brain as defined by the optical microscope.

Authors: A W Brown; J B Brierley
Journal: Br J Exp Pathol Date: 1968-04

3. Measurement of local cerebral blood flow in the unanesthetized rat using a hydrogen clearance method.

Authors: J L Haining; M D Turner; R M Pantall
Journal: Circ Res Date: 1968-08 Impact factor: 17.367

4. The threshold and neuropathology of cerebral "anoxic-ischemic" cell change.

Authors: J B Brierley; B S Meldrum; A W Brown
Journal: Arch Neurol Date: 1973-12

5. Effects of experimental intracerebral hemorrhage on blood flow, capillary permeability, and histochemistry.

Authors: F P Nath; P T Kelly; A Jenkins; A D Mendelow; D I Graham; G M Teasdale
Journal: J Neurosurg Date: 1987-04 Impact factor: 5.115

6. Experimental intracerebral hemorrhage: effects of a temporary mass lesion.

Authors: E J Sinar; A D Mendelow; D I Graham; G M Teasdale
Journal: J Neurosurg Date: 1987-04 Impact factor: 5.115

7. Evaluation of the efficacy of intrathecal nimodipine in canine models of chronic cerebral vasospasm.

Authors: A E Gioia; R P White; B Bakhtian; J T Robertson
Journal: J Neurosurg Date: 1985-05 Impact factor: 5.115

8. Intracranial haemorrhage induced at arterial pressure in the rat. Part 2: Short term changes in local cerebral blood flow measured by autoradiography.

Authors: A D Mendelow; R Bullock; G M Teasdale; D I Graham; J McCulloch
Journal: Neurol Res Date: 1984-12 Impact factor: 2.448

9. Nimodipine improves outcome when given after complete cerebral ischemia in primates.

Authors: P A Steen; S E Gisvold; J H Milde; L A Newberg; B W Scheithauer; W L Lanier; J D Michenfelder
Journal: Anesthesiology Date: 1985-04 Impact factor: 7.892

10. Effect of pretreatment with the calcium antagonist nimodipine on local cerebral blood flow and histopathology after middle cerebral artery occlusion.

Authors: A A Mohamed; O Gotoh; D I Graham; K A Osborne; J McCulloch; A D Mendelow; G M Teasdale; A M Harper
Journal: Ann Neurol Date: 1985-12 Impact factor: 10.422

3 in total