Celestina Barbosa-Leiker1,2, Aimee N C Campbell3, Martina Pavlicova4, Jennifer Scodes5, A Kathleen Burlew6, Mary Hatch-Maillette7, Sarah E Mennenga8, Shannon G Mitchell9, Patricia Novo8, Edward V Nunes3, John Rotrosen8, Shelly F Greenfield10. 1. College of Nursing, Washington State University, Spokane, Washington. 2. Program of Excellence in Addictions Research, Washington State University, Spokane, Washington. 3. Department of Psychiatry, Columbia University Irving Medical Center and New York State Psychiatric Institute, New York, New York. 4. Department of Biostatistics, Columbia University Mailman School of Public Health, New York, New York. 5. Division of Mental Health Data Science, New York State Psychiatric Institute, New York, New York. 6. University of Cincinnati, Cincinnati, Ohio. 7. Department of Psychiatry and Behavioral Sciences, Alcohol and Drug Abuse Institute, University of Washington, Seattle, Washington. 8. Department of Psychiatry, New York University Grossman School of Medicine, New York, New York. 9. Friends Research Institute, Inc, Baltimore, Maryland. 10. Department of Psychiatry, Harvard Medical School, McLean Hospital, Belmont, Massachusetts.
Abstract
BACKGROUND AND OBJECTIVES: We examined age differences across genders in clinical characteristics in emerging adult (≤25 years) vs older adult patients (26+ years) with opioid use disorder (OUD). METHODS: Participants (N = 570; 30% female) entering a comparative effectiveness medication trial of buprenorphine vs extended-release naltrexone. RESULTS: Differences in clinical characteristics in emerging adult vs older participants were similar across genders. However, women 26+ years reported more mental health problems compared with women ≤25, while men ≤25 years reported more mental health problems compared with men 26+ years. DISCUSSION AND CONCLUSION: Different strategies for emerging adult and older patients seeking OUD treatment may be necessary to address psychiatric comorbidities that differ across genders in this population. SCIENTIFIC SIGNIFICANCE: Comprehensive psychiatric assessment should be systematically included in OUD treatment for all genders. Treatment should focus on the emerging adult developmental phase when appropriate, with psychiatric treatment tailored for women and men, separately, across the lifespan. (Am J Addict 2020;29:536-542).
BACKGROUND AND OBJECTIVES: We examined age differences across genders in clinical characteristics in emerging adult (≤25 years) vs older adult patients (26+ years) with opioid use disorder (OUD). METHODS:Participants (N = 570; 30% female) entering a comparative effectiveness medication trial of buprenorphine vs extended-release naltrexone. RESULTS: Differences in clinical characteristics in emerging adult vs older participants were similar across genders. However, women 26+ years reported more mental health problems compared with women ≤25, while men ≤25 years reported more mental health problems compared with men 26+ years. DISCUSSION AND CONCLUSION: Different strategies for emerging adult and older patients seeking OUD treatment may be necessary to address psychiatric comorbidities that differ across genders in this population. SCIENTIFIC SIGNIFICANCE: Comprehensive psychiatric assessment should be systematically included in OUD treatment for all genders. Treatment should focus on the emerging adult developmental phase when appropriate, with psychiatric treatment tailored for women and men, separately, across the lifespan. (Am J Addict 2020;29:536-542).
Authors: Cynthia I Campbell; Constance Weisner; Linda Leresche; G Thomas Ray; Kathleen Saunders; Mark D Sullivan; Caleb J Banta-Green; Joseph O Merrill; Michael J Silverberg; Denise Boudreau; Derek D Satre; Michael Von Korff Journal: Am J Public Health Date: 2010-08-19 Impact factor: 9.308
Authors: Justine W Welsh; Lora L Passetti; Rodney R Funk; Jane Ellen Smith; Robert J Meyers; Mark D Godley Journal: J Psychoactive Drugs Date: 2019-05-14
Authors: Joshua D Lee; Edward V Nunes; Patricia Novo Mpa; Genie L Bailey; Gregory S Brigham; Allan J Cohen; Marc Fishman; Walter Ling; Robert Lindblad; Dikla Shmueli-Blumberg; Don Stablein; Jeanine May; Dagmar Salazar; David Liu; John Rotrosen Journal: Contemp Clin Trials Date: 2016-08-10 Impact factor: 2.226
Authors: Joshua D Lee; Edward V Nunes; Patricia Novo; Ken Bachrach; Genie L Bailey; Snehal Bhatt; Sarah Farkas; Marc Fishman; Phoebe Gauthier; Candace C Hodgkins; Jacquie King; Robert Lindblad; David Liu; Abigail G Matthews; Jeanine May; K Michelle Peavy; Stephen Ross; Dagmar Salazar; Paul Schkolnik; Dikla Shmueli-Blumberg; Don Stablein; Geetha Subramaniam; John Rotrosen Journal: Lancet Date: 2017-11-14 Impact factor: 79.321
Authors: James R Langabeer; Tiffany Champagne-Langabeer; Andrea J Yatsco; Meredith M O'Neal; Marylou Cardenas-Turanzas; Samuel Prater; Samuel Luber; Angela Stotts; Tom Fadial; Gina Khraish; Henry Wang; Bentley J Bobrow; Kimberly A Chambers Journal: J Am Coll Emerg Physicians Open Date: 2021-03-31