Katharina Blumchen1, Audrey DunnGalvin2,3, Frans Timmermans4, Lynne Regent5, Sabine Schnadt6, Marcia Podestà7, Angel Sánchez8, Pascale Couratier9, Mary Feeney10, Betina Hjorth11, Ram Patel12, Tessa Lush13, Robert Ryan13, Andrea Vereda13, Helen R Fisher10, Montserrat Fernández-Rivas14. 1. Division of Allergology, Pneumology and Cystic Fibrosis, Department of Children and Adolescent Medicine, University Hospital Frankfurt, Frankfurt am Main, Germany. 2. School of Applied Psychology and Department of Paediatrics and Child Health, University College Cork, Cork, Ireland. 3. Paediatrics and Child Infectious Diseases, First Moscow State Medical University, Moscow, Russia. 4. Nederlands Anafylaxis Netwerk - European Anaphylaxis Taskforce, Dordrecht, The Netherlands. 5. Anaphylaxis Campaign, Farnborough, UK. 6. Deutscher Allergie- und Asthmabund, (DAAB), Mönchengladbach, Germany. 7. Food Allergy Italia, Padua, Italy. 8. Asociación Española de Personas con Alergia a Alimentos y Látex (AEPNAA), Madrid, Spain. 9. Association Française de Prévention des Allergies (AFPRAL), Paris, France. 10. Division of Asthma, Allergy and Lung Biology, Department of Paediatric Allergy, King's College London, and Guy's and St. Thomas' NHS Foundation Trust, London, UK. 11. Astma-Allergi Danmark, Roskilde, Denmark. 12. Brainsell Ltd., London, UK. 13. Aimmune Therapeutics, London, UK. 14. Department of Allergy, Hospital Clínico San Carlos, Universidad Complutense de Madrid, IdISSC, ARADyAL, Madrid, Spain.
Abstract
BACKGROUND: Peanut allergy (PA) is associated with marked quality-of-life (QoL) impairment. However, data are lacking on the experience and impact of living with PA from the perspectives of persons with PA (PwPA) and their caregivers. Allergy to Peanuts imPacting Emotions And Life study 1 (APPEAL-1) was a pan-European survey investigating these perspectives. This first of two articles reports clinical characteristics of PwPA and PA management practices. METHODS: APPEAL-1 was a quantitative, online survey conducted in eight European countries, developed by eight representatives of patient advocacy groups and five healthcare professionals and researchers. Eligible participants included adults with PA and parents/caregivers of PwPA who responded by self-report and provided proxy-report for the PwPA under their care. Data were summarized using nonweighted descriptive statistics. RESULTS: Of 1846 completed/analysed questionnaires, 528 were from adults with PA (self-report); 437 by proxy for children with PA (34 aged 0-3 years, 287 aged 4-12 years, 116 aged 13-17 years) and 881 from parents/caregivers (self-report). Of PwPA (N = 965), 95% reported diagnosis by healthcare professionals, mostly by clinical history and peanut-specific allergy testing. Rates of allergic rhinitis, asthma and other food allergies in PwPA were 50%, 42% and 79%, respectively. Only 31% of PwPA received HCP advice/support following their worst allergic reaction, and 28% had not been prescribed an adrenaline auto-injector. Results were similar by country but varied by age group. CONCLUSIONS: The APPEAL-1 findings contribute to greater understanding of PA impact on PwPA, caregivers and family members and the need for improved PA management across Europe.
BACKGROUND:Peanutallergy (PA) is associated with marked quality-of-life (QoL) impairment. However, data are lacking on the experience and impact of living with PA from the perspectives of persons with PA (PwPA) and their caregivers. Allergy to Peanuts imPacting Emotions And Life study 1 (APPEAL-1) was a pan-European survey investigating these perspectives. This first of two articles reports clinical characteristics of PwPA and PA management practices. METHODS: APPEAL-1 was a quantitative, online survey conducted in eight European countries, developed by eight representatives of patient advocacy groups and five healthcare professionals and researchers. Eligible participants included adults with PA and parents/caregivers of PwPA who responded by self-report and provided proxy-report for the PwPA under their care. Data were summarized using nonweighted descriptive statistics. RESULTS: Of 1846 completed/analysed questionnaires, 528 were from adults with PA (self-report); 437 by proxy for children with PA (34 aged 0-3 years, 287 aged 4-12 years, 116 aged 13-17 years) and 881 from parents/caregivers (self-report). Of PwPA (N = 965), 95% reported diagnosis by healthcare professionals, mostly by clinical history and peanut-specific allergy testing. Rates of allergic rhinitis, asthma and other food allergies in PwPA were 50%, 42% and 79%, respectively. Only 31% of PwPA received HCP advice/support following their worst allergic reaction, and 28% had not been prescribed an adrenaline auto-injector. Results were similar by country but varied by age group. CONCLUSIONS: The APPEAL-1 findings contribute to greater understanding of PA impact on PwPA, caregivers and family members and the need for improved PA management across Europe.
Authors: Montserrat Fernandez-Rivas; Andrea Vereda; Brian P Vickery; Vibha Sharma; Caroline Nilsson; Antonella Muraro; Jonathan O'B Hourihane; Audrey DunnGalvin; George du Toit; Katharina Blumchen; Kirsten Beyer; Alex Smith; Robert Ryan; Daniel C Adelman; Stacie M Jones Journal: Allergy Date: 2021-09-24 Impact factor: 14.710