Literature DB >> 32451226

The Helicobacter pylori Cag Type IV Secretion System.

Timothy L Cover1, D Borden Lacy2, Melanie D Ohi3.   

Abstract

Colonization of the human stomach with Helicobacter pylori strains containing the cag pathogenicity island is a risk factor for development of gastric cancer. The cag pathogenicity island contains genes encoding a secreted effector protein (CagA) and components of a type IV secretion system (Cag T4SS). The molecular architecture of the H. pylori Cag T4SS is substantially more complex than that of prototype T4SSs in other bacterial species. In this review, we discuss recent discoveries pertaining to the structure and function of the Cag T4SS and its role in gastric cancer pathogenesis. Published by Elsevier Ltd.

Entities:  

Keywords:  bacterial nanomachines; bacterial protein secretion; cryo-electron microscopy; cryo-electron tomography; gastric adenocarcinoma; gastric cancer; macromolecular structures; peptic ulcer disease; type IV secretion system

Mesh：

Substances：

Year:  2020        PMID： 32451226      PMCID： PMC7363556          DOI： 10.1016/j.tim.2020.02.004

Source DB:  PubMed          Journal:  Trends Microbiol        ISSN： 0966-842X            Impact factor:   17.079


  102 in total

1.  Systematic mutagenesis of the Helicobacter pylori cag pathogenicity island: essential genes for CagA translocation in host cells and induction of interleukin-8.

Authors:  W Fischer; J Püls; R Buhrdorf; B Gebert; S Odenbreit; R Haas
Journal:  Mol Microbiol       Date:  2001-12       Impact factor: 3.501

2.  CagA protein secreted by the intact type IV secretion system leads to gastric epithelial inflammation in the Mongolian gerbil model.

Authors:  W Shibata; Y Hirata; S Maeda; K Ogura; T Ohmae; A Yanai; Y Mitsuno; Y Yamaji; M Okamoto; H Yoshida; T Kawabe; M Omata
Journal:  J Pathol       Date:  2006-11       Impact factor: 7.996

3.  Biological Diversity and Evolution of Type IV Secretion Systems.

Authors:  Peter J Christie; Laura Gomez Valero; Carmen Buchrieser
Journal:  Curr Top Microbiol Immunol       Date:  2017       Impact factor: 4.291

4.  The Helicobacter pylori virulence effector CagA abrogates human β-defensin 3 expression via inactivation of EGFR signaling.

Authors:  Bianca Bauer; Ervinna Pang; Carsten Holland; Mirjana Kessler; Sina Bartfeld; Thomas F Meyer
Journal:  Cell Host Microbe       Date:  2012-06-14       Impact factor: 21.023

5.  Tolerance rather than immunity protects from Helicobacter pylori-induced gastric preneoplasia.

Authors:  Isabelle C Arnold; Josephine Y Lee; Manuel R Amieva; Axel Roers; Richard A Flavell; Tim Sparwasser; Anne Müller
Journal:  Gastroenterology       Date:  2010-06-22       Impact factor: 22.682

Review 6.  Helicobacter pylori in health and disease.

Authors:  Timothy L Cover; Martin J Blaser
Journal:  Gastroenterology       Date:  2009-05-07       Impact factor: 22.682

7.  Cloning and expression of a high-molecular-mass major antigen of Helicobacter pylori: evidence of linkage to cytotoxin production.

Authors:  M K Tummuru; T L Cover; M J Blaser
Journal:  Infect Immun       Date:  1993-05       Impact factor: 3.441

8.  The bacterial virulence factor CagA induces microbial dysbiosis that contributes to excessive epithelial cell proliferation in the Drosophila gut.

Authors:  Tiffani Alvey Jones; Diane Z Hernandez; Zoë C Wong; Anica M Wandler; Karen Guillemin
Journal:  PLoS Pathog       Date:  2017-10-19       Impact factor: 6.823

9.  Transgenic expression of the Helicobacter pylori virulence factor CagA promotes apoptosis or tumorigenesis through JNK activation in Drosophila.

