Müslüm Kuzu 1 , Ahmet Özkaya 2 , Zafer Şahin 3 , Üzeyir Dağ 2 , Veysel Çomakli 4 , Ramazan Demirdağ 4 Show Affiliations »
Abstract
OBJECTIVES: Carbonic anhydrase (CA) enzyme catalyses the reversible reactions of CO2 with water and takes part in metabolically important events such as systemic acid-base regulation and respiration. In this study, in vivo effects of lead, which is a heavy metal and to which living beings are exposed by different ways, with naringenin, a flavanone, were investigated. MATERIALS AND METHODS: For this purpose, four different rat groups were established and one of them was chosen as the control group. The other three groups were given lead, naringenin and lead+naringenin substances to analyze the changes in the CA enzyme of rat erythrocytes. RESULTS: The research findings showed that the enzyme activity in the control group was higher than that in the other groups. The naringenin group showed the highest inhibition effect, while the lead group showed the lowest inhibition. CONCLUSION: Therefore, it can be said that naringenin is a strong inhibitor of the CA enzyme. ©Copyright 2017 Turk J Pharm Sci, Published by Galenos Publishing House.
OBJECTIVES: Carbonic anhydrase (CA) enzyme catalyses the reversible reactions of CO2 with water and takes part in metabolically important events such as systemic acid-base regulation and respiration. In this study, in vivo effects of lead, which is a heavy metal and to which living beings are exposed by different ways, with naringenin, a flavanone, were investigated. MATERIALS AND METHODS: For this purpose, four different rat groups were established and one of them was chosen as the control group. The other three groups were given lead, naringenin and lead+naringenin substances to analyze the changes in the CA enzyme of rat erythrocytes. RESULTS: The research findings showed that the enzyme activity in the control group was higher than that in the other groups. The naringenin group showed the highest inhibition effect, while the lead group showed the lowest inhibition. CONCLUSION: Therefore, it can be said that naringenin is a strong inhibitor of the CA enzyme. ©Copyright 2017 Turk J Pharm Sci, Published by Galenos Publishing House.
Entities: Chemical
Keywords:
Carbonic anhydrase; inhibition; lead; naringenin
Year: 2017
PMID： 32454588 PMCID： PMC7227992 DOI： 10.4274/tjps.13008
Source DB: PubMed Journal: Turk J Pharm Sci ISSN： 1304-530X