Literature DB >> 32435389

Peptides Mimicking the β7/β8 Loop of HIV-1 Reverse Transcriptase p51 as "Hotspot-Targeted" Dimerization Inhibitors.

Pedro A Sánchez-Murcia1, Sonia de Castro1, Carlos García-Aparicio1, M Angeles Jiménez2, Angela Corona3, Enzo Tramontano3, Nicolas Sluis-Cremer4, Luis Menéndez-Arias5, Sonsoles Velázquez1, Federico Gago6, María-José Camarasa1.   

Abstract

A conformationally constrained short peptide designed to target a protein-protein interaction hotspot in HIV-1 reverse transcriptase (RT) disrupts p66-p51 interactions and paves the way to the development of novel RT dimerization inhibitors.
Copyright © 2020 American Chemical Society.

Entities:  

Year:  2020        PMID： 32435389      PMCID： PMC7236230          DOI： 10.1021/acsmedchemlett.9b00623

Source DB:  PubMed          Journal:  ACS Med Chem Lett        ISSN： 1948-5875            Impact factor:   4.345


  37 in total

1.  Functional characterization of chimeric reverse transcriptases with polypeptide subunits of highly divergent HIV-1 group M and O strains.

Authors:  L Menéndez-Arias; A Abraha; M E Quiñones-Mateu; A Mas; M J Camarasa; E J Arts
Journal:  J Biol Chem       Date:  2001-05-15       Impact factor: 5.157

2.  Structure-activity relationships of [2',5'-bis-O-(tert-butyldimethylsilyl)-beta-D-ribofuranosyl]- 3'-spiro-5' '-(4' '-amino-1' ',2' '-oxathiole-2' ',2' '-dioxide)thymine derivatives as inhibitors of HIV-1 reverse transcriptase dimerization.

Authors:  Nicolas Sluis-Cremer; Noureddine Hamamouch; Ana San Félix; Sonsoles Velazquez; Jan Balzarini; María-José Camarasa
Journal:  J Med Chem       Date:  2006-08-10       Impact factor: 7.446

3.  Dimerization of human immunodeficiency virus type 1 reverse transcriptase. A target for chemotherapeutic intervention.

Authors:  T Restle; B Müller; R S Goody
Journal:  J Biol Chem       Date:  1990-06-05       Impact factor: 5.157

Review 4.  TSAO derivatives, inhibitors of HIV-1 reverse transcriptase dimerization: recent progress.

Authors:  M J Camarasa; S Velázquez; A San-Félix; M J Pérez-Pérez; M C Bonache; S De Castro
Journal:  Curr Pharm Des       Date:  2006       Impact factor: 3.116

5.  Inhibition of HIV-1 Reverse Transcriptase Dimerization by Small Molecules.

Authors:  Cristina Tintori; Angela Corona; Francesca Esposito; Annalaura Brai; Nicole Grandi; Elisa Rita Ceresola; Massimo Clementi; Filippo Canducci; Enzo Tramontano; Maurizio Botta
Journal:  Chembiochem       Date:  2016-03-21       Impact factor: 3.164

Review 6.  TSAO derivatives the first non-peptide inhibitors of HIV-1 RT dimerization.

Authors:  María-José Camarasa; Sonsoles Velázquez; Ana San-Félix; María-Jesús Pérez-Pérez
Journal:  Antivir Chem Chemother       Date:  2005

7.  Analysis of amino acids in the beta7-beta8 loop of human immunodeficiency virus type 1 reverse transcriptase for their role in virus replication.

Authors:  Alok Mulky; B Christie Vu; Joan A Conway; Stephen H Hughes; John C Kappes
Journal:  J Mol Biol       Date:  2006-11-10       Impact factor: 5.469

8.  Inhibition of human immunodeficiency virus type 1 reverse transcriptase dimerization using synthetic peptides derived from the connection domain.

Authors:  G Divita; T Restle; R S Goody; J C Chermann; J G Baillon
Journal:  J Biol Chem       Date:  1994-05-06       Impact factor: 5.157

Review 9.  Structure and function of HIV-1 reverse transcriptase: molecular mechanisms of polymerization and inhibition.

Authors:  Stefan G Sarafianos; Bruno Marchand; Kalyan Das; Daniel M Himmel; Michael A Parniak; Stephen H Hughes; Eddy Arnold
Journal:  J Mol Biol       Date:  2008-11-03       Impact factor: 5.469

10.  Ribonuclease H/DNA Polymerase HIV-1 Reverse Transcriptase Dual Inhibitor: Mechanistic Studies on the Allosteric Mode of Action of Isatin-Based Compound RMNC6.

Authors:  Angela Corona; Rita Meleddu; Francesca Esposito; Simona Distinto; Giulia Bianco; Takashi Masaoka; Elias Maccioni; Luis Menéndez-Arias; Stefano Alcaro; Stuart F J Le Grice; Enzo Tramontano
Journal:  PLoS One       Date:  2016-01-22       Impact factor: 3.240
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  3 in total

1.  Relative domain orientation of the L289K HIV-1 reverse transcriptase monomer.

Authors:  Zhaoyong Xi; Tatiana V Ilina; Michel Guerrero; Lixin Fan; Nicolas Sluis-Cremer; Yun-Xing Wang; Rieko Ishima
Journal:  Protein Sci       Date:  2022-05       Impact factor: 6.725

Review 2.  Retroviral RNase H: Structure, mechanism, and inhibition.

Authors:  Tatiana V Ilina; Teresa Brosenitsch; Nicolas Sluis-Cremer; Rieko Ishima
Journal:  Enzymes       Date:  2021-09-24

3.  An Alternative HIV-1 Non-Nucleoside Reverse Transcriptase Inhibition Mechanism: Targeting the p51 Subunit.

Authors:  Kwok-Fong Chan; Chinh Tran-To Su; Alexander Krah; Ser-Xian Phua; Joshua Yi Yeo; Wei-Li Ling; Peter J Bond; Samuel Ken-En Gan
Journal:  Molecules       Date:  2020-12-13       Impact factor: 4.411
  3 in total

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