Urology in the Time of Coronavirus: Reduced Access to Urgent and Emergent Urological Care during the Coronavirus Disease 2019 Outbreak in Italy.

PURPOSE: The coronavirus disease 2019 (COVID-19) pandemic has put a substantial burden on the Italian healthcare system, resulting in the restructuring of hospitals to care for COVID-19 patients. However, this has likely impacted access to care for patients experiencing other conditions. We aimed to quantify the impact of COVID-19 on access to care for patients with urgent/emergent urological conditions throughout Italy.
MATERIALS AND METHODS: A questionnaire was sent to 33 urological units in the AGILE consortium, asking clinicians to report on the number of urgent/emergent urological patients seen and/or undergoing surgery over a 3-week period during the peak of the COVID-19 outbreak and a reference week prior to the outbreak. ANOVA and linear regression models were used to quantify these changes.
RESULTS: Data from 27 urological centres in Italy showed a decrease from 956 patients/week seen just prior to the outbreak to 291 patients/week seen by the end of the study period. There was a difference in the number of patients with urgent/emergent urological disease seen within/during the different weeks (all p values < 0.05). A significant decrease in the number of patients presenting with haematuria, urinary retention, urinary tract infection, scrotal pain, renal colic, or trauma and urgent/emergent cases that required surgery was reported (all p values < 0.05).
CONCLUSION: In Italy, during the COVID-19 outbreak there has been a decrease in patients seeking help for urgent/emergent urological conditions. Restructuring of hospitals and clinics is mandatory to cope with the COVID-19 pandemic; however, the healthcare system should continue to provide adequate levels of care also to patients with other conditions.

Introduction

At the end of December 2019, the World Health Organization reported on an outbreak of cases of pneumonia of an unknown aetiology in Wuhan City, Hubei Province, China. By January 7, 2020 the number of cases had grown rapidly, and the virus had been isolated and named SARS-CoV-2 − colloquially known as the coronavirus − and the resulting disease was named coronavirus disease 2019 (COVID-19) [1]. By the end of January 2020, the virus had spread beyond China, to 19 other countries. As of January 31, 2020, there were two confirmed cases in Italy [2]. The outbreak in Italy started in the Lombardy region, but quickly spread to the whole country. By March 30, 2020, 97,689 confirmed cases and 10,779 deaths from the disease were reported in Italy [3].

In Italy, the exponential increase of cases led to an overtaxed health system, with a shortage of intensive care unit (ICU) beds and respiratory disease-related equipment. In response, hospitals and clinics were reorganized to respond to the growing outbreak. Internal medicine departments and ICUs shifted to focus on critically ill patients with COVID-19 [4]. This led to a disruption in care of patients presenting with other symptoms or emergent conditions, including urgent and emergent urological conditions.

Urological emergencies, including lower and upper urinary tract obstruction, obstructive pyelonephritis, gross haematuria with clot retention, and trauma, are not uncommon disorders. A delay to promptly recognize these emergencies may potentially lead to serious impairment such as renal failure, organ damage, or loss of sexual function [5, 6, 7].

According to World Bank Staff estimates, Italy has the second largest proportion of older adults in the world [8]. Older adults are more susceptible and more strongly affected by COVID-19, and they are also at greater risk of developing emergent urological conditions and relative complications.

The current multicentre study aimed to quantify changes in urgent and emergent urological care in Italy in the midst of the COVID-19 pandemic.

Materials and Methods

The AGILE group (Italian Group for Advanced Laparoscopic and Robotic Urologic Surgery) is a multicentre consortium consisting of 33 private and public urological departments and clinics across Italy. Data from 27 of these centres were included in this study. As of March 29, 2020 a standardized questionnaire (Fig. 1) was e-mailed to each of the departments and a quick response was requested. The questionnaire asked urologists to record and submit data with regard to patients presenting with urgent and emergent urological conditions (e.g., haematuria, urinary retention, urinary tract infection, scrotal pain, renal colic, and trauma) presenting at their respective institutions, including the number of emergent/urgent urological cases and the number of urgent/emergent cases that required surgery (e.g., endourological procedure, transurethral resection of bladder tumour, urethrotomy, and testicular detorsion). The included conditions and surgical procedures were considered representative markers to evaluate the usual urgent/emergent urological access. Accessibility to the emergency department operating facilities were reported for the weeks of February 24, 2020, March 2, 2020, March 9, 2020, and − as a reference − a standard week (e.g., a week without holidays, conference, or other impending duties for the medical staff) before February 22, 2020. Day clinicians reported data in real time, based on the scheduling in their hospital and in accordance with their respective ethics committees. Additionally, we coded the 27 centres by geographic area as (1) Lombardy − the epicentre of the outbreak (5 centres), (2) neighbouring regions of Lombardy (11 centres), and (3) other Italian regions (11 centres).

