| Literature DB >> 3244204 |
S Mizusawa1, Y Kondoh, M Murakami, H Nakamichi, H Sasaki, K Komatsu, A Takahashi, Y Kudoh, K Watanabe, Y Ono.
Abstract
The effect of methotrexate (MTX) on local cerebral blood flow (I-CBF) was studied with autoradiographic [14C]-iodoantipyrine methods in normal conscious rats. I-CBF was reduced by 30-57% in the rats given MTX (100 mg or 200 mg/body) as compared to that in the saline injected control group, but no dose-dependent effect was observed. The mechanism of I-CBF reduction by MTX was discussed.Entities:
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Year: 1988 PMID： 3244204 DOI： 10.1254/jjp.48.499
Source DB: PubMed Journal: Jpn J Pharmacol ISSN： 0021-5198