Jeongshim Lee1,2, In-Soo Shin3, Woo Chul Kim1, Won Sup Yoon4, Woong Sub Koom2, Chai Hong Rim4. 1. Department of Radiation Oncology, Inha University Hospital, Inha University College of Medicine, Incheon, South Korea. 2. Department of Radiation Oncology, Yonsei University College of Medicine, Seoul, South Korea. 3. Graduate School of Education, Dongguk University, Seoul, South Korea. 4. Department of Radiation Oncology, Ansan Hospital, Korea University Medical College, Ansan, South Korea.
Abstract
BACKGROUND: To summarize outcomes of reirradiation with intensity-modulated radiotherapy (IMRT) for recurrent or secondary head and neck cancer (HNC). METHODS: Primary endpoints were 2-year local control (LC) and overall survival (OS). Studies involving only recurrent nasopharyngeal patients with cancer were excluded. RESULTS: A total of 17 studies involving 1635 patients were included. Fourteen (82%) of those were retrospective, and 15 (88%) were from single institution. Reirradiation with IMRT produced pooled 2-year LC and OS rates of 52% (95% confidence interval [CI], 46%-57%) and 46% (95% CI, 41%-50%), respectively. In subgroup analyses, the rate of salvage surgery (<42% vs ≥42%) influenced the pooled 2-year LC rate (45.9% vs 58.5%, P = .011). The pooled rates of late grade ≥ 3 and grade 5 toxicities were 26% (95% CI, 20%-32%) and 3.1% (95% CI, 2%-5%), respectively. CONCLUSIONS: Reirradiation with IMRT was an effective modality compared to historical outcomes in the pre-IMRT era.
BACKGROUND: To summarize outcomes of reirradiation with intensity-modulated radiotherapy (IMRT) for recurrent or secondary head and neck cancer (HNC). METHODS: Primary endpoints were 2-year local control (LC) and overall survival (OS). Studies involving only recurrent nasopharyngeal patients with cancer were excluded. RESULTS: A total of 17 studies involving 1635 patients were included. Fourteen (82%) of those were retrospective, and 15 (88%) were from single institution. Reirradiation with IMRT produced pooled 2-year LC and OS rates of 52% (95% confidence interval [CI], 46%-57%) and 46% (95% CI, 41%-50%), respectively. In subgroup analyses, the rate of salvage surgery (<42% vs ≥42%) influenced the pooled 2-year LC rate (45.9% vs 58.5%, P = .011). The pooled rates of late grade ≥ 3 and grade 5 toxicities were 26% (95% CI, 20%-32%) and 3.1% (95% CI, 2%-5%), respectively. CONCLUSIONS: Reirradiation with IMRT was an effective modality compared to historical outcomes in the pre-IMRT era.
Authors: Mauricio E Gamez; Samir H Patel; Lisa A McGee; Terence T Sio; Mark McDonald; Jack Phan; Daniel J Ma; Robert L Foote; Jean-Claude M Rwigema Journal: Int J Part Ther Date: 2021-06-25
Authors: Franco Ionna; Paolo Bossi; Agostino Guida; Andrea Alberti; Paolo Muto; Giovanni Salzano; Alessandro Ottaiano; Fabio Maglitto; Davide Leopardo; Marco De Felice; Francesco Longo; Salvatore Tafuto; Giuseppina Della Vittoria Scarpati; Francesco Perri Journal: Cancers (Basel) Date: 2021-05-14 Impact factor: 6.639