Fig. 1

E-mail questionnaire sent to the participating urological departments and centers. URS, ureteroscopy.

In the analyses, we summarized urgent/emergent urological cases and stratified these data by type of case that presented. We used ANOVA to examine the change in the number of cases presenting across the 4-week period. We additionally examined the linear trajectory of the number of urgent/emergent urological cases seen across Italy during this period. All statistical analyses were performed with Stata version 15 (StataCorp LLC, College Station, TX, USA).

Results

Across 27 urological centres located throughout Italy, 956 patients with urgent/emergent condition were seen in the reference week (prior to the COVID-19 outbreak), and this number decreased to 291 by the week of March 9, 2020.

Using ANOVA models, we observed a statistically significant difference between weeks in number of overall (p < 0.001) and surgical (p < 0.001) urgent and emergent urological patients seen (Table 1). There were significant decreases in patients presenting with haematuria (p < 0.001), urinary retention (p < 0.001), urinary tract infection (p < 0.001), scrotal pain (p < 0.001), and renal colic (p < 0.001). Additionally, there were decreases in patients who underwent endourological procedures (p = 0.002), transurethral resection of bladder tumour (p = 0.023), and testicular detorsion (p = 0.006). The decrease was not significant for the number of trauma or urethrotomy patients. Examining trends across the study period, we observed a significant linear decrease in both overall (B = −7.64, 95% CI −10.56 to −4.72, p < 0.001) and surgical (B = −1.66, 95% CI −2.51 to −0.81, p < 0.001) patients (Fig. 2, 3). In sensitivity analyses, we investigated whether the area of Italy impacted the observed trends in decreases in patients seen, but found no evidence of interaction by geographic area. Finally, we additionally investigated whether there were any differences between private and public or academic and non-academic institutions, but found no differences.

Table 1

Urgent and emergent urological patients, mean (standard deviation), ANOVA

	Reference week	COVID-19 week 1	COVID-19 week 2	COVID-19 week 3	p value
Emergent/urgent cases, total	35.4 (24.3)	20.3 (15.3)	17.8 (14.2)	10.8 (11.8)	<0.001
Emergent/urgent cases in surgery, total	8.7 (7.4)	4.4 (4.1)	3.6 (3.3)	3.4 (3.8)	<0.001
Cases by type
Haematuria	7.1 (5.7)	4.3 (3.5)	3.4 (2.8)	2.2 (2.3)	<0.001
Urinary retention	6.3 (5.7)	3.8 (3.6)	3.3 (3.2)	1.9 (2.4)	<0.001
Urinary tract infection	4.4 (3.5)	2.2 (2.3)	2.2 (2.4)	1.1 (1.7)	<0.001
Scrotal pain	3.7 (4.0)	2.1 (2.3)	1.6 (1.8)	0.9 (1.2)	<0.001
Renal colic	10.9 (6.9)	7.1 (6.2)	6.3 (5.4)	3.9 (4.8)	<0.001
Trauma	0.7 (0.8)	0.4 (0.8)	0.4 (0.6)	0.2 (0.6)	0.158
Emergency operating facilities
Endourology (URS, ureteral stenting)	5.0 (4.2)	2.9 (2.4)	2.2 (1.9)	2.2 (2.4)	0.002
Transurethral resection of bladder tumour	2.3 (3.0)	0.9 (1.9)	0.9 (1.6)	0.8 (1.3)	0.023
Urethrotomy	0.5 (0.8)	0.3 (0.6)	0.1 (0.5)	0.1 (0.4)	0.081
Testicular detorsion	0.8 (0.8)	0.4 (0.8)	0.2 (0.5)	0.2 (0.4)	0.006

Bold indicates statistical significance (p < 0.05). COVID-19, coronavirus disease 2019; URS, ureteroscopy.

Fig. 2

Trend of overall urgent and emergent urological cases.

Fig. 3

Trend with fit line of urgent and emergent surgical urological cases.

Discussion

This multicentre study summarizes the change in access to urgent urological care in Italy during the CO­VID-19 pandemic. We found, across a 4-week period including one reference week and 3 weeks during the peak of the COVID-19 pandemic, a progressive and significant decline of the overall accesses of urgent urological cases and of cases requiring urgent surgical management. We observed a significant decrease in nearly all types of cases, including haematuria, urinary retention, urinary tract infection, scrotal pain, renal colic, endourological procedure, transurethral resection of bladder tumour, and testicular detorsion. Moreover, in linear regression models, there was a significant, linear decrease in both number of surgical cases and overall cases. Interestingly, there was no difference in the number of cases seen across the 4-week period based on proximity to Lombardy, the epicentre of the outbreak.

