Anam Javaid 1 , Usman Ali Ashfaq 1 , Zeeshan Zafar 1 , Arina Akmal 1 , Saman Taj 1 , Hina Khalid 1 Show Affiliations »
Abstract
Aims & Objective: Armoracia rusticana has high medicinal values and is an excellent source of phytochemicals. This study was aimed to evaluate the antidiabetic potential of bioactive compounds from Armoracia rusticana. METHODS: The antidiabetic analysis revealed that Armoracia rusticana was highly active against α- glucosidase with IC50 values of 5.6 μg/ml. Furthermore, molecular docking was used to identify the active constituents against α-glucosidase, while using acarbose as a controlled drug. RESULTS: Upon phytochemical screening, it was found that six out of ten phytochemicals were successfully docked in the respective binding sites. The lead phytochemical was Quercetin 3-Obeta- D-xylopyranoside, which displayed a more binding score as compared to acarbose. They were subjected to analyze for drug-like properties, which further strengthen its validation. CONCLUSION: It was, therefore, concluded that Armoracia rusticana might potentially be used in the amelioration of type 2 diabetes. Potential molecules identified from this study could be considered as a lead drug to cure diabetes mellitus. Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.net.
Aims & Objective: Armoracia rusticana has high medicinal values and is an excellent source of phytochemicals. This study was aimed to evaluate the antidiabetic potential of bioactive compounds from Armoracia rusticana . METHODS: The antidiabetic analysis revealed that Armoracia rusticana was highly active against α- glucosidase with IC50 values of 5.6 μg/ml. Furthermore, molecular docking was used to identify the active constituents against α-glucosidase, while using acarbose as a controlled drug. RESULTS: Upon phytochemical screening, it was found that six out of ten phytochemicals were successfully docked in the respective binding sites. The lead phytochemical was Quercetin 3-Obeta- D-xylopyranoside, which displayed a more binding score as compared to acarbose . They were subjected to analyze for drug-like properties, which further strengthen its validation. CONCLUSION: It was, therefore, concluded that Armoracia rusticana might potentially be used in the amelioration of type 2 diabetes . Potential molecules identified from this study could be considered as a lead drug to cure diabetes mellitus . Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.net.
Entities: Chemical
Disease
Species
Keywords:
Anti-diabetic; Armoracia rusticana; alpha-glucosidase; docking; enzyme inhibition assay; phytochemicals
Year: 2021
PMID： 32452324 DOI： 10.2174/1386207323666200526134512
Source DB: PubMed Journal: Comb Chem High Throughput Screen ISSN： 1386-2073 Impact factor: 1.339