Literature DB >> 32445447

BPC 157 Rescued NSAID-cytotoxicity Via Stabilizing Intestinal Permeability and Enhancing Cytoprotection.

Jong M Park1, Ho J Lee2, Predrag Sikiric3, Ki B Hahm4,5.   

Abstract

The stable gastric pentadecapeptide BPC 157 protects stomach cells, maintains gastric integrity against various noxious agents such as alcohol, nonsteroidal anti-inflammatory drugs (NSAIDs), and exerts cytoprotection/ adaptive cytoprotection/organoprotection in other epithelia, that is, skin, liver, pancreas, heart, and brain. Especially BPC 157 counteracts gastric endothelial injury that precedes and induces damage to the gastric epithelium and generalizes "gastric endothelial protection" to protection of the endothelium of other vessels including thrombosis, prolonged bleeding, and thrombocytopenia. In this background, we put the importance of BPC 157 as a possible way of securing GI safety against NSAIDs-induced gastroenteropathy since still unmet medical needs to mitigate NSAIDs-induced cytotoxicity are urgent. Furthermore, gastrointestinal irritants such as physical or mental stress, NSAIDs administration, surfactants destroyer such as bile acids, alcohol can lead to leaky gut syndrome through increasing epithelial permeability. In this review article, we described the potential rescuing actions of BPC 157 against leaky gut syndrome after NSAIDs administration for the first time. Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.net.

Entities:  

Keywords:  BPC 157; NSAID induced gastroenteropathy; bile acids; epithelial permeability; gut permeability; leaky gut syndrome

Mesh：

Substances：

Year:  2020        PMID： 32445447     DOI： 10.2174/1381612826666200523180301

Source DB:  PubMed          Journal:  Curr Pharm Des        ISSN： 1381-6128            Impact factor:   3.116


  12 in total

1.  Therapy Effect of the Stable Gastric Pentadecapeptide BPC 157 on Acute Pancreatitis as Vascular Failure-Induced Severe Peripheral and Central Syndrome in Rats.

Authors:  Ivan Maria Smoday; Igor Petrovic; Luka Kalogjera; Hrvoje Vranes; Helena Zizek; Ivan Krezic; Slaven Gojkovic; Ivan Skorak; Klaudija Hriberski; Ivan Brizic; Milovan Kubat; Sanja Strbe; Ivan Barisic; Marija Sola; Eva Lovric; Marin Lozic; Alenka Boban Blagaic; Anita Skrtic; Sven Seiwerth; Predrag Sikiric
Journal:  Biomedicines       Date:  2022-06-01

2.  Novel Therapeutic Effects in Rat Spinal Cord Injuries: Recovery of the Definitive and Early Spinal Cord Injury by the Administration of Pentadecapeptide BPC 157 Therapy.

Authors:  Darko Perovic; Marija Milavic; Stjepan Dokuzovic; Ivan Krezic; Slaven Gojkovic; Hrvoje Vranes; Igor Bebek; Vide Bilic; Nenad Somun; Ivan Brizic; Ivan Skorak; Klaudija Hriberski; Suncana Sikiric; Eva Lovric; Sanja Strbe; Milovan Kubat; Alenka Boban Blagaic; Anita Skrtic; Sven Seiwerth; Predrag Sikiric
Journal:  Curr Issues Mol Biol       Date:  2022-04-27       Impact factor: 2.976

3.  Bowel adhesion and therapy with the stable gastric pentadecapeptide BPC 157, L-NAME and L-arginine in rats.

Authors:  Lidija Berkopic Cesar; Slaven Gojkovic; Ivan Krezic; Dominik Malekinusic; Helena Zizek; Lovorka Batelja Vuletic; Andreja Petrovic; Katarina Horvat Pavlov; Domagoj Drmic; Antonio Kokot; Josipa Vlainic; Sven Seiwerth; Predrag Sikiric
Journal:  World J Gastrointest Pharmacol Ther       Date:  2020-11-08

4.  Cytoprotective gastric pentadecapeptide BPC 157 resolves major vessel occlusion disturbances, ischemia-reperfusion injury following Pringle maneuver, and Budd-Chiari syndrome.