This decreased number of accesses might be justified by the restrictions applied in Italy. The restriction in movements of the population except for necessity, work, and health circumstances (the so-called lockdown) in response to the growing pandemic might explain the reduction of patients who have hospital access for “not-essential” urgent urological consults. Also, staying home, resting, and avoiding exercise/outdoor activity may be a potential explanation for a decreased risk of certain conditions (e.g., urological trauma or testicular torsion) [9].

Overall, the COVID-19 pandemic has a significant impact on the management of the most important urological diseases; the normal urological activity has been significantly reduced. For example, all this has led to relevant consequences on the execution of diagnostic tests even for the most frequent urological neoplasm including radiological examination [10]; consequently, access to even non-invasive treatments [11] and the consequent quality of life of this type of patients were affected [12].

The COVID-19 outbreak in Italy, and indeed throughout the world, illustrates the need for a different type of care during pandemics. The reorganization of healthcare facilities to care for the overwhelming number of severe patients with easily transmittable disease resulted in reduced care and resources for patients with other urgent and emergent conditions. This is apparent in the observed decrease in patients with urgent and emergent urological conditions reported here. The hospitalization rate for COVID-19 patients is approximately 50%, while 16% of COVID-19 patients require ICU care [4]. This increased need to care for COVID-19 patients means there are fewer resources and personnel to care for patients with other urgent and emergent conditions. Indeed, healthcare workers are also at risk of becoming patients themselves. It has been estimated that 85% of healthcare workers will be exposed to the virus [13], and the International Council of Nurses estimated an infection rate of 9% in Italy [14].

This study was, as the situation warranted, conducted with careful haste. It provides a snapshot of the effect that the COVID-19 pandemic has on access to urgent and emergent care. However, although urological centres from across Italy were included and thus are likely representative of urological practice throughout the country, there could, of course, be aberrations, with only 27 centres reporting here. Additionally, although it is likely that these same patterns would be observed in any other specialty, this work is limited to urological data. Finally, although Italy's healthcare system is on par with those across Europe, some aspects of these findings may not be directly transferable to other European countries because of systematic and cultural differences.

Acknowledging these limitations, the current paper represents the first series so far exploring the impact of COVID-19 on the access to care for patients with urgent urological conditions. In particular, our findings strongly suggest that further protocols and facilities would be needed to provide care also for those patients who will inevitably develop other urgent conditions, irrespective of the COVID-19 pandemic. In this context, we identified future perspectives for the improvement of healthcare assistance: (1) create specific areas for the management and treatment of patients negative for COVID-19, either inside or outside of the existing structures; (2) improve education regarding infectious disease transmission for all healthcare providers; (3) meaningfully limit visitors' access to reduce the risk of contagion and, at the same time, to enhance patients' and employees' safety; and (4) delaying urological surgery should be considered whenever acceptable for the underlying disease, as reported by Stensland et al. [15], as a way of prioritizing the most urgent urological cases.

Conclusions

This multicentre study of urological units in Italy found a significant decrease in the number of patients treated for urgent and emergent urological conditions across a 3-week period during the COVID-19 pandemic. It is reasonable to assume that these patterns are being observed in other specialties as well. Italy has been substantially affected by the COVID-19 outbreak, with the second highest number of diseased individuals and the highest death rate of COVID-19 patients as of the end of March 2020 [3]. This outbreak has affected not only individuals with COVID-19, but also patients seeking care for other urgent and emergent conditions. Continued restructuring of the healthcare system is necessary to be able to continue providing a high level of care to all patients, even during times of pandemics.

Statement of Ethics

Proper consideration was given to any possible ethical issues. However, approval by an ethics commission was not applicable as this study is based on a survey.

Disclosure Statement

The authors have no conflicts of interest to declare.

Funding Sources

There are no funding sources.

Author Contributions

Conception and design: Porreca, Colicchia, Minervini. Acquisition of data: Colicchia, Porreca, Amenta, Corsaro, Zaramella, Zegna, Gallo, Schenone, Bozzini, Calori, Pastore, Al Salhi, Sciorio, Spirito, Varca, Marenghi, Greco, Altieri, Verze, Barba, Antonelli, Cerruto, Falabella, Di Bello, Leonardo, Tufano, Volpe, Umari, Parma, Nidini, Borghesi, Terrone, Sighinolfi, Finocchiaro, Falsaperla, Oderda, Ceruti, Rocco, Schiavina, Bianchi, Di Maida, Celia, Piroz­zi, Bove, Iacovelli, Cindolo, Ferrari, Gatti, Pirola, Annino, Pucci, Romagnoli. Analysis and interpretation of data: Colicchia, Porreca, Wennberg. Drafting of the manuscript: Porreca, Colicchia. Critical revision of the manuscript for important intellectual content: Porreca, Colicchia, D'Agostino, Pini, Bozzini, Verze, Cacciamani, Busetto, Rocco, Mari, Dalpiaz, Cafarelli, Artibani. Statistical analysis: Colicchia, Wennberg. Supervision: Minervini.