Literature DB >> 32435396

Inhibition of Human Immunodeficiency Virus-1 Integrase by β-Diketo Acid Coated Gold Nanoparticles.

Vanna Sanna1, Mohamed Fathy Youssef2, Nicolino Pala2, Dominga Rogolino3, Mauro Carcelli3, Pankaj Kumar Singh2, Tino Sanchez4, Nouri Neamati5, Mario Sechi2.   

Abstract

Gold nanoparticles (GNPs) have been proposed as carriers for drugs to improve their intrinsic therapeutic activities and to overcome pharmacokinetic problems. In this study, novel nanosystems constituted by a model β-diketo acid (DKA) grafted to the surface of GNPs were designed and synthesized following the "multivalent high-affinity" binding strategy. These first nanoscale DKA prototypes showed improved inhibition of HIV-1 integrase (HIV-1 IN) catalytic activities as compared with free DKA ligands.
Copyright © 2020 American Chemical Society.

Entities:  

Year:  2020        PMID： 32435396      PMCID： PMC7236234          DOI： 10.1021/acsmedchemlett.9b00648

Source DB:  PubMed          Journal:  ACS Med Chem Lett        ISSN： 1948-5875            Impact factor:   4.345


  36 in total

Review 1.  Self-assembled multivalency: dynamic ligand arrays for high-affinity binding.

Authors:  Anna Barnard; David K Smith
Journal:  Angew Chem Int Ed Engl       Date:  2012-06-11       Impact factor: 15.336

2.  Investigating the role of metal chelation in HIV-1 integrase strand transfer inhibitors.

Authors:  Alessia Bacchi; Mauro Carcelli; Carlotta Compari; Emilia Fisicaro; Nicolino Pala; Gabriele Rispoli; Dominga Rogolino; Tino W Sanchez; Mario Sechi; Valentina Sinisi; Nouri Neamati
Journal:  J Med Chem       Date:  2011-11-22       Impact factor: 7.446

3.  HIV-1 DNA integration: mechanism of viral DNA cleavage and DNA strand transfer.

Authors:  A Engelman; K Mizuuchi; R Craigie
Journal:  Cell       Date:  1991-12-20       Impact factor: 41.582

Review 4.  Multifaceted HIV integrase functionalities and therapeutic strategies for their inhibition.

Authors:  Alan N Engelman
Journal:  J Biol Chem       Date:  2019-08-29       Impact factor: 5.157

5.  Inhibitors of strand transfer that prevent integration and inhibit HIV-1 replication in cells.

Authors:  D J Hazuda; P Felock; M Witmer; A Wolfe; K Stillmock; J A Grobler; A Espeseth; L Gabryelski; W Schleif; C Blau; M D Miller
Journal:  Science       Date:  2000-01-28       Impact factor: 47.728

Review 6.  Nano-Medicine as a Newly Emerging Approach to Combat Human Immunodeficiency Virus (HIV).

Authors:  Muthupandian Saravanan; Tsehaye Asmalash; Atsebaha Gebrekidan; Dawit Gebreegziabiher; Tadele Araya; Haftamu Hilekiros; Hamed Barabadi; Kumaresan Ramanathan
Journal:  Pharm Nanotechnol       Date:  2018

7.  Quantification of ligand packing density on gold nanoparticles using ICP-OES.

Authors:  Sherrie Elzey; De-Hao Tsai; Savelas A Rabb; Lee L Yu; Michael R Winchester; Vincent A Hackley
Journal:  Anal Bioanal Chem       Date:  2012-02-18       Impact factor: 4.142

8.  Retroviral intasome assembly and inhibition of DNA strand transfer.

Authors:  Stephen Hare; Saumya Shree Gupta; Eugene Valkov; Alan Engelman; Peter Cherepanov
Journal:  Nature       Date:  2010-01-31       Impact factor: 49.962

9.  Gold nanoparticles to improve HIV drug delivery.

Authors:  Carolina Garrido; Carrie A Simpson; Noelle P Dahl; Jamee Bresee; Daniel C Whitehead; Erick A Lindsey; Tyler L Harris; Candice A Smith; Carly J Carter; Daniel L Feldheim; Christian Melander; David M Margolis
Journal:  Future Med Chem       Date:  2015       Impact factor: 3.808

10.  Inhibition of HIV fusion with multivalent gold nanoparticles.

Authors:  Mary-Catherine Bowman; T Eric Ballard; Christopher J Ackerson; Daniel L Feldheim; David M Margolis; Christian Melander
Journal:  J Am Chem Soc       Date:  2008-05-13       Impact factor: 15.419
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