Literature DB >> 32457485

RHPN1-AS1 promotes cell proliferation and migration via miR-665/Akt3 in ovarian cancer.

Juan Zhao1, Ting Yang1, Jing Ji1, Fan Zhao1, Chen Li1, Xiaobing Han2.   

Abstract

Recent efforts have revealed that long non-coding RNAs exert crucial roles in cancer initiation and progression. RHPN1-AS1 is a 2030 bp transcript from human chromosome 8q24, and involved in tumorigenesis in uveal melanoma and non-small cell lung cancer, but it remains unknown in ovarian cancer. This study focused on the role of RHPN1-AS1 in ovarian cancer and found that RHPN1-AS1 was up-regulated in ovarian cancer tissues and cell lines. Overexpression of RHPN1-AS1 promoted ovarian cancer cell proliferation, migration, and invasion. Mechanistically, overexpression of RHPN1-AS1 decreased the expression of miR-665 and subsequently promoted the expression of Akt3 at posttranscriptional level. Taken together, RHPN1-AS1 positively regulated the expression of Akt3 through sponging miR-665, and exerted an oncogenic role in ovarian cancer progression, and indicates that RHPN1-AS1 may be a potential therapeutic target in ovarian cancer.

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Year:  2020        PMID： 32457485     DOI： 10.1038/s41417-020-0180-0

Source DB:  PubMed          Journal:  Cancer Gene Ther        ISSN： 0929-1903            Impact factor:   5.987


  1 in total

1.  MicroRNA‑665 suppresses the growth and migration of ovarian cancer cells by targeting HOXA10.

Authors:  Jinhui Liu; Yi Jiang; Yicong Wan; Shulin Zhou; Sunita Thapa; Wenjun Cheng
Journal:  Mol Med Rep       Date:  2018-07-05       Impact factor: 2.952
  1 in total
  8 in total

1.  MicroRNA-665 regulates the proliferation, apoptosis and adhesion of gastric cancer cells by binding to cadherin 3.

Authors:  Xinhui Fang; Yangqiu Bai; Lida Zhang; Songze Ding
Journal:  Oncol Lett       Date:  2021-04-26       Impact factor: 2.967

2.  RHPN1‑AS1 promotes ovarian carcinogenesis by sponging miR‑485‑5p and releasing TPX2 mRNA.

Authors:  Shoubin Cui; Cui Li
Journal:  Oncol Rep       Date:  2021-04-28       Impact factor: 3.906

3.  Integrated analysis of 1804 samples of six centers to construct and validate a robust immune-related prognostic signature associated with stromal cell abundance in tumor microenvironment for gastric cancer.

Authors:  Junyu Huo; Ge Guan; Jinzhen Cai; Liqun Wu
Journal:  World J Surg Oncol       Date:  2022-01-05       Impact factor: 2.754

4.  RHPN1‑AS1 promotes ovarian carcinogenesis by sponging miR‑6884‑5p thus releasing TOP2A mRNA.

Authors:  Shoubin Cui; Fengling Li
Journal:  Oncol Rep       Date:  2021-08-20       Impact factor: 3.906

5.  AGTR1 Inhibits the Progression of Lung Adenocarcinoma.

Authors:  Lecai Xiong; Yanhong Wei; Xiao Zhou; Peng Dai; Yi Cai; Xuefeng Zhou; Ming Xu; Jinping Zhao; Hexiao Tang
Journal:  Cancer Manag Res       Date:  2021-11-13       Impact factor: 3.989

6.  Rhophilin rho GTPase binding protein 1-antisense RNA 1 (RHPN1-AS1) promotes ovarian carcinogenesis by sponging microRNA-485-5p and releasing DNA topoisomerase II alpha (TOP2A).

Authors:  Yi Zhou; Jing Li; Xiaoxin Yang; Yu Song; Haigang Li
Journal:  Bioengineered       Date:  2021-12       Impact factor: 3.269

7.  Hypomethylation-driven AKT Serine/Threonine Kinase 3 promotes testicular germ cell tumors proliferation and negatively correlates to immune infiltration.

Authors:  Yang Luo; Qianyin Zhou; Fang Zhu; Liqing Fan; Hao Bo; Xingming Wang
Journal:  Bioengineered       Date:  2021-12       Impact factor: 3.269

8.  LncRNA RPSAP52 promotes cell proliferation and inhibits cell apoptosis via modulating miR-665/STAT3 in gastric cancer.

Authors:  Chao He; Yuanyuan Liu; Jinhou Li; Xiao Zheng; Jianwei Liang; Gang Cui; Hong Chang
Journal:  Bioengineered       Date:  2022-04       Impact factor: 6.832
  8 in total

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