Gülsel Yurtdaş Kirimlioğlu1, A Alper Öztürk1.
Abstract
OBJECTIVES: The aim of the present study was to formulate levocetirizine hydrochloride (LCD)-loaded chitosan nanoparticles at submicron level with high entrapment efficiency and prolonged effect for optimizing the plasma drug concentration enhancing bioavailability.
MATERIALS AND METHODS: LCD was successfully incorporated into chitosan nanoparticles by spray drying for the purpose of oral application. In vitro characteristics were evaluated in detail.
RESULTS: LCD was successfully loaded into the polymeric matrices by spray drying. Characterization of the nanoparticles including encapsulation efficiency, particle size, zeta potential, morphology, polydispersity index, solid-state characterizations, and LCD quantification by high performance liquid chromatography was performed. The release pattern of LCD from the nanoparticles was determined using a dialysis tube in simulated intestinal fluid (pH 6.8). In vitro release profiles indicated prolonged release of LCD from the nanoparticles that followed the Korsmeyer-Peppas kinetic model.
CONCLUSION: Chitosan-based LCD-loaded polymeric nanoparticles appear to be a promising drug delivery system for the active agent. ©Copyright 2020 Turk J Pharm Sci, Published by Galenos Publishing House.
OBJECTIVES: The aim of the present study was to formulate levocetirizine hydrochloride (LCD)-loaded chitosan nanoparticles at submicron level with high entrapment efficiency and prolonged effect for optimizing the plasma drug concentration enhancing bioavailability.
MATERIALS AND METHODS: LCD was successfully incorporated into chitosan nanoparticles by spray drying for the purpose of oral application. In vitro characteristics were evaluated in detail.
RESULTS: LCD was successfully loaded into the polymeric matrices by spray drying. Characterization of the nanoparticles including encapsulation efficiency, particle size, zeta potential, morphology, polydispersity index, solid-state characterizations, and LCD quantification by high performance liquid chromatography was performed. The release pattern of LCD from the nanoparticles was determined using a dialysis tube in simulated intestinal fluid (pH 6.8). In vitro release profiles indicated prolonged release of LCD from the nanoparticles that followed the Korsmeyer-Peppas kinetic model.
CONCLUSION: Chitosan-based LCD-loaded polymeric nanoparticles appear to be a promising drug delivery system for the active agent. ©Copyright 2020 Turk J Pharm Sci, Published by Galenos Publishing House.
Entities:
Keywords:
Levocetirizine dihydrochloride; chitosan; polymeric nanoparticle; spray drying
Year: 2020
PMID： 32454757 PMCID： PMC7227860 DOI： 10.4274/tjps.galenos.2018.34392
Source DB: PubMed Journal: Turk J Pharm Sci ISSN： 1304-530X