Literature DB >> 32439105

The Dual Role of Serotonin in Colorectal Cancer.

Vinicius Kannen1, Michael Bader2, Juliana Y Sakita3, Sergio A Uyemura4, Jeremy A Squire5.   

Abstract

Serotonin (5-HT) has complex effects on the central nervous system (CNS), neuroendocrine mechanisms, immunological reactions, intestinal microbiome, and cancer. It has been associated with more severe signs and symptoms of colitis, as well as promoting colorectal cancer (CRC) cells toward expansion. However, recent findings revealed that impairments in 5-HT synthesis lead to high levels of DNA damage in colonocytes, which is linked with inflammatory reactions promoting the development of CRC. Here, we review the diverse roles of 5-HT in intestinal homeostasis and in CRC and discuss how improved understanding of the modulation of the 5-HT pathway could be helpful for the design of novel anticancer therapies.
Copyright © 2020 Elsevier Ltd. All rights reserved.

Entities:  

Keywords:  colon tumors; enterochromaffin cells; intestinal molecules; preneoplastic lesions

Mesh：

Substances：

Year:  2020        PMID： 32439105     DOI： 10.1016/j.tem.2020.04.008

Source DB:  PubMed          Journal:  Trends Endocrinol Metab        ISSN： 1043-2760            Impact factor:   12.015


  11 in total

Review 1.  Neurotransmitter signaling: a new frontier in colorectal cancer biology and treatment.

Authors:  Francesca Battaglin; Priya Jayachandran; Carly Strelez; Annika Lenz; Sandra Algaze; Shivani Soni; Jae Ho Lo; Yan Yang; Joshua Millstein; Wu Zhang; Evanthia T Roussos Torres; Jean C Shih; Shannon M Mumenthaler; Josh Neman; Heinz-Josef Lenz
Journal:  Oncogene       Date:  2022-10-01       Impact factor: 8.756

2.  5-HT2B-mediated serotonin activation in enterocytes suppresses colitis-associated cancer initiation and promotes cancer progression.

Authors:  Liyuan Mao; Fang Xin; Jie Ren; Shuai Xu; Haixia Huang; Xu Zha; Xinxin Wen; Guoqing Gu; Guang Yang; Yuan Cheng; Chen Zhang; Wei Wang; Xicheng Liu
Journal:  Theranostics       Date:  2022-05-09       Impact factor: 11.600

3.  Upregulation of miR-361-3p suppresses serotonin-induced proliferation in human pulmonary artery smooth muscle cells by targeting SERT.

Authors:  Ying Zhang; Yongbin Chen; Guo Chen; Yingling Zhou; Hua Yao; Hong Tan
Journal:  Cell Mol Biol Lett       Date:  2020-10-07       Impact factor: 5.787

4.  A Systems Biology Approach to Investigating the Interaction between Serotonin Synthesis by Tryptophan Hydroxylase and the Metabolic Homeostasis.

Authors:  Suhyeon Park; Yumin Kim; Jibeom Lee; Jeong Yun Lee; Hail Kim; Sunjae Lee; Chang-Myung Oh
Journal:  Int J Mol Sci       Date:  2021-02-28       Impact factor: 5.923

Review 5.  Targeting Dietary and Microbial Tryptophan-Indole Metabolism as Therapeutic Approaches to Colon Cancer.

Authors:  Madhur Wyatt; K Leigh Greathouse
Journal:  Nutrients       Date:  2021-04-03       Impact factor: 5.717

6.  Targeting SERT promotes tryptophan metabolism: mechanisms and implications in colon cancer treatment.

Authors:  Di Ye; Huanji Xu; Hongwei Xia; Chenliang Zhang; Qiulin Tang; Feng Bi
Journal:  J Exp Clin Cancer Res       Date:  2021-05-18

Review 7.  Immunosuppressive metabolites in tumoral immune evasion: redundancies, clinical efforts, and pathways forward.

Authors:  Maria Rain Jennings; David Munn; John Blazeck
Journal:  J Immunother Cancer       Date:  2021-10       Impact factor: 13.751

8.  Tryptophan hydroxylase 1 drives glioma progression by modulating the serotonin/L1CAM/NF-κB signaling pathway.

Authors:  Jie Zhang; Zhangchao Guo; Qiangli Xie; Chuanhong Zhong; Xiangyu Gao; Qiumei Yang
Journal:  BMC Cancer       Date:  2022-04-26       Impact factor: 4.638

9.  Circulating tryptophan metabolites and risk of colon cancer: Results from case-control and prospective cohort studies.

Authors:  Nikos Papadimitriou; Marc J Gunter; Neil Murphy; Audrey Gicquiau; David Achaintre; Stefanie Brezina; Tanja Gumpenberger; Andreas Baierl; Jennifer Ose; Anne J M R Geijsen; Eline H van Roekel; Andrea Gsur; Biljana Gigic; Nina Habermann; Cornelia M Ulrich; Ellen Kampman; Matty P Weijenberg; Per Magne Ueland; Rudolf Kaaks; Verena Katzke; Vittorio Krogh; Bas Bueno-de-Mesquita; Eva Ardanaz; Ruth C Travis; Matthias B Schulze; Maria-José Sánchez; Sandra M Colorado-Yohar; Elisabete Weiderpass; Augustin Scalbert; Pekka Keski-Rahkonen
Journal:  Int J Cancer       Date:  2021-07-12       Impact factor: 7.396

10.  Revised Exon Structure of l-DOPA Decarboxylase (DDC) Reveals Novel Splice Variants Associated with Colorectal Cancer Progression.

Authors:  Pinelopi I Artemaki; Maria Papatsirou; Michaela A Boti; Panagiotis G Adamopoulos; Spyridon Christodoulou; Dido Vassilacopoulou; Andreas Scorilas; Christos K Kontos
Journal:  Int J Mol Sci       Date:  2020-11-13       Impact factor: 5.923
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