Çiğdem Kahraman 1 , İffet İrem Tatli 2 , Didem Kart 3 , Melike Ekizoğlu 3 , Zeliha Şükran Akdemir 1 Show Affiliations »
Abstract
OBJECTIVES: To determine the secondary metabolites from Verbascum mucronatum Lam. and evaluate their antimicrobial activity. MATERIALS AND METHODS: Antimicrobial activities of the isolated metabolites were determined using broth microdilutions against the bacteria (Escherichia coli ATCC 25922, Enterococcus faecalis ATCC 29212, Pseudomonas aeruginosa ATCC 27853, Staphylococcus aureus ATCC 29213) and fungi (Candida albicans ATCC 90028, Candida krusei ATCC 6258, Candida parapsilosis ATCC 90018). RESULTS: Four iridoid glycosides; ajugol (1), aucubin (2), lasianthoside I (3), catalpol (4), two triterpenic saponins; ilwensisaponin C (5), ilwensisaponin A (=mimengoside A) (6), and one phenylethanoid glycoside; verbascoside (=acteoside) (7) were isolated from the water soluble parts of the methanolic extract gained flowery parts of V. mucronatum Lam. CONCLUSION: Within the obtained compounds, ajugol and ilwensisaponin A showed moderate antimicrobial activity, especially against fungi. ©Copyright 2018 Turk J Pharm Sci, Published by Galenos Publishing House.
OBJECTIVES: To determine the secondary metabolites from Verbascum mucronatum Lam. and evaluate their antimicrobial activity. MATERIALS AND METHODS: Antimicrobial activities of the isolated metabolites were determined using broth microdilutions against the bacteria (Escherichia coli ATCC 25922, Enterococcus faecalis ATCC 29212, Pseudomonas aeruginosa ATCC 27853, Staphylococcus aureus ATCC 29213) and fungi (Candida albicans ATCC 90028, Candida krusei ATCC 6258, Candida parapsilosis ATCC 90018). RESULTS: Four iridoid glycosides; ajugol (1), aucubin (2), lasianthoside I (3), catalpol (4), two triterpenic saponins; ilwensisaponin C (5), ilwensisaponin A (=mimengoside A) (6), and one phenylethanoid glycoside; verbascoside (=acteoside) (7) were isolated from the water soluble parts of the methanolic extract gained flowery parts of V. mucronatum Lam. CONCLUSION: Within the obtained compounds, ajugol and ilwensisaponin A showed moderate antimicrobial activity, especially against fungi. ©Copyright 2018 Turk J Pharm Sci, Published by Galenos Publishing House.
Entities: Chemical
Keywords:
Scrophulariaceae; Verbascum mucronatum Lam.; antimicrobial activity; secondary metabolites
Year: 2018
PMID： 32454665 PMCID： PMC7227826 DOI： 10.4274/tjps.50479
Source DB: PubMed Journal: Turk J Pharm Sci ISSN： 1304-530X