Shuifang Xiao1, Jinrang Li2, Hongliang Zheng3, Yan Yan4, Xiangping Li5, Lihong Zhang6, Quiping Lv7, Junbo Zhang8, Lin Zeng9, Xia Gao10, Xiong Chen11,12, Hui Yang13, Chen Zhao14, Jian Zhang15, Honghua Lu16, Xianyang Luo17, Guangke Wang18, Hongliang Yi19, Jin Ye20, Zhenqun Lin21, Linli Tian22, Jingjing Zhang23, Ting Chen24, Aimin Yu25, Zhaohui Liu26, Xiaoyong Ren27, Xinming Yang28, Siyi Zhang29, Xiaobo Cui30, Gelin Li31, Guanglun Wan32, Chang Lin33, Hui Chen34, Anchun Deng35, Xiabing Tang36, Qingfeng Zhang37,38, Zhenfeng Tao39, Li Shi40, Jianyong Zhou41, Gang Qin42, Peiyun Zhuang43, Hui Huangfu44, Jianming Yang45, Guojin Zhou46, Huijun Li47, Wei Wu48, Julan Li49, Shuhua Li50, Guangming Lou51, Hongyan Fang52, Jiangang Ma53, Chunguang Shan53, Xuejun Zhou54, Liang Tang55, Fang Zhou56, Yunping Fan57, Yanping Zhang58, Yujie Li59, Meisheng Li60, Chunqiang Dou61, Zhiling Chen62, Gang Lei63, Jingbo Li64, Zhiguang Gao65, Yongwang Huang66, Xinchun Ma67, Zhijun Liu68, Gengtian Liang69, Jian He70, Hua Zhao71, Bailong Song72, Meijun Chen73, Xiangli Yang74, Zuopeng Ma75, Jinlong Ren76. 1. Department of Otorhinolaryngology, Head and Neck Surgery, Peking University First Hospital, 8# Xishiku Street, Western District, Beijing, 100034, China. xiao_ent@163.com. 2. Department of Otorhinolaryngology, Head and Neck Surgery, The Sixth Medical Center of Chinese PLA General Hospital, 6# Fucheng Road, Haidian District, Beijing, 100048, China. entljr@sina.com. 3. Department of Otorhinolaryngology, Head and Neck Surgery, Changhai Hospital, Second Military Medical University, 168# Changhai Street, Yangpu District, Shanghai, 200433, China. zheng_hl2004@163.com. 4. Department of Otorhinolaryngology, Head and Neck Surgery, Peking University Third Hospital, Beijing, China. 5. Department of Otorhinolaryngology, Head and Neck Surgery, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, China. 6. Department of Otorhinolaryngology, Head and Neck Surgery, Peking University People's Hospital, Beijing, China. 7. Department of Otorhinolaryngology, Head and Neck Surgery, China-Japan Friendship Hospital, Beijing, China. 8. Department of Otorhinolaryngology, Head and Neck Surgery, Peking University First Hospital, 8# Xishiku Street, Western District, Beijing, 100034, China. 9. Research Center of Clinical Epidemiology, Peking University Third Hospital, Beijing, China. 10. Department of Otorhinolaryngology, Head and Neck Surgery, Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing, Jiangsu, China. 11. Department of Otorhinolaryngology, Head and Neck Surgery, Zhongnan Hospital of Wuhan University, Wuhan, Hubei, China. 12. Department of Otorhinolaryngology, Head and Neck Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China. 13. Department of Otorhinolaryngology, Head and Neck Surgery, West China Hospital of Sichuan University, Chengdu, Sichuan, China. 14. Department of Otorhinolaryngology, Head and Neck Surgery, The First Affiliated Hospital of China Medical University, Shenyang, Liaoning, China. 15. Department of Otorhinolaryngology Head and Neck Surgery, The First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, China. 16. Department of Otorhinolaryngology, Head and Neck Surgery, Tianjin First Central Hospital, Tianjin, China. 17. Department of Otorhinolaryngology, Head and Neck Surgery, The First Affiliated Hospital of Xiamen University, Xiamen, Fujian, China. 18. Department of Otorhinolaryngology Head and Neck Surgery, Henan Provincial People's Hospital, Zhengzhou, Henan, China. 19. Department of Otorhinolaryngology, Head and Neck Surgery, Affiliated Sixth People's Hospital of Shanghai Jiaotong University, Shanghai, China. 20. Department of Otorhinolaryngology, Head and Neck Surgery, The Third Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, China. 21. Department of Otorhinolaryngology, Head and Neck Surgery, Hainan Provincial People's Hospital, Hiakou, Hainan, China. 22. Department of Otorhinolaryngology, Head and Neck Surgery, The Second Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang, China. 23. Department of Otorhinolaryngology, Peking University Shenzhen Hospital, Shenzhen, Guangdong, China. 24. Department of Otorhinolaryngology, Head and Neck Surgery, Fujian Provincial Hospital, Fuzhou, Fujian, China. 25. Department of Otorhinolaryngology, Head and Neck Surgery, Clinical Medical School, Yangzhou University, Yangzhou, Jiangsu, China. 26. Department of Otorhinolaryngology, Head and Neck Surgery, Affiliated Hospital of Zunyi Medical College, Zunyi, Guizhou, China. 27. Department of Otorhinolaryngology, Head and Neck Surgery, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, China. 28. Department of Otorhinolaryngology Head and Neck Surgery, The Second Xiangya Hospital, Central South University, Changsha, Hunan, China. 