Literature DB >> 32454599

Flavin Containing Monooxygenases and Metabolism of Xenobiotics.

Rahman Başaran1, Benay Can Eke1.   

Abstract

This review summarizes recent information concerning the pharmacological and toxicological significance of the flavin-containing monooxygenases (FMOs). FMOs are a family of microsomal enzymes involving in the oxygenation of certain xenobiotics and drugs containing nucleophilic heteroatoms. The activities of FMOs in drug metabolism and their relationships with diseases are the areas of research requiring further exploration. Future studies on FMOs may provide considerable information about the pathophysiology of diseases and the information related to this enzyme family may be important for drug designs in future. ©Copyright 2017 Turk J Pharm Sci, Published by Galenos Publishing House.

Entities:  

Keywords:  Flavin monooxygenase; microsomal enzymes; phase 1 reactions

Year:  2017        PMID： 32454599      PMCID： PMC7227999          DOI： 10.4274/tjps.30592

Source DB:  PubMed          Journal:  Turk J Pharm Sci        ISSN： 1304-530X


  38 in total

Review 1.  Biochemical and clinical aspects of the human flavin-containing monooxygenase form 3 (FMO3) related to trimethylaminuria.

Authors:  John R Cashman; Kathryn Camp; Steven S Fakharzadeh; Paul V Fennessey; Ronald N Hines; Orval A Mamer; Steven C Mitchell; George Preti Nguyen; Daniel Schlenk; Robert L Smith; Susan S Tjoa; David E Williams; Steven Yannicelli
Journal:  Curr Drug Metab       Date:  2003-04       Impact factor: 3.731

Review 2.  Flavin-containing monooxygenases: catalytic mechanism and substrate specificities.

Authors:  D M Ziegler
Journal:  Drug Metab Rev       Date:  1988       Impact factor: 4.518

3.  Tissue-specific expression of flavin-containing monooxygenase (FMO) forms 1 and 2 in the rabbit.

Authors:  S E Shehin-Johnson; D E Williams; S Larsen-Su; D M Stresser; R N Hines
Journal:  J Pharmacol Exp Ther       Date:  1995-03       Impact factor: 4.030

4.  Identification of distinct hepatic and pulmonary forms of microsomal flavin-containing monooxygenase in the mouse and rabbit.

Authors:  R E Tynes; P J Sabourin; E Hodgson
Journal:  Biochem Biophys Res Commun       Date:  1985-02-15       Impact factor: 3.575

5.  Effect of salinity on flavin-containing monooxygenase expression and activity in rainbow trout (Oncorhynchus mykiss).

Authors:  B K Larsen; D Schlenk
Journal:  J Comp Physiol B       Date:  2001-06       Impact factor: 2.200

6.  Genetic polymorphisms of human flavin monooxygenase 3 in sulindac-mediated primary chemoprevention of familial adenomatous polyposis.

Authors:  Irfan M Hisamuddin; Mohammad A Wehbi; Ann Chao; Hadley W Wyre; Linda M Hylind; Francis M Giardiello; Vincent W Yang
Journal:  Clin Cancer Res       Date:  2004-12-15       Impact factor: 12.531

Review 7.  Interindividual differences of human flavin-containing monooxygenase 3: genetic polymorphisms and functional variation.

Authors:  John R Cashman; Jun Zhang
Journal:  Drug Metab Dispos       Date:  2002-10       Impact factor: 3.922

8.  Insulin in flavin-containing monooxygenase regulation. Flavin-containing monooxygenase and cytochrome P450 activities in experimental diabetes.

Authors:  Tímea Borbás; Bernadett Benko; Balázs Dalmadi; Imola Szabó; Károly Tihanyi
Journal:  Eur J Pharm Sci       Date:  2006-02-20       Impact factor: 4.384

9.  A nomenclature for the mammalian flavin-containing monooxygenase gene family based on amino acid sequence identities.

Authors:  M P Lawton; J R Cashman; T Cresteil; C T Dolphin; A A Elfarra; R N Hines; E Hodgson; T Kimura; J Ozols; I R Phillips
Journal:  Arch Biochem Biophys       Date:  1994-01       Impact factor: 4.013

Review 10.  Multisubstrate flavin-containing monooxygenases: applications of mechanism to specificity.

Authors:  L L Poulsen; D M Ziegler
Journal:  Chem Biol Interact       Date:  1995-04-28       Impact factor: 5.192
View more
  6 in total

1.  Identification and Quantification of MIDD0301 Metabolites.

Authors:  M S Rashid Roni; Nicolas M Zahn; Brandon N Mikulsky; Daniel A Webb; Md Yeunus Mian; Daniel E Knutson; Margaret L Guthrie; James M Cook; Douglas C Stafford; Leggy A Arnold
Journal:  Curr Drug Metab       Date:  2021       Impact factor: 3.731

2.  Inhibition of cytochrome P450 enhances the nephro- and hepatotoxicity of ochratoxin A.

Authors:  Gisela H Degen; Jan G Hengstler; Ahmed Ghallab; Reham Hassan; Daniela González; Zaynab Hobloss; Lisa Brackhagen; Maiju Myllys; Adrian Friebel; Abdel-Latif Seddek; Rosemarie Marchan; Benedikt Cramer; Hans-Ulrich Humpf; Stefan Hoehme
Journal:  Arch Toxicol       Date:  2022-10-13       Impact factor: 6.168

Review 3.  Roles of selected non-P450 human oxidoreductase enzymes in protective and toxic effects of chemicals: review and compilation of reactions.

Authors:  Slobodan P Rendić; Rachel D Crouch; F Peter Guengerich
Journal:  Arch Toxicol       Date:  2022-06-01       Impact factor: 6.168

4.  Variation in 100 relevant pharmacogenes among emiratis with insights from understudied populations.

Authors:  Zeina N Al-Mahayri; George P Patrinos; Sukanya Wattanapokayakit; Nareenart Iemwimangsa; Koya Fukunaga; Taisei Mushiroda; Wasun Chantratita; Bassam R Ali
Journal:  Sci Rep       Date:  2020-12-04       Impact factor: 4.379

Review 5.  Properties and Mechanisms of Flavin-Dependent Monooxygenases and Their Applications in Natural Product Synthesis.

Authors:  Yaming Deng; Quan Zhou; Yuzhou Wu; Xi Chen; Fangrui Zhong
Journal:  Int J Mol Sci       Date:  2022-02-27       Impact factor: 5.923

Review 6.  Camel Proteins and Enzymes: A Growing Resource for Functional Evolution and Environmental Adaptation.

Authors:  Mahmoud Kandeel; Abdulla Al-Taher; Katharigatta N Venugopala; Mohamed Marzok; Mohamed Morsy; Sreeharsha Nagaraja
Journal:  Front Vet Sci       Date:  2022-07-12
  6 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.