Sathiya Ramu 1 , Shwetha Krishna Murthy 1 , Sukanya Krishna 1 , Abhishek Lakkasandra Somashekaraiah 1 , Vani B Nandihalli 1 , Kanekal Mohammed Muzammil 1 Show Affiliations »
Abstract
OBJECTIVES: Tamarindus indica L. is known to be a multipurpose traditional plant in India. It is used to treat some bacterial infections, parasitic infestations, constipation, and inflammation. It is also used as a blood tonic and for wound healing. This study was designed to substantiate the traditional claim of haematinic activity for T. indica. MATERIALS AND METHODS: T. indica leaf extract was formulated into an oral indiffusible mixture (TIM) and evaluated for its haematinic activity in phenylhydrazine (single dose of 10 mg/kg per oral for 8 days) induced anaemia. Wistar rats were grouped into six (n=6). Groups I and II served as normal control and disease control groups, respectively. Group III received the standard drug (haematinic suspension 2 mL/kg). Groups IV, V, and VI received the formulated oral indiffusible mixture of T. indica at a dose of 100, 200, and 400 mg/kg, respectively. RESULTS: The TIM was formulated and pharmaceutically optimized. It produced significant increases in red blood cells, hemoglobin, and packed cell volume and a decrease in mean corpuscular volume. CONCLUSION: The results showed that the treatment with TIM reversed phenylhydrazine induced anemia. However, the short duration of the present study is regarded as a limitation, and therefore a longer duration is required for obtaining better responses. ©Copyright 2019 Turk J Pharm Sci, Published by Galenos Publishing House.
OBJECTIVES: Tamarindus indica L. is known to be a multipurpose traditional plant in India. It is used to treat some bacterial infections, parasitic infestations, constipation, and inflammation. It is also used as a blood tonic and for wound healing. This study was designed to substantiate the traditional claim of haematinic activity for T. indica. MATERIALS AND METHODS: T. indica leaf extract was formulated into an oral indiffusible mixture (TIM) and evaluated for its haematinic activity in phenylhydrazine (single dose of 10 mg/kg per oral for 8 days) induced anaemia. Wistar rats were grouped into six (n=6). Groups I and II served as normal control and disease control groups, respectively. Group III received the standard drug (haematinic suspension 2 mL/kg). Groups IV, V, and VI received the formulated oral indiffusible mixture of T. indica at a dose of 100, 200, and 400 mg/kg, respectively. RESULTS: The TIM was formulated and pharmaceutically optimized. It produced significant increases in red blood cells, hemoglobin, and packed cell volume and a decrease in mean corpuscular volume. CONCLUSION: The results showed that the treatment with TIM reversed phenylhydrazine induced anemia. However, the short duration of the present study is regarded as a limitation, and therefore a longer duration is required for obtaining better responses. ©Copyright 2019 Turk J Pharm Sci, Published by Galenos Publishing House.
Entities: Chemical
Keywords:
Tamarindus indica; haematinic activity; phenylhydrazine
Year: 2018
PMID： 32454691 PMCID： PMC7227988 DOI： 10.4274/tjps.77598
Source DB: PubMed Journal: Turk J Pharm Sci ISSN： 1304-530X