Literature DB >> 32439987

A new diketopiperazine-like inhibitor of bone morphogenetic protein-induced osteoblastic differentiation produced by marine-derived Aspergillus sp. BFM-0085.

Satoshi Ohte1,2,3, Takehiro Shiokawa2, Nobuhiro Koyama1,2,3, Takenobu Katagiri4, Chiaki Imada5, Hiroshi Tomoda6,7,8.   

Abstract

A new diketopiperazine-like compound, designated protuboxepin K (1), was isolated together with the known structurally related protuboxepin A (2) from culture broth of the marine-derived fungal strain Aspergillus sp. BFM-0085 isolated from a sediment sample of Tokyo Bay. The structure of protuboxepin K was elucidated by spectroscopic data, including 1D and 2D NMR. Compounds 1 and 2 inhibited bone morphogenetic protein (BMP)-induced alkaline phosphatase activity with IC50 values of 4.7 and 25.2 μM, respectively, in mutant BMP receptor-carrying C2C12(R206H) cells.

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Year:  2020        PMID： 32439987     DOI： 10.1038/s41429-020-0316-3

Source DB:  PubMed          Journal:  J Antibiot (Tokyo)        ISSN： 0021-8820            Impact factor:   2.649


  4 in total

Review 1.  Metabolites of Marine Sediment-Derived Fungi: Actual Trends of Biological Activity Studies.

Authors:  Anton N Yurchenko; Elena V Girich; Ekaterina A Yurchenko
Journal:  Mar Drugs       Date:  2021-02-04       Impact factor: 5.118

2.  Screening for Small Molecule Inhibitors of BMP-Induced Osteoblastic Differentiation from Indonesian Marine Invertebrates.

Authors:  Hiroyuki Yamazaki; Satoshi Ohte; Henki Rotinsulu; Defny S Wewengkang; Deiske A Sumilat; Delfly B Abdjul; Wilmar Maarisit; Magie M Kapojos; Michio Namikoshi; Takenobu Katagiri; Hiroshi Tomoda; Ryuji Uchida
Journal:  Mar Drugs       Date:  2020-11-30       Impact factor: 5.118

Review 3.  Structures and Biological Activities of Diketopiperazines from Marine Organisms: A Review.

Authors:  Zhiqiang Song; Yage Hou; Qingrong Yang; Xinpeng Li; Shaohua Wu
Journal:  Mar Drugs       Date:  2021-07-21       Impact factor: 5.118

Review 4.  Cyclic Dipeptides: The Biological and Structural Landscape with Special Focus on the Anti-Cancer Proline-Based Scaffold.

Authors:  Joanna Bojarska; Adam Mieczkowski; Zyta M Ziora; Mariusz Skwarczynski; Istvan Toth; Ahmed O Shalash; Keykavous Parang; Shaima A El-Mowafi; Eman H M Mohammed; Sherif Elnagdy; Maha AlKhazindar; Wojciech M Wolf
Journal:  Biomolecules       Date:  2021-10-14
  4 in total

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