BACKGROUND: A relevant case of pulmonary sporotrichosis due to Sporothrix brasiliensis is reported in a 50-year-old immunocompetent woman who had no history of skin trauma, but was in close contact with several stray cats at her nap time. The patient was hospitalized after 7 months of illness. The survey was conducted for pulmonary tuberculosis, an endemic disease in Brazil. She presented multiple central pulmonary nodules images, with central cavitation. METHODOLOGY/PRINCIPAL FINDINGS: The patient bronchoalveolar lavage was cultured and Sporothrix sp. growth was obtained. Then, the isolate (LMMM1097) was accurately identified to the species level by using species-specific polymerase chain reaction (PCR). Molecular diagnosis revealed that the emerging species Sporothrix brasiliensis was the agent of primary pulmonary sporotrichosis and the patient was treated with Amphotericin B lipid complex, but presented severe clinical symptoms and the fatal outcome was observed at day 25 after hospitalization. CONCLUSIONS/SIGNIFICANCE: Our report adds important contributions to the clinical-epidemiological features of sporotrichosis, showing the geographic expansion of the agent within different regions of Brazil and a rare clinical manifestation (primary pulmonary sporotrichosis) caused by the emerging agent S. brasiliensis in an immunocompetent female patient.
BACKGROUND: A relevant case of pulmonary sporotrichosis due to Sporothrix brasiliensis is reported in a 50-year-old immunocompetent woman who had no history of skin trauma, but was in close contact with several stray cats at her nap time. The patient was hospitalized after 7 months of illness. The survey was conducted for pulmonary tuberculosis, an endemic disease in Brazil. She presented multiple central pulmonary nodules images, with central cavitation. METHODOLOGY/PRINCIPAL FINDINGS: The patient bronchoalveolar lavage was cultured and Sporothrix sp. growth was obtained. Then, the isolate (LMMM1097) was accurately identified to the species level by using species-specific polymerase chain reaction (PCR). Molecular diagnosis revealed that the emerging species Sporothrix brasiliensis was the agent of primary pulmonary sporotrichosis and the patient was treated with Amphotericin B lipid complex, but presented severe clinical symptoms and the fatal outcome was observed at day 25 after hospitalization. CONCLUSIONS/SIGNIFICANCE: Our report adds important contributions to the clinical-epidemiological features of sporotrichosis, showing the geographic expansion of the agent within different regions of Brazil and a rare clinical manifestation (primary pulmonary sporotrichosis) caused by the emerging agent S. brasiliensis in an immunocompetent female patient.
Authors: Rigoberto Hernández-Castro; Rodolfo Pinto-Almazán; Roberto Arenas; Carlos Daniel Sánchez-Cárdenas; Víctor Manuel Espinosa-Hernández; Karla Yaeko Sierra-Maeda; Esther Conde-Cuevas; Eder R Juárez-Durán; Juan Xicohtencatl-Cortes; Erika Margarita Carrillo-Casas; Jimmy Steven-Velásquez; Erick Martínez-Herrera; Carmen Rodríguez-Cerdeira Journal: J Fungi (Basel) Date: 2022-05-30
Authors: Vivian Fichman; Dayvison Francis Saraiva Freitas; Antonio Carlos Francesconi do Valle; Rogerio Valls de Souza; André Luiz Land Curi; Cláudia Maria Valete-Rosalino; Priscila Marques de Macedo; Andréa Gina Varon; Maria Helena Galdino Figueiredo-Carvalho; Fernando Almeida-Silva; Rosely Maria Zancopé-Oliveira; Raquel de Vasconcelos Carvalhaes Oliveira; Rodrigo Almeida-Paes; Maria Clara Gutierrez-Galhardo Journal: J Fungi (Basel) Date: 2022-04-30