| Literature DB >> 32435776 |
Aurore Fraix1, Cristina Parisi1, Mariacristina Failla2, Konstantin Chegaev3, Francesca Spyrakis3, Loretta Lazzarato3, Roberta Fruttero3, Alberto Gasco3, Salvatore Sortino1.
Abstract
We report for the first time a NO photodonor (NOPD) operating with the widely used chemotherapeutic agent doxorubicin (DOX) as the light-harvesting antenna. This permits NO uncaging from an N-nitroso appendage upon selective excitation of DOX with highly biocompatible green light, without precluding its typical red emission. This NOPD effectively binds DNA and photodelivers NO nearby, representing an intriguing candidate for potential multimodal therapeutic applications based on the combination of DOX and NO.Entities:
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Year: 2020 PMID： 32435776 DOI： 10.1039/d0cc02512g
Source DB: PubMed Journal: Chem Commun (Camb) ISSN： 1359-7345 Impact factor: 6.222