Cardio-oncology services during the COVID-19 pandemic: practical considerations and challenges.

Cardiovascular (CV) disease is particularly prevalent among patients with severe coronavirus disease 2019 (COVID‐19) and confers a fivefold higher risk of mortality. Cancer is further associated with a 3.5‐fold higher risk of major events including death or need for mechanical ventilation or intensive care unit admission in patients with COVID‐19 and this risk is higher in patients having undergone chemotherapy or surgery in the past month (75% vs. 43%).

Cardio‐oncology represents the intersection of the two entities, CV disease and cancer, and although epidemiological evidence is still missing, it is expected that it deals with patients with a high propensity and/or severity of COVID‐19. This is particularly true for patients receiving treatment for active cancer, those experiencing cardiotoxicity from anticancer therapy or those with immunosuppression due to haematological malignancies, specific anticancer therapies or stem cell transplantation. In addition to the risk of COVID‐19 infection, cardio‐oncology patients may also be deprived of medical services by not getting to the hospital or not receiving the indicated care once there, because of the quarantine measures and the inevitable reallocation of medical resources. As a result, there are several challenges that the cardio‐oncology service needs to address during the COVID‐19 pandemic in terms of required adaptations in clinical practice and management of patients with suspected or confirmed COVID‐19.

Exposure of cancer patients or survivors to potential COVID‐19 cases should be minimized, in accordance with the social distancing measures imposed in many countries, without compromising at the same time the role of cardio‐oncology consultation in patients' outcomes. The risk of exposure to COVID‐19 is higher in medical facilities, particularly referral hospitals, so an important measure would be to secure a separate and protected access to oncology, haematology and cardio‐oncology departments and clinics. For the public spaces and other departments that may be used by cancer patients like the radiology department, all the general prophylactic measures should be applied.

Cardiotoxicity risk stratification before the initiation of anticancer therapy is now more crucial than ever. To minimize the risk of exposure, baseline cardiological evaluation can be omitted in patients with low or very low cardiotoxicity risk, including those with no history of CV disease, CV risk factors, previous cardiotoxicity or previous cardiotoxic therapies and those not being scheduled for anticancer regimens with established cardiotoxicity profile (Table ). In contrast, medium and high‐risk patients should be assessed according to current guidelines and local practices. During cancer therapy, the regular CV follow‐up of patients should be modified in a way that mitigates the risk of not identifying and treating cardiotoxicity on time while attenuating the potential exposure to COVID‐19. Biomarkers, including cardiac troponins (cTn) and natriuretic peptides (NP), have proven their role in early identification of cardiotoxicity in the form of myocardial dysfunction and can replace follow‐up echocardiographic studies in asymptomatic patients during this period. These biomarkers can be assessed during scheduled cancer therapy, without the need for additional hospital visits as in the case of imaging. It should be stressed though that cardiotoxicity is not only about myocardial dysfunction and biomarkers are not always available and cannot identify other toxicities.

Table 1

Proposed adaptations in cardio‐oncology services during the COVID‐19 pandemic

Baseline assessment before cancer therapy	Omit in patients with low or very low risk of cardiotoxicity including those without: – history of cardiovascular disease – two or more cardiovascular risk factors – history of cardiotoxicity – history of previous cardiotoxic therapy – scheduled anticancer regimens with established cardiotoxicity profile Maintain in patients with moderate or high cardiotoxicity risk
Follow‐up during cancer therapy	Defer in the absence of symptoms or signs of cardiovascular complications Consider replacement of cardiac imaging by biomarkers (cardiac troponin, with or without natriuretic peptides) in patients with moderate or high cardiotoxicity risk, including those with: – history of cardiovascular disease – multiple cardiovascular risk factors – history of cardiotoxicity – particularly cardiotoxic anticancer regimens Establish a teleconsultation system to be used by patients with non‐emergent symptoms before arrangement of clinic visit
Routine follow‐up of cancer survivors	Defer in asymptomatic survivors Establish a teleconsultation system to be used by patients with non‐emergent symptoms before arrangement of clinic visit
Diagnostic modalities	Defer non‐crucial cardiac imaging sessions Consider replacement of imaging by cardiac biomarkers Consider replacement of conventional echocardiography by focused echocardiography Apply all relevant protection measures during cardiac imaging
Tele‐health and information	Establish: – a patient teleconsultation system through telephone, web‐based applications, mobile applications or other communication means – an emergency telephone number – a telecommunication platform for multidisciplinary physician meetings – a patient information system with regular updates through dedicated webpages or other resources

