| Literature DB >> 32458261 |
Karima Riane1, Mohamed Sifour2, Houria Ouled-Haddar1, Cristobal Espinosa3, Maria A Esteban3, Mesbah Lahouel1.
Abstract
In this study, we have investigated the effect of an antioxidant probiotic pretreatment toward an overdose of diclofenac in rats (100 mg/kg bw). Rats were treated daily with the probiotic Streptococcus salivarius St.sa (109 CFU) during seven successive days and then received a single treatment with diclofenac overdose in distilled water. Liver transaminases (alanine aminotransferase, aspartate aminotransferase, and alkaline phosphatase), histology, glutathione (GSH) and malondialdehyde (MDA) level were investigated. In addition, both antioxidant enzyme activity and its mRNA gene expression were studied to evaluate diclofenac hepatotoxicity. The results indicated that probiotic pretreatment reduced diclofenac-induced hepatotoxicity through enhancement of the studied hepatic markers and regulation of antioxidant enzyme expression and activity. These findings indicate that the probiotic pretreatment protects rat liver against the oxidative stress induced by diclofenac overdose.Entities:
Keywords: Antioxidant enzymes; Diclofenac; Hepatotoxicity; Oxidative stress; Probiotic; Streptococcus salivarius
Year: 2020 PMID： 32458261 PMCID： PMC7688739 DOI： 10.1007/s42770-020-00302-4
Source DB: PubMed Journal: Braz J Microbiol ISSN： 1517-8382 Impact factor: 2.476