Sheila Weinmann1, Stephanie A Irving2, Padma Koppolu2, Allison L Naleway2, Edward A Belongia3, Simon J Hambidge4, Michael L Jackson5, Nicola P Klein6, Bruno Lewin7, Elizabeth Liles2, Mona Marin8, Ning Smith2, Eric Weintraub8, Colleen Chun2. 1. Center for Health Research, Kaiser Permanente Northwest, 3800 North Interstate Avenue, Portland, OR 97227, USA. Electronic address: Sheila.Weinmann@kpchr.org. 2. Center for Health Research, Kaiser Permanente Northwest, 3800 North Interstate Avenue, Portland, OR 97227, USA. 3. Center for Clinical Epidemiology and Population Health, Marshfield Clinic Research Institute, 1000 North Oak Avenue (ML2), Marshfield, WI 54449, USA. 4. Denver Community Health Services, Denver Health, Mailcode 0278, 777 Bannock Street, Denver, CO 80204, USA; Institute for Health Research, Kaiser Permanente Colorado, 2550 South Parker Road, Suite 200, Denver, CO 80014, USA. 5. Kaiser Permanente Washington Health Research Institute, 1730 Minor Avenue, Suite 1600, Seattle, WA 98101, USA. 6. Vaccine Study Center, Division of Research, Northern California Kaiser Permanente, 1 Kaiser Plaza, 16th Floor, Oakland, CA 94612, USA. 7. Department of Research and Evaluation, Southern California Kaiser Permanente, 100 S Los Robles Avenue, Second Floor, Pasadena, CA 91101, USA. 8. Centers for Disease Control and Prevention, 1600 Clifton Road NE, MS V18-4, Atlanta, GA 30333, USA.
Abstract
INTRODUCTION: Children may receive measles-mumps-rubella (MMR) and varicella (VAR) vaccines separately or as measles-mumps-rubella-varicella (MMRV). We examined whether pediatric herpes zoster (HZ) incidence varied by pattern of varicella vaccine administration. METHODS: In six integrated health systems, we examined HZ incidence among children turning 12 months old during 2003-2008. All received varicella and MMR vaccines on recommended schedules. Cases were identified through 2014 using ICD-9 codes. Incidence was examined by number of varicella vaccine doses and same-day MMR. RESULTS: Among 199,797 children, overall HZ incidence was 18.6/100,000 person-years in the first-dose MMR + VAR group, 17.9/100,000 person-years in the MMRV group, and 7.5/100,000 person-years in the VAR-alone group. HZ incidence was lower following the second dose than before the second dose in all first-dose groups. CONCLUSIONS: HZ incidence was not meaningfully different between the MMRV and MMR + VAR first-dose groups. Overall and within first-dose groups, HZ incidence was lower among children receiving two varicella vaccine doses.
INTRODUCTION: Children may receive measles-mumps-rubella (MMR) and varicella (VAR) vaccines separately or as measles-mumps-rubella-varicella (MMRV). We examined whether pediatric herpes zoster (HZ) incidence varied by pattern of varicella vaccine administration. METHODS: In six integrated health systems, we examined HZ incidence among children turning 12 months old during 2003-2008. All received varicella and MMR vaccines on recommended schedules. Cases were identified through 2014 using ICD-9 codes. Incidence was examined by number of varicella vaccine doses and same-day MMR. RESULTS: Among 199,797 children, overall HZ incidence was 18.6/100,000 person-years in the first-dose MMR + VAR group, 17.9/100,000 person-years in the MMRV group, and 7.5/100,000 person-years in the VAR-alone group. HZ incidence was lower following the second dose than before the second dose in all first-dose groups. CONCLUSIONS: HZ incidence was not meaningfully different between the MMRV and MMR + VAR first-dose groups. Overall and within first-dose groups, HZ incidence was lower among children receiving two varicella vaccine doses.
Authors: Ellen Rafferty; Laura Reifferscheid; Margaret L Russell; Stephanie Booth; Lawrence W Svenson; Shannon E MacDonald Journal: Eur J Clin Microbiol Infect Dis Date: 2021-06-26 Impact factor: 3.267