Literature DB >> 32445474

Impact of Intrapartum Oral Azithromycin on the Acquired Macrolide Resistome of Infants' Nasopharynx: A Randomized Controlled Trial.

Abdoulie Bojang1, Sarah L Baines2, Bully Camara1, Romain Guerillot2, Liam Donovan2, Raquel Sánchez Marqués1, Ousman Secka1, Umberto D'Alessandro1, Christian Bottomley3, Benjamin P Howden2,4, Anna Roca1.   

Abstract

In a post hoc analysis of samples from an intrapartum azithromycin randomized clinical trial, we found that children whose mothers had been treated with the drug had higher prevalence of macrolide-resistance genes msr(A) and ermC at 28 days but not at 12 months. The 2 genes were positively associated in the nasopharynx. CLINICAL TRIALS REGISTRATION: NCT1800942.
© The Author(s) 2020. Published by Oxford University Press for the Infectious Diseases Society of America.

Entities:  

Keywords:  zzm321990 ermC; zzm321990 msr(A)zzm321990 ; azithromycin; NPS; The Gambia

Year:  2020        PMID： 32445474      PMCID： PMC7819521          DOI： 10.1093/cid/ciaa609

Source DB:  PubMed          Journal:  Clin Infect Dis        ISSN： 1058-4838            Impact factor:   9.079


  18 in total

Review 1.  Transfer of antibiotic-resistance genes via phage-related mobile elements.

Authors:  Maryury Brown-Jaque; William Calero-Cáceres; Maite Muniesa
Journal:  Plasmid       Date:  2015-01-15       Impact factor: 3.466

Review 2.  Mechanisms of resistance to macrolides and lincosamides: nature of the resistance elements and their clinical implications.

Authors:  Roland Leclercq
Journal:  Clin Infect Dis       Date:  2002-01-11       Impact factor: 9.079

3.  Short-term increase in prevalence of nasopharyngeal carriage of macrolide-resistant Staphylococcus aureus following mass drug administration with azithromycin for trachoma control.

Authors:  Ebrima Bojang; James Jafali; Vincent Perreten; John Hart; Emma M Harding-Esch; Ansumana Sillah; David C W Mabey; Martin J Holland; Robin L Bailey; Anna Roca; Sarah E Burr
Journal:  BMC Microbiol       Date:  2017-03-28       Impact factor: 3.605

4.  Microsatellite instability testing in colorectal cancer using the QiaXcel advanced platform.

Authors:  Isabel Förster; Michael Brockmann; Oliver Schildgen; Verena Schildgen
Journal:  BMC Cancer       Date:  2018-04-27       Impact factor: 4.430

5.  Impact of Long-Term Erythromycin Therapy on the Oropharyngeal Microbiome and Resistance Gene Reservoir in Non-Cystic Fibrosis Bronchiectasis.

Authors:  Jocelyn M Choo; Guy C J Abell; Rachel Thomson; Lucy Morgan; Grant Waterer; David L Gordon; Steven L Taylor; Lex E X Leong; Steve L Wesselingh; Lucy D Burr; Geraint B Rogers
Journal:  mSphere       Date:  2018-04-18       Impact factor: 4.389

6.  Prevention of bacterial infections in the newborn by pre-delivery administration of azithromycin: Study protocol of a randomized efficacy trial.

Authors:  Anna Roca; Claire Oluwalana; Bully Camara; Abdoulie Bojang; Sarah Burr; Timothy M E Davis; Robin Bailey; Beate Kampmann; Jenny Mueller; Christian Bottomley; Umberto D'Alessandro
Journal:  BMC Pregnancy Childbirth       Date:  2015-11-19       Impact factor: 3.007

7.  The prevalence of genotypes that determine resistance to macrolides, lincosamides, and streptogramins B compared with spiramycin susceptibility among erythromycin-resistant Staphylococcus epidermidis.

Authors:  Marek Juda; Beata Chudzik-Rzad; Anna Malm
Journal:  Mem Inst Oswaldo Cruz       Date:  2016-03       Impact factor: 2.743

8.  Oral azithromycin given during labour decreases bacterial carriage in the mothers and their offspring: a double-blind randomized trial.

Authors:  A Roca; C Oluwalana; A Bojang; B Camara; B Kampmann; R Bailey; A Demba; C Bottomley; U D'Alessandro
Journal:  Clin Microbiol Infect       Date:  2016-03-26       Impact factor: 8.067

9.  Azithromycin to Reduce Childhood Mortality in Sub-Saharan Africa.

Authors:  Jeremy D Keenan; Robin L Bailey; Sheila K West; Ahmed M Arzika; John Hart; Jerusha Weaver; Khumbo Kalua; Zakayo Mrango; Kathryn J Ray; Catherine Cook; Elodie Lebas; Kieran S O'Brien; Paul M Emerson; Travis C Porco; Thomas M Lietman
Journal:  N Engl J Med       Date:  2018-04-26       Impact factor: 91.245

10.  Long-term Impact of Oral Azithromycin Taken by Gambian Women During Labor on Prevalence and Antibiotic Susceptibility of Streptococcus pneumoniae and Staphylococcus aureus in Their Infants: Follow-up of a Randomized Clinical Trial.

Authors:  Abdoulie Bojang; Bully Camara; Isatou Jagne Cox; Claire Oluwalana; Kodou Lette; Effua Usuf; Christian Bottomley; Benjamin P Howden; Umberto D'Alessandro; Anna Roca
Journal:  Clin Infect Dis       Date:  2018-09-28       Impact factor: 9.079
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  1 in total

1.  Gut Resistome after Antibiotics among Children with Uncomplicated Severe Acute Malnutrition: A Randomized Controlled Trial.

Authors:  Catherine E Oldenburg; Armin Hinterwirth; Millogo Ourohiré; Clarisse Dah; Moussa Ouédraogo; Ali Sié; Valentin Boudo; Cindi Chen; Kevin Ruder; Lina Zhong; Elodie Lebas; Fanice Nyatigo; Benjamin F Arnold; Kieran S O'Brien; Thuy Doan
Journal:  Am J Trop Med Hyg       Date:  2022-06-13       Impact factor: 3.707
  1 in total

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