Literature DB >> 324392

Comparison of the actions of 5-fluorouracil and ftorafur in Escherichia coli.

P P Saunders, L Y Chao.   

Abstract

The actions of 5-fluorouracil (FU) and Ftorafur (NCS 148958) were compared in Escherichia coli B3 to determine if Ftorafur can act in ways other than through the production of FU. Very high concentrations of Ftorafur relative to FU were necessary to achieve a comparable inhibition of cell growth. Inhibition by both agents could be reversed by uracil. An FU-resistant strain and an Ftorafur-resistant strain were isolated and found to be cross-resistant to Ftorafur and FU, respectively.

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Year:  1977        PMID： 324392      PMCID： PMC352006          DOI： 10.1128/AAC.11.3.451

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  7 in total

1.  In vitro biological evaluation of the R and S isomers of 1-(Tetrahydrofuran-2-yl)-5-fluorouracil.

Authors:  J P Horwitz; J J McCormick; K D Philips; V M Maher; J R Otto; D Kessel; J Zemlicka
Journal:  Cancer Res       Date:  1975-05       Impact factor: 12.701

2.  The mechanism of an osmotic instability induced in E. coli K-12 by 5-fluorouracil.

Authors:  A TOMASZ; E BOREK
Journal:  Biochemistry       Date:  1962-07       Impact factor: 3.162

3.  Fluorinated pyrimidines, a new class of tumour-inhibitory compounds.

Authors:  C HEIDELBERGER; N K CHAUDHURI; P DANNEBERG; D MOOREN; L GRIESBACH; R DUSCHINSKY; R J SCHNITZER; E PLEVEN; J SCHEINER
Journal:  Nature       Date:  1957-03-30       Impact factor: 49.962

4.  Properties of 5-fluorouracil-containing ribonucleic acid and ribosomes from Bacillus subtilis.

Authors:  P P Saunders; R E Bass; G F Saunders
Journal:  J Bacteriol       Date:  1968-08       Impact factor: 3.490

5.  Formation and fate of abnormal ribosomes of E. coli cells treated with 5-fluorouracil.

Authors:  T Andoh; E Chargaff
Journal:  Proc Natl Acad Sci U S A       Date:  1965-10       Impact factor: 11.205

Review 6.  Investigational drugs under study by the United States National Cancer Institute.

Authors:  S K Carter; M Slavik
Journal:  Cancer Treat Rev       Date:  1976-03       Impact factor: 12.111

7.  Miscoding caused by 5-fluorouracil.

Authors:  B Rosen; F Rothman; M G Weigert
Journal:  J Mol Biol       Date:  1969-09-14       Impact factor: 5.469
  7 in total

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