| Literature DB >> 32447980 |
Alexandre Lopes Andrade1, Mayron Alves de Vasconcelos1,2,3, Francisco Vassiliepe de Sousa Arruda1,4, Luiz Gonzaga do Nascimento Neto1,5, José Marcos da Silveira Carvalho6, Ana Claudia Silva Gondim6, Luiz Gonzaga de França Lopes6, Eduardo Henrique Silva Sousa6, Edson Holanda Teixeira1.
Abstract
The aim of this study was to investigate the antibacterial activity, antibiotic-associated synergy, and anti-biofilm activity of the ruthenium complex, cis-[RuCl2 (dppb) (bqdi)]2+ (RuNN). RuNN exhibited antimicrobial activity against Gram-positive bacteria with minimum inhibitory concentration (MIC) values ranging from 15.6 to 62.5 µg ml-1 and minimum bactericidal concentration (MBC) values ranging from 62.5 to 125 µg ml-1. A synergistic effect against Staphylococcus spp. was observed when RuNN was combined with ampicillin, and the range of associated fractional inhibitory concentration index (FICI) values was 0.187 to 0.312. A time-kill curve indicated the bactericidal activity of RuNN in the first 1-5 h. In general, RuNN inhibited biofilm formation and disrupted mature biofilms. Furthermore, RuNN altered the cellular morphology of S. aureus biofilms. Further, RuNN did not cause hemolysis of erythrocytes. The results of this study provide evidence that RuNN is a novel therapeutic candidate to treat bacterial infections caused by Staphylococcus biofilms.Entities:
Keywords: Metallodrugs; antimicrobial activity; biofilm; ruthenium; synergistic effect
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Year: 2020 PMID： 32447980 DOI： 10.1080/08927014.2020.1771317
Source DB: PubMed Journal: Biofouling ISSN： 0892-7014 Impact factor: 3.209