Authors:  Anica M Wandler; Karen Guillemin
Journal:  PLoS Pathog       Date:  2012-10-18       Impact factor: 6.823

10.  Integrin but not CEACAM receptors are dispensable for Helicobacter pylori CagA translocation.

Authors:  Qing Zhao; Benjamin Busch; Luisa Fernanda Jiménez-Soto; Hellen Ishikawa-Ankerhold; Steffen Massberg; Laurent Terradot; Wolfgang Fischer; Rainer Haas
Journal:  PLoS Pathog       Date:  2018-10-26       Impact factor: 6.823
View more
  16 in total

1.  Positive Selection of Mutations in the Helicobacter pylori katA 5' Untranslated Region in a Mongolian Gerbil Model of Gastric Disease.

Authors:  John T Loh; Jennifer H B Shuman; Aung Soe Lin; Natalie Favret; M Blanca Piazuelo; Simon Mallal; Abha Chopra; Mark S McClain; Timothy L Cover
Journal:  Infect Immun       Date:  2022-06-02       Impact factor: 3.609

Review 2.  Emerging role of human microbiome in cancer development and response to therapy: special focus on intestinal microflora.

Authors:  Hourieh Sadrekarimi; Zhanna R Gardanova; Morteza Bakhshesh; Farnoosh Ebrahimzadeh; Amirhossein Fakhre Yaseri; Lakshmi Thangavelu; Zahra Hasanpoor; Firoozeh Abolhasani Zadeh; Mohammad Saeed Kahrizi
Journal:  J Transl Med       Date:  2022-07-06       Impact factor: 8.440

Review 3.  The Importance of CXCL1 in the Physiological State and in Noncancer Diseases of the Oral Cavity and Abdominal Organs.

Authors:  Jan Korbecki; Iwona Szatkowska; Patrycja Kupnicka; Wojciech Żwierełło; Katarzyna Barczak; Iwona Poziomkowska-Gęsicka; Jerzy Wójcik; Dariusz Chlubek; Irena Baranowska-Bosiacka
Journal:  Int J Mol Sci       Date:  2022-06-28       Impact factor: 6.208

Review 4.  Biomarker Characterization and Prediction of Virulence and Antibiotic Resistance from Helicobacter pylori Next Generation Sequencing Data.

Authors:  Joana S Vital; Luís Tanoeiro; Ricardo Lopes-Oliveira; Filipa F Vale
Journal:  Biomolecules       Date:  2022-05-11

Review 5.  Type IV secretion systems: Advances in structure, function, and activation.

Authors:  Tiago R D Costa; Laith Harb; Pratick Khara; Lanying Zeng; Bo Hu; Peter J Christie
Journal:  Mol Microbiol       Date:  2021-01-07       Impact factor: 3.501

6.  Lipoprotein Processing and Sorting in Helicobacter pylori.

Authors:  Mark S McClain; Bradley J Voss; Timothy L Cover
Journal:  mBio       Date:  2020-05-19       Impact factor: 7.867

7.  Diversity of 3' variable region of cagA gene in Helicobacter pylori strains isolated from Chinese population.

Authors:  Zhijing Xue; Yuanhai You; Lihua He; Yanan Gong; Lu Sun; Xiurui Han; Ruyue Fan; Kangle Zhai; Yaming Yang; Maojun Zhang; Xiaomei Yan; Jianzhong Zhang
Journal:  Gut Pathog       Date:  2021-04-13       Impact factor: 4.181

8.  Effectors of the Stenotrophomonas maltophilia Type IV Secretion System Mediate Killing of Clinical Isolates of Pseudomonas aeruginosa.

Authors:  Megan Y Nas; Jeffrey Gabell; Nicholas P Cianciotto
Journal:  mBio       Date:  2021-06-29       Impact factor: 7.867

9.  Tracking bacterial effector protein delivery into host cells.

Authors:  Timothy L Cover
Journal:  Mol Microbiol       Date:  2021-07-28       Impact factor: 3.979

10.  Cryo-EM reveals species-specific components within the Helicobacter pylori Cag type IV secretion system core complex.

Authors:  Michael J Sheedlo; Jeong Min Chung; Neha Sawhney; Clarissa L Durie; Timothy L Cover; Melanie D Ohi; D Borden Lacy
Journal:  Elife       Date:  2020-09-02       Impact factor: 8.140
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.