Imaging and mainly echocardiography is a pillar of cardio‐oncology, but its reasonable and modified use will minimize the exposure of patients and physicians. Apart from the careful selection of patients who need imaging on the basis of a result that will impact on therapy or outcome, point of care or focused echocardiographic protocols for cardio‐oncology may be used to address specific clinical questions while minimizing the examination time , , ; further precautions are needed concerning the disinfection of probes and devices. Alternative imaging modalities (e.g. multi‐gated acquisition scans) can be suggested to minimize patient and physician or sonographer exposure. Specific instructions and measures have been published recently for the application of all imaging modalities, including echocardiography, cardiac computed tomography, magnetic resonance and nuclear imaging techniques, during this outbreak. , ,

Follow‐up appointments for cancer survivors should be deferred, prioritizing patients' safety and allocating appropriately the existing health care resources. Cancer patients under treatment and cancer survivors should be well informed and updated through all available resources and maintain contact with the cardio‐oncology team through telephone calls, mobile applications and smart digital web‐based applications. Telecommunication‐based consultation between physicians and patients and among physicians can help to continue many of the cardio‐oncology service functions to promote safe delivery of cancer care without disruption while limiting the patients' exposure.

Cardiovascular complications of COVID‐19 include myocardial injury, acute myocardial infarction, heart failure, fulminant myocarditis, takotsubo syndrome, arrhythmias, conduction disturbances, cardiogenic shock and venous thromboembolism. In a cancer patient, these events can also represent CV toxicity of anticancer treatments, thus creating important diagnostic and therapeutic dilemmas. Acute cardiac injury, presenting as cTn or NP elevation, is the most commonly reported COVID‐19‐related CV complication, with an incidence of 8–12% in the general population. Although an advisory by the American College of Cardiology discourages random measurement of cardiac biomarkers, this cannot be applied in many cancer patients, in whom these biomarkers can be used for cardiotoxicity surveillance, attenuating the need for echocardiography or other imaging modalities. cTn elevation, electrocardiographic and echocardiographic abnormalities in the setting of COVID‐19 are further indicative of disease severity and prognostic markers of adverse outcomes. In addition, a cytokine release syndrome represents a manifestation of advanced COVID‐19, while it may also be a complication of anticancer therapy and particularly of chimeric antigen receptor T‐cell agents used in chemotherapy‐refractory haematological and other malignancies. A comprehensive assessment of clinical and laboratory findings placed in the context of CV and oncological history is the safest way to patients' evaluation. For example, the differential diagnosis in the case of cTn elevation between cardiac injury caused by COVID‐19 and myocarditis due to concurrent immune checkpoint inhibitor (ICI) therapy, besides further clinical and laboratory findings, should take under consideration that COVID‐19‐related troponin elevation is frequent, particularly in the presence of CV comorbidities, while ICI‐related myocarditis is quite rare (<1%), being more possible during the first 4–6 weeks of ICI therapy and in the presence of combined ICI.

Angiotensin‐converting enzyme (ACE) inhibitors and angiotensin II receptor blockers represent the cornerstone therapy for myocardial dysfunction caused by anticancer therapy and are also widely used for the treatment of arterial hypertension among cancer patients and survivors. The knowledge that the SARS‐CoV‐2 uses ACE II (ACE2) receptor for its cell entry, gave rise to multiple pathophysiological hypotheses of potential harm or benefit. Given the complexity of the issue and the lack of solid evidence on either harm or benefit in the context of COVID‐19, CV societies across the world has recently released statements recommending the continuation of these drugs. Recently published data support these recommendations as inhibitors of the renin–angiotensin system are not associated with higher plasma ACE2 concentrations or increased risk for COVID‐19.

In the field of research, recruitment of patients has been at least temporarily stopped for all non COVID‐19 trials. Ongoing trials have modified follow‐up to balance compliance with minimal exposure of participants to COVID‐19. Running cardio‐oncology registries in parallel to the numerous currently ongoing COVID‐19 studies and surveys would record clinical experience and generate valuable evidence for this vulnerable population.

The current COVID‐19 pandemic and previous coronavirus outbreaks show that probability of a new epidemic caused by the same or similar airborne viruses in the near future is quite high. Therefore, the proposed adaptations of cardio‐oncology services (Table ) may constitute the core of a pre‐defined plan of care ready to become effective immediately in the case of a new epidemic. The three pillars of this plan should consist of the exploitation of the current telecommunication technologies, including the recent smartphone/watch or other wearable device applications, that allow replacement of conventional clinic visits with remote consultation and telemonitoring of patients at home, the selective use of diagnostic modalities such as imaging, and the constant provision of updated information to patients.

The COVID‐19 pandemic imposes the implementation of strategies that will limit exposure of the vulnerable cardio‐oncology patient population without compromising the essentials of their healthcare. Cardio‐oncology services need to adapt efficiently to deal with the unprecedented challenges in everyday clinical practice during the present and future pandemics (Figure ). At the same time, this outbreak can pave the road to shape specific disciplines and establish mechanisms that would be useful for every similar crisis in the future.

Figure 1

Main adaptations and challenges in cardio‐oncology services during the COVID‐19 pandemic.