29. Department of Otorhinolaryngology Head and Neck Surgery, Guangdong Provincial People's Hospital, Guangzhou, Guangdong, China. 30. Department of Otorhinolaryngology Head and Neck Surgery, Affiliated Hospital of Inner Mongolia Medical University, Hohhot, Inner Mongolia, China. 31. Department of Otorhinolaryngology, Head and Neck Surgery, Beijing Friendship Hospital, Capital Medical University, Beijing, China. 32. Department of Otolaryngology, Head and Neck Surgery, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Anhui Provincial Hospital, Hefei, Anhui, China. 33. Department of Otorhinolaryngology, Head and Neck Surgery, The First Affiliated Hospital of Fujian Medical University, Fuzhou, Fujian, China. 34. Department of Otorhinolaryngology, Head and Neck Surgery, Chengdu First People's Hospital, Chengdu, Sichuan, China. 35. Department of Otorhinolaryngology, Head and Neck Surgery, Xinqiao Hospital, Army Military Medical University, Chongqing, China. 36. Department of Otorhinolaryngology, Head and Neck Surgery, Wuxi People's Hospital, Wuxi, Jiangsu, China. 37. Department of Otorhinolaryngology, Head and Neck Surgery, Dalian Central Hospital, Dalian, Liaoning, China. 38. Department of Otorhinolaryngology, Head and Neck Surgery, Shenzhen University General Hospital, Shenzhen, Guangdong, China. 39. Department of Otorhinolaryngology, Head and Neck Surgery, Bethune International Peace Hospital, Shijiazhuang, Hebei, China. 40. Department of Otorhinolaryngology, Head and Neck Surgery, Xijing Hospital, Air Force Military Medical University, Xi'an, Shaanxi, China. 41. Department of Otorhinolaryngology Head and Neck Surgery, Jiangmen Central Hospital, Jiangmen, Guangdong, China. 42. Department of Otorhinolaryngology, Head and Neck Surgery, Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan, China. 43. Department of Voice, Zhongshan Hospital, Xiamen University, Xiamen, Fujian, China. 44. Department of Otorhinolaryngology, Head and Neck Surgery, The First Hospital of Shanxi Medical University, Taiyuan, Shanxi, China. 45. Department of Otorhinolaryngology, Head and Neck Surgery, The Second Affiliated Hospital of Anhui Medical University, Hefei, Anhui, China. 46. Department of Otorhinolaryngology, Head and Neck Surgery, Sir Run Run Shaw Hospital, Zhejiang University, Hangzhou, Zhejiang, China. 47. Department of Otorhinolaryngology, Head and Neck Surgery, The First Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang, China. 48. Department of Otorhinolaryngology, Head and Neck Surgery, PLA Strategic Support Force Characteristic Medical Center, Beijing, China. 49. Department of Otorhinolaryngology Head and Neck Surgery, Sichuan Provincial Corps Hospital, Chinese People's Armed Police Force, Leshan, Sichuan, China. 50. Department of Otorhinolaryngology Head and Neck Surgery, General Hospital of Northern Theater Command, Shenyang, Liaoning, China. 51. Department of Otorhinolaryngology Head and Neck Surgery, The First Hospital of Longyan City, Longyan, Fujian, China. 52. Department of Otorhinolaryngology Head and Neck Surgery, Chongqing General Hospital, Chongqing, China. 53. Department of Otorhinolaryngology, Head and Neck Surgery, The Second Hospital of Hebei Medical University, Shijiazhuang, Hebei, China. 54. Department of Otorhinolaryngology, Head and Neck Surgery, The First Affiliated Hospital of Hainan Medical College, Haikou, Hainan, China. 55. Department of Otorhinolaryngology, Head and Neck Surgery, The People's Hospital of Xinjiang Uygur Autonomous Region, Urumqi, Xinjiang, China. 56. Department of Otorhinolaryngology Head and Neck Surgery, Changsha Central Hospital, Changsha, Hunan, China. 57. Department of Otorhinolaryngology Head and Neck Surgery, The Fifth Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, China. 58. Department of Otorhinolaryngology Head and Neck Surgery, The 8th Medical Center of Chinese PLA General Hospital, Beijing, China. 59. Department of Otorhinolaryngology Head and Neck Surgery, Zhengzhou Central Hospital, Zhengzhou, Henan, China. 60. Department of Otorhinolaryngology Head and Neck Surgery, The First People's Hospital of Shangqiu City, Shangqiu, Henan, China. 61. Department of Otorhinolaryngology, Head and Neck Surgery, Linfen People's Hospital, Linfen, Shanxi, China. 62. Department of Otorhinolaryngology, Head and Neck Surgery, Hangzhou Hospital of Traditional Chinese Medicine, Hangzhou, Zhejiang, China. 63. Department of Otorhinolaryngology Head and Neck Surgery, Chongqing Hospital of Traditional Chinese Medicine, Chongqing, China. 64. Department of Otorhinolaryngology Head and Neck Surgery, Henan Provincial Hospital of Traditional Chinese Medicine, Zhengzhou, Henan, China. 