Authors:  Predrag Sikiric; Anita Skrtic; Slaven Gojkovic; Ivan Krezic; Helena Zizek; Eva Lovric; Suncana Sikiric; Mario Knezevic; Sanja Strbe; Marija Milavic; Antonio Kokot; Alenka Boban Blagaic; Sven Seiwerth
Journal:  World J Gastroenterol       Date:  2022-01-07       Impact factor: 5.742

5.  Stable Gastric Pentadecapeptide BPC 157 Therapy for Primary Abdominal Compartment Syndrome in Rats.

Authors:  Marijan Tepes; Slaven Gojkovic; Ivan Krezic; Helena Zizek; Hrvoje Vranes; Zrinko Madzar; Goran Santak; Lovorka Batelja; Marija Milavic; Suncana Sikiric; Ivica Kocman; Karol Simonji; Mariam Samara; Mario Knezevic; Ivan Barisic; Eva Lovric; Sanja Strbe; Antonio Kokot; Ivica Sjekavica; Toni Kolak; Anita Skrtic; Sven Seiwerth; Alenka Boban Blagaic; Predrag Sikiric
Journal:  Front Pharmacol       Date:  2021-12-13       Impact factor: 5.810

Review 6.  Stable Gastric Pentadecapeptide BPC 157 and Wound Healing.

Authors:  Sven Seiwerth; Marija Milavic; Jaksa Vukojevic; Slaven Gojkovic; Ivan Krezic; Lovorka Batelja Vuletic; Katarina Horvat Pavlov; Andrea Petrovic; Suncana Sikiric; Hrvoje Vranes; Andreja Prtoric; Helena Zizek; Tajana Durasin; Ivan Dobric; Mario Staresinic; Sanja Strbe; Mario Knezevic; Marija Sola; Antonio Kokot; Marko Sever; Eva Lovric; Anita Skrtic; Alenka Boban Blagaic; Predrag Sikiric
Journal:  Front Pharmacol       Date:  2021-06-29       Impact factor: 5.810

7.  BPC 157 as a Therapy for Retinal Ischemia Induced by Retrobulbar Application of L-NAME in Rats.

Authors:  Mirna Zlatar; Antonio Kokot; Lovorka Batelja Vuletic; Sanja Masnec; Tamara Kralj; Marija Milkovic Perisa; Ivan Barisic; Bozo Radic; Kristina Milanovic; Domagoj Drmic; Sven Seiwerth; Predrag Sikiric
Journal:  Front Pharmacol       Date:  2021-06-10       Impact factor: 5.810

8.  Occlusion of the Superior Mesenteric Artery in Rats Reversed by Collateral Pathways Activation: Gastric Pentadecapeptide BPC 157 Therapy Counteracts Multiple Organ Dysfunction Syndrome; Intracranial, Portal, and Caval Hypertension; and Aortal Hypotension.

Authors:  Mario Knezevic; Slaven Gojkovic; Ivan Krezic; Helena Zizek; Dominik Malekinusic; Borna Vrdoljak; Hrvoje Vranes; Tamara Knezevic; Ivan Barisic; Katarina Horvat Pavlov; Domagoj Drmic; Miro Staroveski; Antonija Djuzel; Zoran Rajkovic; Toni Kolak; Ivica Kocman; Eva Lovric; Marija Milavic; Suncana Sikiric; Ante Tvrdeic; Leonardo Patrlj; Sanja Strbe; Antonio Kokot; Alenka Boban Blagaic; Anita Skrtic; Sven Seiwerth; Predrag Sikiric
Journal:  Biomedicines       Date:  2021-05-26

9.  BPC 157 Therapy and the Permanent Occlusion of the Superior Sagittal Sinus in Rat: Vascular Recruitment.

Authors:  Slaven Gojkovic; Ivan Krezic; Hrvoje Vranes; Helena Zizek; Domagoj Drmic; Katarina Horvat Pavlov; Andrea Petrovic; Lovorka Batelja Vuletic; Marija Milavic; Suncana Sikiric; Irma Stilinovic; Mariam Samara; Mario Knezevic; Ivan Barisic; Ivica Sjekavica; Eva Lovric; Anita Skrtic; Sven Seiwerth; Predrag Sikiric
Journal:  Biomedicines       Date:  2021-06-28

10.  Stable Gastric Pentadecapeptide BPC 157 Therapy of Rat Glaucoma.

Authors:  Tamara Kralj; Antonio Kokot; Mirna Zlatar; Sanja Masnec; Katarina Kasnik Kovac; Marija Milkovic Perisa; Lovorka Batelja Vuletic; Ana Giljanovic; Sanja Strbe; Suncana Sikiric; Slaven Balog; Bojan Sontacchi; Dijana Sontacchi; Matko Buljan; Eva Lovric; Alenka Boban Blagaic; Anita Skrtic; Sven Seiwerth; Predrag Sikiric
Journal:  Biomedicines       Date:  2021-12-31
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