Mindy C DeRouen1,2,3, Meg McKinley4, Sumit Anil Shah5,6, Hala T Borno7,8, Rhonda Aoki9, Daphne Y Lichtensztajn10,4, John T Leppert6,11,12, James D Brooks6,12, Benjamin I Chung6,12, Scarlett Lin Gomez10,7,4, Iona Cheng10,7,4. 1. Department of Epidemiology and Biostatistics, University of California San Francisco, San Francisco, CA, USA. mderouen@psg.ucsf.edu. 2. UCSF Helen Diller Family Comprehensive Cancer Center, San Francisco, CA, USA. mderouen@psg.ucsf.edu. 3. , 2nd Floor, 550 16th St, Stanford, CA, 94158, USA. mderouen@psg.ucsf.edu. 4. Greater Bay Area Cancer Registry, San Francisco, CA, USA. 5. Division of Oncology, Department of Medicine, Stanford School of Medicine, Stanford, CA, USA. 6. Stanford Cancer Institute, Stanford, CA, USA. 7. UCSF Helen Diller Family Comprehensive Cancer Center, San Francisco, CA, USA. 8. Division of Hematology/Oncology, Department of Medicine, School of Medicine, University of California San Francisco, San Francisco, CA, USA. 9. Department of Health Research and Policy, Stanford School of Medicine, Stanford, CA, USA. 10. Department of Epidemiology and Biostatistics, University of California San Francisco, San Francisco, CA, USA. 11. Division of Urology, Veterans Affairs Palo Alto Health Care System, Palo Alto, CA, USA. 12. Department of Urology, Stanford School of Medicine, Stanford, CA, USA.
Abstract
PURPOSE: Hispanic men in the USA experience the second-highest incidence rate of testicular germ cell tumors (TGCTs), behind non-Hispanic (NH) White men, and have experienced steep increases in TGCT in recent decades. It is unknown whether increases in incidence differ according to neighborhood sociodemographic factors. METHODS: We conducted a population-based study of n = 3759 Hispanic and n = 8469 NH White men (n = 12,228 total) diagnosed with TGCT in California during the three most recent pericensal periods. We calculated incidence rates according to neighborhood socioeconomic status (nSES) and among Hispanics, according to ethnic enclave. We calculated incidence rate ratios to compare rates across nSES and ethnic enclave and to examine changes in rates over pericensal time periods according to these neighborhood factors for major histologic types (i.e., seminoma and nonseminoma). RESULTS: Hispanic men residing in high SES, compared to low SES, neighborhoods had greater incidence of seminoma and nonseminoma testicular cancer across pericensal periods, as did Hispanic men in low enclave (less ethnic), compared to high enclave, neighborhoods. Between the periods 1998-2002 and 2008-2012, Hispanic men residing in low SES neighborhoods experienced a 39% increased incidence of seminoma, while those residing in low and middle SES neighborhoods experienced 87% and 48% increased incidence of nonseminoma, respectively. CONCLUSION: While TGCT incidence has increased among all Hispanic men, incidence increases appear to be driven disproportionately by those residing in lower SES and lower enclave neighborhoods, particularly for nonseminoma.
PURPOSE: Hispanic men in the USA experience the second-highest incidence rate of testicular germ cell tumors (TGCTs), behind non-Hispanic (NH) White men, and have experienced steep increases in TGCT in recent decades. It is unknown whether increases in incidence differ according to neighborhood sociodemographic factors. METHODS: We conducted a population-based study of n = 3759 Hispanic and n = 8469 NH White men (n = 12,228 total) diagnosed with TGCT in California during the three most recent pericensal periods. We calculated incidence rates according to neighborhood socioeconomic status (nSES) and among Hispanics, according to ethnic enclave. We calculated incidence rate ratios to compare rates across nSES and ethnic enclave and to examine changes in rates over pericensal time periods according to these neighborhood factors for major histologic types (i.e., seminoma and nonseminoma). RESULTS: Hispanic men residing in high SES, compared to low SES, neighborhoods had greater incidence of seminoma and nonseminoma testicular cancer across pericensal periods, as did Hispanic men in low enclave (less ethnic), compared to high enclave, neighborhoods. Between the periods 1998-2002 and 2008-2012, Hispanic men residing in low SES neighborhoods experienced a 39% increased incidence of seminoma, while those residing in low and middle SES neighborhoods experienced 87% and 48% increased incidence of nonseminoma, respectively. CONCLUSION: While TGCT incidence has increased among all Hispanic men, incidence increases appear to be driven disproportionately by those residing in lower SES and lower enclave neighborhoods, particularly for nonseminoma.
Entities:
Keywords:
Ethnic enclave; Incidence; Neighborhood; Race/ethnicity; Socioeconomic status; Testicular cancer
Authors: Rodrigo González-Barrios; Nicolás Alcaraz; Michel Montalvo-Casimiro; Alejandra Cervera; Cristian Arriaga-Canon; Paulina Munguia-Garza; Diego Hinojosa-Ugarte; Nora Sobrevilla-Moreno; Karla Torres-Arciga; Julia Mendoza-Perez; José Diaz-Chavez; Carlo Cesar Cortes-González; Clementina Castro-Hernández; Jorge Martínez-Cedillo; Ana Scavuzzo; Delia Pérez-Montiel; Miguel A Jiménez-Ríos; Luis A Herrera Journal: Cancers (Basel) Date: 2022-04-20 Impact factor: 6.575
Authors: Hanxiao Sun; Meng Lin; Emily M Russell; Ryan L Minster; Tsz Fung Chan; Bryan L Dinh; Take Naseri; Muagututi'a Sefuiva Reupena; Annette Lum-Jones; Iona Cheng; Lynne R Wilkens; Loïc Le Marchand; Christopher A Haiman; Charleston W K Chiang Journal: PLoS Genet Date: 2021-02-11 Impact factor: 5.917
Authors: Klaus-Peter Dieckmann; Tomas Pokrivcak; Lajos Geczi; David Niehaus; Inken Dralle-Filiz; Cord Matthies; Tamas Dienes; Stefanie Zschäbitz; Pia Paffenholz; Tanja Gschliesser; Renate Pichler; Michal Mego; Pia Bader; Friedemann Zengerling; Julia Heinzelbecker; Philipp Krausewitz; Susanne Krege; Gaetano Aurilio; Cem Aksoy; Marcus Hentrich; Christoph Seidel; Péter Törzsök; Tim Nestler; Matthaeus Majewski; Andreas Hiester; Tomas Buchler; Sonia Vallet; Hana Studentova; Sandra Schönburg; Dora Niedersüß-Beke; Julia Ring; Emanuela Trenti; Axel Heidenreich; Christian Wülfing; Hendrik Isbarn; Uwe Pichlmeier; Martin Pichler Journal: Ther Adv Med Oncol Date: 2022-03-31 Impact factor: 8.168