Charles R Bauer1, John Langer2, Brittany Lambert-Brown3, Seetha Shankaran4, Henrietta S Bada5, Barry Lester6, Lynn L Lagasse6, Toni Whitaker7, Jane Hammond2. 1. Department of Pediatrics, Miller School of Medicine, University of Miami, Miami, FL, 33136, USA. cbauer@med.miami.edu. 2. Statistics and Epidemiology, RTI International, Research Triangle Park, NC, 27709, USA. 3. Department of Pediatrics, Miller School of Medicine, University of Miami, Miami, FL, 33136, USA. 4. Department of Pediatrics, Wayne State University School of Medicine, Detroit, MI, 48201, USA. 5. Department of Pediatrics, University of Kentucky Hospital, Lexington, KY, 40506, USA. 6. Department of Pediatrics Brown Center for the Study of Children at Risk, Warren Alpert Medical School of Brown University, Women and Infants Hospital of Rhode Island, Providence, RI, 02903, USA. 7. Boling Center for Developmental Disabilities, University of Tennessee Health Science Center, Memphis, TN, 38105, USA.
Abstract
OBJECTIVE: This study examined acute findings and long-term outcome trajectories between birth and adolescence in children with prenatal opiate exposure. STUDY DESIGN: Ninety children (45 opiate-exposed, 45 non-exposed) completed assessments between 1 month and 15 years of age. Outcome variables (medical, anthropomorphic, developmental, and behavioral) were analyzed at individual time points and using longitudinal statistical modeling. RESULTS: Opiate-exposed infants displayed transient neurologic findings, but no substantial signs or symptoms long term. There were no group differences in growth, cognitive functioning, or behavior at individual time periods; however, the trajectories of outcomes using longitudinal analyses adjusting for variables known to impact outcome demonstrated increased deficits among opiate-exposed children over time with regards to weight, head circumference, cognitive functioning, and behavior. CONCLUSIONS: Findings support concerns that maternal opiate use during pregnancy may negatively impact a child's developmental trajectory, which in turn may impose concerns to society (e.g., increased need for social, medical, and/or educational services).
OBJECTIVE: This study examined acute findings and long-term outcome trajectories between birth and adolescence in children with prenatal opiate exposure. STUDY DESIGN: Ninety children (45 opiate-exposed, 45 non-exposed) completed assessments between 1 month and 15 years of age. Outcome variables (medical, anthropomorphic, developmental, and behavioral) were analyzed at individual time points and using longitudinal statistical modeling. RESULTS: Opiate-exposed infants displayed transient neurologic findings, but no substantial signs or symptoms long term. There were no group differences in growth, cognitive functioning, or behavior at individual time periods; however, the trajectories of outcomes using longitudinal analyses adjusting for variables known to impact outcome demonstrated increased deficits among opiate-exposed children over time with regards to weight, head circumference, cognitive functioning, and behavior. CONCLUSIONS: Findings support concerns that maternal opiate use during pregnancy may negatively impact a child's developmental trajectory, which in turn may impose concerns to society (e.g., increased need for social, medical, and/or educational services).
Authors: Nicole L G Villapiano; Tyler N A Winkelman; Katy B Kozhimannil; Matthew M Davis; Stephen W Patrick Journal: JAMA Pediatr Date: 2017-02-01 Impact factor: 16.193
Authors: Kathryn L Hamilton; Andrew C Harris; Jonathan C Gewirtz; Sheldon B Sparber; Lisa M Schrott Journal: Neurotoxicol Teratol Date: 2005 Jan-Feb Impact factor: 3.763
Authors: Seetha Shankaran; Barry M Lester; Abhik Das; Charles R Bauer; Henrietta S Bada; Linda Lagasse; Rosemary Higgins Journal: Semin Fetal Neonatal Med Date: 2007-02-20 Impact factor: 3.926
Authors: L L LaGasse; D Messinger; B M Lester; R Seifer; E Z Tronick; C R Bauer; S Shankaran; H S Bada; L L Wright; V L Smeriglio; L P Finnegan; P L Maza; J Liu Journal: Arch Dis Child Fetal Neonatal Ed Date: 2003-09 Impact factor: 5.747
Authors: H S Bada; C R Bauer; S Shankaran; B Lester; L L Wright; A Das; K Poole; V L Smeriglio; L P Finnegan; P L Maza Journal: Arch Dis Child Fetal Neonatal Ed Date: 2002-09 Impact factor: 5.747