65. Department of Otorhinolaryngology Head and Neck Surgery, Heilongjiang Provincial Hospital, Harbin, Heilongjiang, China. 66. Department of Otorhinolaryngology, Head and Neck Surgery, The Second Hospital of Tianjin Medical University, Tianjin, China. 67. Department of Otorhinolaryngology, Head and Neck Surgery, The Affiliated Hospital of Qinghai University, Xining, Qinghai, China. 68. Department of Otorhinolaryngology, Head and Neck Surgery, Chizhou People's Hospital, Chizhou, Anhui, China. 69. Department of Otorhinolaryngology, Head and Neck Surgery, Wuhan Third Hospital, Wuhan, Hubei, China. 70. Department of Otorhinolaryngology, Head and Neck Surgery, Gansu Provincial Hospital, Lanzhou, Gansu, China. 71. Department of Otorhinolaryngology Head and Neck Surgery, Xinjiang Military Command General Hospital, Urumqi, Xinjiang, China. 72. Department of Otorhinolaryngology, Head and Neck Surgery, Affiliated Hospital of Chifeng College, Chifeng, Inner Mongolia, China. 73. Department of Otorhinolaryngology Head and Neck Surgery, The People's Hospital of Dazu District, Chongqing, China. 74. Department of Otorhinolaryngology Head and Neck Surgery, Tianjin Union Medical Center, Tianjin, China. 75. Department of Otorhinolaryngology Head and Neck Surgery, Qinghai Red Cross Hospital, Xining, Qinghai, China. 76. Department of Otorhinolaryngology, Head and Neck Surgery, Fenyang Hospital, Shanxi Province, Fenyang, Shanxi, China.
Abstract
PURPOSE: Using the Reflux Symptom Index (RSI), this nationwide study aimed to investigate the incidence, diagnostic status, risk factors, and common symptoms of adult laryngopharyngeal reflux disease (LPRD) at otorhinolaryngology-head and neck surgery (OHNS) clinics in China. METHODS: This multicenter cross-sectional survey began at the different institutions ranged from July to October 2017, and the duration was 12 months. A total of 90,440 eligible patients were finally enrolled from 72 medical institutions in China. All these patients completed the questionnaire based on RSI. In this study, LPRD was defined as RSI > 13. RESULTS: There were 9182 with LPRD among the 90,440 eligible participants (10.15%). However, only 1294 had a history of LPRD diagnosis among those with LPRD (14.09%). There were regional differences in the frequency of LPRD (P < 0.001). The proportions of patients with LPRD in males (vs. females), middle- and old-aged patients (vs. young), with current smoking history (vs. no smoking), and current drinking history (vs. no drinking) were significantly higher (all P < 0.001). Middle and old age, current smoking, and drinking history were independent predictors of LPRD (all P < 0.001, OR 1.240, 1.261, and 1.481, respectively). "Sensations of something stuck in throat or a lump in throat", "clearing throat", and "excess throat mucus or postnasal drip" were the most frequent clinical symptoms in patients with LPRD. CONCLUSIONS: LPRD has a high incidence at the OHNS clinics in China. However, the diagnostic status of this disease is not optimistic. Older age, smoking, and drinking history were risk factors for LPRD.
PURPOSE: Using the Reflux Symptom Index (RSI), this nationwide study aimed to investigate the incidence, diagnostic status, risk factors, and common symptoms of adult laryngopharyngeal reflux disease (LPRD) at otorhinolaryngology-head and neck surgery (OHNS) clinics in China. METHODS: This multicenter cross-sectional survey began at the different institutions ranged from July to October 2017, and the duration was 12 months. A total of 90,440 eligible patients were finally enrolled from 72 medical institutions in China. All these patients completed the questionnaire based on RSI. In this study, LPRD was defined as RSI > 13. RESULTS: There were 9182 with LPRD among the 90,440 eligible participants (10.15%). However, only 1294 had a history of LPRD diagnosis among those with LPRD (14.09%). There were regional differences in the frequency of LPRD (P < 0.001). The proportions of patients with LPRD in males (vs. females), middle- and old-aged patients (vs. young), with current smoking history (vs. no smoking), and current drinking history (vs. no drinking) were significantly higher (all P < 0.001). Middle and old age, current smoking, and drinking history were independent predictors of LPRD (all P < 0.001, OR 1.240, 1.261, and 1.481, respectively). "Sensations of something stuck in throat or a lump in throat", "clearing throat", and "excess throat mucus or postnasal drip" were the most frequent clinical symptoms in patients with LPRD. CONCLUSIONS: LPRD has a high incidence at the OHNS clinics in China. However, the diagnostic status of this disease is not optimistic. Older age, smoking, and drinking history were risk factors for LPRD.