BACKGROUND: An elevated serum C-reactive protein (CRP) level was observed in most patients with coronavirus disease 2019 (COVID-19). METHODS: Data for COVID-19 patients with clinical outcome in a designated hospital in Wuhan, China, were retrospectively collected and analyzed from 30 January 2020 to 20 February 2020. The prognostic value of admission CRP was evaluated in patients with COVID-19. RESULTS: Of 298 patients enrolled, 84 died and 214 recovered. Most nonsurvivors were male, older, or with chronic diseases. Compared with survivors, nonsurvivors showed significantly elevated white blood cell and neutrophil counts, neutrophil to lymphocyte ratio (NLR), systemic immune inflammation index (defined by platelet count multiplied by NLR), CRP, procalcitonin, and D-dimer and showed decreased red blood cell, lymphocyte, and platelet counts. Age, neutrophil count, platelet count, and CRP were identified as independent predictors of adverse outcome. The area under the receiver operating characteristic (ROC) curve (AUC) of CRP (0.896) was significantly higher than that of age (0.833), neutrophil count (0.820), and platelet count (0.678) in outcome prediction (all P < .05). With a cutoff value of 41.4, CRP exhibited sensitivity of 90.5%, specificity of 77.6%, positive predictive value of 61.3%, and negative predictive value of 95.4%. CRP was also an independent discriminator of severe/critical illness on admission with an AUC (0.783) comparable to age (0.828) and neutrophil count (0.729) (both P > .05). CONCLUSIONS: In patients with COVID-19, admission CRP correlated with disease severity and tended to be a good predictor of adverse outcome.
BACKGROUND: An elevated serum C-reactive protein (CRP) level was observed in most patients with coronavirus disease 2019 (COVID-19). METHODS: Data for COVID-19patients with clinical outcome in a designated hospital in Wuhan, China, were retrospectively collected and analyzed from 30 January 2020 to 20 February 2020. The prognostic value of admission CRP was evaluated in patients with COVID-19. RESULTS: Of 298 patients enrolled, 84 died and 214 recovered. Most nonsurvivors were male, older, or with chronic diseases. Compared with survivors, nonsurvivors showed significantly elevated white blood cell and neutrophil counts, neutrophil to lymphocyte ratio (NLR), systemic immune inflammation index (defined by platelet count multiplied by NLR), CRP, procalcitonin, and D-dimer and showed decreased red blood cell, lymphocyte, and platelet counts. Age, neutrophil count, platelet count, and CRP were identified as independent predictors of adverse outcome. The area under the receiver operating characteristic (ROC) curve (AUC) of CRP (0.896) was significantly higher than that of age (0.833), neutrophil count (0.820), and platelet count (0.678) in outcome prediction (all P < .05). With a cutoff value of 41.4, CRP exhibited sensitivity of 90.5%, specificity of 77.6%, positive predictive value of 61.3%, and negative predictive value of 95.4%. CRP was also an independent discriminator of severe/critical illness on admission with an AUC (0.783) comparable to age (0.828) and neutrophil count (0.729) (both P > .05). CONCLUSIONS: In patients with COVID-19, admission CRP correlated with disease severity and tended to be a good predictor of adverse outcome.
Authors: Clark D Russell; Cameron J Fairfield; Thomas M Drake; Lance Turtle; R Andrew Seaton; Dan G Wootton; Louise Sigfrid; Ewen M Harrison; Annemarie B Docherty; Thushan I de Silva; Conor Egan; Riinu Pius; Hayley E Hardwick; Laura Merson; Michelle Girvan; Jake Dunning; Jonathan S Nguyen-Van-Tam; Peter J M Openshaw; J Kenneth Baillie; Malcolm G Semple; Antonia Ho Journal: Lancet Microbe Date: 2021-06-02
Authors: Neil Powell; Philip Howard; Martin J Llewelyn; Tamas Szakmany; Mahableswhar Albur; Stuart E Bond; Joanne Euden; Lucy Brookes-Howell; Paul Dark; Thomas P Hellyer; Susan Hopkins; Iain J McCullagh; Margaret Ogden; Philip Pallmann; Helena Parsons; David G Partridge; Dominick E Shaw; Bethany Shinkins; Stacy Todd; Emma Thomas-Jones; Robert West; Enitan D Carrol; Jonathan A T Sandoe Journal: Antibiotics (Basel) Date: 2021-05-01
Authors: Wadah Ibrahim; Rebecca L Cordell; Michael J Wilde; Matthew Richardson; Liesl Carr; Ananga Sundari Devi Dasi; Beverley Hargadon; Robert C Free; Paul S Monks; Christopher E Brightling; Neil J Greening; Salman Siddiqui Journal: ERJ Open Res Date: 2021-07-05