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Literature DB >> 3244656

Drug/polymer matrix swelling and dissolution.

R S Harland¹, A Gazzaniga, M E Sangalli, P Colombo, N A Peppas.

Abstract

The swelling and dissolution behavior of pharmaceutical systems containing a drug and a polymer can be analyzed by a mathematical model which predicts the drug released and the gel layer thickness as a function of time. It is possible to approximate the values of several of the physicochemical parameters of this model in order to obtain an order-of-magnitude analysis of the tablet dissolution process. Selected experimental results of tablet dissolution and drug release are analyzed and conclusions are made about the importance of the drug and polymer content and solubility in the release behavior.

Entities: Chemical Disease

Mesh：

Substances：

Year: 1988 PMID： 3244656 DOI： 10.1023/a:1015913207052

Source DB: PubMed Journal: Pharm Res ISSN： 0724-8741 Impact factor: 4.200

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Cited

31 in total

1. Wet granulation fine particle ethylcellulose tablets: effect of production variables and mathematical modeling of drug release.

Authors: Anjali M Agrawal; Steven H Neau; Peter L Bonate
Journal: AAPS PharmSci Date: 2003

2. Influence of Drug Properties and Formulation on In Vitro Drug Release and Biowaiver Regulation of Oral Extended Release Dosage Forms.

Authors: Zhongqiang Lin; Deliang Zhou; Stephen Hoag; Yihong Qiu
Journal: AAPS J Date: 2016-01-14 Impact factor: 4.009

3. Gastroretentive drug delivery system of ranitidine hydrochloride: formulation and in vitro evaluation.

Authors: Brijesh S Dave; Avani F Amin; Madhabhai M Patel
Journal: AAPS PharmSciTech Date: 2004-04-08 Impact factor: 3.246

4. Gauge repeatability and reproducibility for accessing variability during dissolution testing: a technical note.

Authors: Zongming Gao; Terry Moore; Anjanette P Smith; William Doub; Benjamin Westenberger; Lucinda Buhse
Journal: AAPS PharmSciTech Date: 2007-10-12 Impact factor: 3.246

5. The Properties of HPMC:PEO Extended Release Hydrophilic Matrices and their Response to Ionic Environments.

Authors: Anran Hu; Chen Chen; Michael D Mantle; Bettina Wolf; Lynn F Gladden; Ali Rajabi-Siahboomi; Shahrzad Missaghi; Laura Mason; Colin D Melia
Journal: Pharm Res Date: 2016-09-15 Impact factor: 4.200

6. Determination of continuous changes in the gel layer thickness of poly(ethylene oxide) and HPMC tablets undergoing hydration: a texture analysis study.

Authors: L Yang; B Johnson; R Fassihi
Journal: Pharm Res Date: 1998-12 Impact factor: 4.200

Drug/polymer matrix swelling and dissolution.

1. Wet granulation fine particle ethylcellulose tablets: effect of production variables and mathematical modeling of drug release.

2. Influence of Drug Properties and Formulation on In Vitro Drug Release and Biowaiver Regulation of Oral Extended Release Dosage Forms.

3. Gastroretentive drug delivery system of ranitidine hydrochloride: formulation and in vitro evaluation.

4. Gauge repeatability and reproducibility for accessing variability during dissolution testing: a technical note.

5. The Properties of HPMC:PEO Extended Release Hydrophilic Matrices and their Response to Ionic Environments.

6. Determination of continuous changes in the gel layer thickness of poly(ethylene oxide) and HPMC tablets undergoing hydration: a texture analysis study.

7. Efficacy of mucoadhesive hydrogel microparticles of whey protein and alginate for oral insulin delivery.

8. Poly(lactic-co-glycolic) acid-controlled-release systems: experimental and modeling insights.

9. Thermosensitive Pluronic hydrogel: prolonged injectable formulation for drug abuse.

10. The effect of physical aging on the dissolution rate of anionic polyelectrolytes.