Zoya Gridneva1, Ching T Lai2, Alethea Rea3, Wan J Tie2, Leigh C Ward4, Kevin Murray5, Peter E Hartmann2, Donna T Geddes2. 1. School of Molecular Sciences, The University of Western Australia, Crawley, WA, Australia. zoya.gridneva@uwa.edu.au. 2. School of Molecular Sciences, The University of Western Australia, Crawley, WA, Australia. 3. Mathematics and Statistics, Murdoch University, Murdoch, WA, Australia. 4. School of Chemistry and Molecular Biosciences, The University of Queensland, St. Lucia, QLD, Australia. 5. School of Population and Global Health, The University of Western Australia, Crawley, WA, Australia.
Abstract
BACKGROUND: To investigate relationships between infant body composition (BC) and human milk (HM) immunomodulatory proteins (IMPs) during the first 12 months of lactation. METHODS: BC of breastfeeding dyads (n = 20) was measured with ultrasound skinfolds (infants) and bioimpedance spectroscopy (infants/mothers) at 2, 5, 9, and/or 12 months post partum. Breastfeeding frequency, 24-h milk intake, and IMP concentrations (lactoferrin, lysozyme, secretory immunoglobulin A (sIgA)) were measured, and calculated daily intakes (CDIs) were determined. We used linear regression/mixed-effects models and adjusted results for multiple comparisons. RESULTS: No associations were seen between maternal characteristics and IMP concentrations/CDIs or between IMP concentrations and infant BC. Lactoferrin CDI was negatively associated with infant fat-free mass index (P = 0.002); lysozyme CDI was positively associated with infant fat mass (P = 0.004) and fat mass index (P = 0.004) measured with ultrasound skinfolds. CONCLUSION: In this small cohort of infants breastfed on demand during first year of life, we report differential associations of HM IMPs with infant BC, showing that in addition to their critical role in shaping infant immunity, lactoferrin, and lysozyme also influence development of infant BC, highlighting the importance of breastfeeding for 12 months and beyond. IMPACT: HM IMPs (concentrations and, most importantly, daily intakes) time-dependently and differentially associate with development of infant lean mass and adiposity during first 12 months of lactation. There is no information on how intakes and concentrations of these components affect development of infant BC. HM contains IMPs-lactoferrin, lysozyme, and sIgA, which not only play a critical role in shaping infant's immunity, but also influence infant growth and development of BC, highlighting the importance of breastfeeding for 12 months and beyond and warranting careful consideration of the dose effects of supplemented formula.
BACKGROUND: To investigate relationships between infant body composition (BC) and human milk (HM) immunomodulatory proteins (IMPs) during the first 12 months of lactation. METHODS: BC of breastfeeding dyads (n = 20) was measured with ultrasound skinfolds (infants) and bioimpedance spectroscopy (infants/mothers) at 2, 5, 9, and/or 12 months post partum. Breastfeeding frequency, 24-h milk intake, and IMP concentrations (lactoferrin, lysozyme, secretory immunoglobulin A (sIgA)) were measured, and calculated daily intakes (CDIs) were determined. We used linear regression/mixed-effects models and adjusted results for multiple comparisons. RESULTS: No associations were seen between maternal characteristics and IMP concentrations/CDIs or between IMP concentrations and infant BC. Lactoferrin CDI was negatively associated with infant fat-free mass index (P = 0.002); lysozyme CDI was positively associated with infant fat mass (P = 0.004) and fat mass index (P = 0.004) measured with ultrasound skinfolds. CONCLUSION: In this small cohort of infants breastfed on demand during first year of life, we report differential associations of HM IMPs with infant BC, showing that in addition to their critical role in shaping infant immunity, lactoferrin, and lysozyme also influence development of infant BC, highlighting the importance of breastfeeding for 12 months and beyond. IMPACT: HM IMPs (concentrations and, most importantly, daily intakes) time-dependently and differentially associate with development of infant lean mass and adiposity during first 12 months of lactation. There is no information on how intakes and concentrations of these components affect development of infant BC. HM contains IMPs-lactoferrin, lysozyme, and sIgA, which not only play a critical role in shaping infant's immunity, but also influence infant growth and development of BC, highlighting the importance of breastfeeding for 12 months and beyond and warranting careful consideration of the dose effects of supplemented formula.
Authors: Xinliu Gao; Robert J McMahon; Jessica G Woo; Barbara S Davidson; Ardythe L Morrow; Qiang Zhang Journal: J Proteome Res Date: 2012-06-21 Impact factor: 4.466
Authors: Leonie Beljaars; Barry W A van der Strate; Hester I Bakker; Catharina Reker-Smit; Anne-Miek van Loenen-Weemaes; Frouwke C Wiegmans; Martin C Harmsen; Grietje Molema; Dirk K F Meijer Journal: Antiviral Res Date: 2004-09 Impact factor: 5.970
Authors: Zoya Gridneva; Alethea Rea; Ching Tat Lai; Wan Jun Tie; Sambavi Kugananthan; Ashleigh H Warden; Sharon L Perrella; Kevin Murray; Donna T Geddes Journal: Life (Basel) Date: 2022-03-28