| Literature DB >> 32439019 |
Manuel F Casanova1, Estate M Sokhadze2, Emily L Casanova3, Ioan Opris4, Caio Abujadi5, Marco Antonio Marcolin6, Xiaoli Li7.
Abstract
The presence of heterotopias, increased regional density of neurons at the gray-white matter junction, and focal cortical dysplasias all suggest an abnormality of neuronal migration in autism spectrum disorder (ASD). The abnormality is borne from a dissonance in timing between radial and tangentially migrating neuroblasts to the developing cortical plate. The uncoupling of excitatory and inhibitory cortical cells disturbs the coordinated interactions of neurons within local networks, thus providing abnormal patterns of brainwave activity in the gamma bandwidth. In ASD, gamma oscillation abnormalities and autonomic markers offer measures of therapeutic progress and help in the identification of subgroups.Entities:
Keywords: Autism spectrum disorder; Executive function; Gamma oscillations; Minicolumns; Transcranial magnetic stimulation
Mesh：
Year: 2020 PMID： 32439019 PMCID： PMC7245584 DOI： 10.1016/j.psc.2020.02.004
Source DB: PubMed Journal: Psychiatr Clin North Am ISSN： 0193-953X