Local Use of Apisan Gel, A New Oral Care Product in the Treatment of Experimental Periodontitis Against the Background of Hyperacid Gastritis and Intoxication with Tobacco Smoke.

OBJECTIVES: The aim of the work was to substantiate the use of a newly created oral care product in the treatment of periodontal disease reconstructed against the background of hyperacidic gastritis under the conditions of tobacco smoke intoxication.
MATERIALS AND METHODS: The study was conducted in 2 stages. In the first stage, all experimental animals were divided into 4 groups: 1) intact, 2) with simulated periodontitis, 3) with reproduced periodontitis against the background of reproduced hyperacidic gastritis, 4) with reproduced periodontitis against the background of hyperacid gastritis under the conditions of tobacco smoking. Biochemical studies of gum homogenate with periodontitis in rats were conducted to determine the impact of stomach pathology and tobacco smoke as endogenous and exogenous risk factors. In stage 2, the effectiveness of local therapy with the use of the newly created oral care product and a comparator was studied in rats with reproduced periodontitis against the background of hyperacidic gastritis under the conditions of smoking.
RESULTS: In the experimental periodontitis against the background of hyperacidic gastritis under the conditions of tobacco smoking, there were significant changes in the periodontal tissues characteristic of the inflammatory process: the activity of peroxide oxidation of lipid (POL) increased, activity of the antioxidant system decreased, and inflammatory markers increased when nonspecific protection was reduced. Local therapy in the rats using the new "Apisan" gel resulted in the correction of certain metabolic disorders, faster elimination of the harmful effects of the damaging factors, and restoration of the condition of periodontal tissues compared with the use of the comparator, the Asepta gel.
CONCLUSION: The therapeutic effectiveness of the new Apisan gel is due to the normalizing effect on the processes of POL, and inflammation and activation of the oral cavity protective systems during inflammatory periodontal disease occurring against the background of a concomitant stomach pathology, hyperacidic gastritis. ©Copyright 2020 Turk J Pharm Sci, Published by Galenos Publishing House.