Daniel J van Wamelen1,2,3, Raquel N Taddei1,2, Alexander Calvano1,2, Nataliya Titova4,5,6, Valentina Leta1,2, Igor Shtuchniy4, Peter Jenner5,6, Pablo Martinez-Martin7, Elena Katunina4, K Ray Chaudhuri1,2. 1. King's College London, Department of Neurosciences, Institute of Psychiatry, Psychology & Neuroscience, De Crespigny Park, London, United Kingdom. 2. Parkinson Foundation Centre of Excellence, King's College Hospital, Denmark Hill, London, United Kingdom. 3. Radboud University Medical Centre, Donders Institute for Brain, Cognition and Behaviour, Department of Neurology, Nijmegen, the Netherlands. 4. Federal State Autonomous Educational Institution of Higher Education «N.I. Pirogov Russian National Research Medical University» of the Ministry of Health of the Russian Federation, Department of Neurology, Neurosurgery and Medical Genetics, Moscow, Russia. 5. Federal State Budgetary Institution «Federal center of brain and neurotechnologies» of the Ministry of Health of the Russian Federation, Department of Neurodegenerative Diseases, Moscow, Russia. 6. King's College London, Institute of Pharmaceutical Science, Hodgkin Building, Guy's Campus, London, United Kingdom. 7. Center for Networked Biomedical Research in Neurodegenerative Diseases (CIBERNED), Carlos III Institute of Health, Madrid, Spain.
Abstract
BACKGROUND: Previous studies have identified low serum uric acid (SUA) levels as a risk factor for the development of Parkinson's disease (PD). Prodromal PD mainly manifests as a complex of non-motor features, but the association between SUA levels and nonmotor symptoms (NMS) burden level in advanced PD patients is poorly studied. OBJECTIVE: To determine the association between SUA levels and NMS in PD patients. METHODS: Data were gathered from an open label, cross sectional, study with analysis of SUA levels in 87 PD patients and were correlated to NMS through the NMS scale (NMSS). In addition, we examined the possible relation between SUA and NMS burden levels and motor scores. RESULTS: There was a moderate negative association between SUA levels and NMSS total score (ρ= -0.379, p < 0.001). In line with this, we observed that higher NMS burden was associated with lower SUA levels (p < 0.001). Within individual NMSS domains, a moderate negative correlation was observed between SUA levels and the cardiovascular/falls (ρ= -0.285, p = 0.008), sleep/fatigue (ρ= -0.299, p = 0.005), and miscellaneous domains (ρ= -0.318, p = 0.003). CONCLUSION: In this observational study we observed that SUA levels were negatively associated to NMS burden in PD patients with a specific link to miscellaneous, sleep/fatigue and cardiovascular domains of the NMSS. Interestingly, we did not find a clear relation between SUA and motor scores. Future large-scale prospective studies in de novo and advanced PD are needed to evaluate and establish these associations.
BACKGROUND: Previous studies have identified low serum uric acid (SUA) levels as a risk factor for the development of Parkinson's disease (PD). Prodromal PD mainly manifests as a complex of non-motor features, but the association between SUA levels and nonmotor symptoms (NMS) burden level in advanced PDpatients is poorly studied. OBJECTIVE: To determine the association between SUA levels and NMS in PDpatients. METHODS: Data were gathered from an open label, cross sectional, study with analysis of SUA levels in 87 PDpatients and were correlated to NMS through the NMS scale (NMSS). In addition, we examined the possible relation between SUA and NMS burden levels and motor scores. RESULTS: There was a moderate negative association between SUA levels and NMSS total score (ρ= -0.379, p < 0.001). In line with this, we observed that higher NMS burden was associated with lower SUA levels (p < 0.001). Within individual NMSS domains, a moderate negative correlation was observed between SUA levels and the cardiovascular/falls (ρ= -0.285, p = 0.008), sleep/fatigue (ρ= -0.299, p = 0.005), and miscellaneous domains (ρ= -0.318, p = 0.003). CONCLUSION: In this observational study we observed that SUA levels were negatively associated to NMS burden in PDpatients with a specific link to miscellaneous, sleep/fatigue and cardiovascular domains of the NMSS. Interestingly, we did not find a clear relation between SUA and motor scores. Future large-scale prospective studies in de novo and advanced PD are needed to evaluate and establish these associations.
Authors: Huan Yu; Kexiang Shi; Haiming Yang; Dianjianyi Sun; Jun Lv; Yuan Ma; Sailimai Man; Jianchun Yin; Bo Wang; Canqing Yu; Liming Li Journal: Int J Environ Res Public Health Date: 2022-07-01 Impact factor: 4.614
Authors: Artur Schumacher-Schuh; Andrei Bieger; Wyllians V Borelli; Makayla K Portley; Paula Saffie Awad; Sara Bandres-Ciga Journal: Front Neurol Date: 2022-01-31 Impact factor: 4.003
Authors: Daniele Urso; Daniel J van Wamelen; Lucia Batzu; Valentina Leta; Juliet Staunton; José A Pineda-Pardo; Giancarlo Logroscino; Jagdish Sharma; K Ray Chaudhuri Journal: NPJ Parkinsons Dis Date: 2022-08-02